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ARTJ - ABC transporter arginine-binding protein 1
UniProt: P30860 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11628
Length: 243 (223)
Sequences: 10388
Seq/Len: 46.58

ARTJ
Paralog alert: 0.90 [within 20: 0.42] - ratio of genomes with paralogs
Cluster includes: ARGT ARTI ARTJ FLIY GLNH GLTI HISJ YHDW
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
130_G 168_I 3.825 1.00
26_G 81_Y 3.526 1.00
22_K 63_T 3.364 1.00
57_Q 226_A 3.171 1.00
102_T 225_A 2.553 1.00
153_Y 162_D 2.509 1.00
90_I 206_G 2.417 1.00
92_P 95_S 2.381 1.00
24_N 63_T 2.376 1.00
232_T 235_K 2.361 1.00
90_I 95_S 2.268 1.00
217_L 221_N 2.259 1.00
234_Q 238_D 2.208 1.00
24_N 65_T 2.187 1.00
75_S 81_Y 2.173 1.00
22_K 61_E 2.165 1.00
55_C 62_C 2.108 1.00
98_V 208_A 2.092 1.00
120_T 123_D 2.026 1.00
138_Q 152_S 2.011 1.00
225_A 229_A 2.004 1.00
53_A 56_K 2.002 1.00
155_S 158_N 1.986 1.00
38_G 44_V 1.981 1.00
138_Q 142_Q 1.965 1.00
209_V 217_L 1.945 1.00
128_R 151_V 1.929 1.00
209_V 220_L 1.913 1.00
53_A 232_T 1.886 1.00
77_K 97_Q 1.883 1.00
102_T 221_N 1.865 1.00
99_S 217_L 1.836 1.00
128_R 149_K 1.814 1.00
173_G 178_V 1.793 1.00
49_D 239_Q 1.773 1.00
210_R 213_N 1.764 1.00
57_Q 223_A 1.718 1.00
53_A 57_Q 1.71 1.00
53_A 227_I 1.682 1.00
101_T 221_N 1.678 1.00
85_I 207_I 1.606 1.00
57_Q 230_D 1.599 1.00
112_I 178_V 1.59 1.00
38_G 42_E 1.589 1.00
99_S 212_D 1.574 1.00
214_K 218_E 1.569 1.00
49_D 240_W 1.568 1.00
218_E 222_N 1.543 1.00
159_A 171_V 1.534 1.00
25_F 51_A 1.49 1.00
75_S 80_K 1.436 1.00
127_K 169_D 1.424 1.00
114_K 117_T 1.416 1.00
114_K 166_G 1.382 0.99
129_I 170_G 1.369 0.99
133_N 154_D 1.35 0.99
93_E 96_K 1.332 0.99
162_D 167_R 1.33 0.99
47_D 104_Y 1.329 0.99
25_F 83_A 1.319 0.99
163_L 168_I 1.317 0.99
219_K 222_N 1.316 0.99
52_K 64_F 1.31 0.99
154_D 158_N 1.308 0.99
115_K 189_G 1.307 0.99
175_T 179_N 1.302 0.99
79_R 210_R 1.299 0.99
58_M 223_A 1.297 0.99
101_T 220_L 1.292 0.99
36_S 44_V 1.284 0.99
116_D 189_G 1.282 0.99
139_K 143_D 1.279 0.99
99_S 214_K 1.277 0.99
111_V 170_G 1.272 0.99
73_I 98_V 1.258 0.99
222_N 226_A 1.254 0.99
54_L 223_A 1.251 0.99
219_K 223_A 1.222 0.98
232_T 236_I 1.222 0.98
72_L 84_V 1.222 0.98
46_F 236_I 1.219 0.98
106_E 204_G 1.216 0.98
132_E 135_T 1.215 0.98
130_G 153_Y 1.212 0.98
67_H 75_S 1.195 0.98
83_A 220_L 1.188 0.98
83_A 209_V 1.188 0.98
128_R 169_D 1.185 0.98
163_L 171_V 1.184 0.98
46_F 237_S 1.175 0.98
42_E 52_K 1.175 0.98
84_V 88_M 1.159 0.97
162_D 168_I 1.158 0.97
223_A 226_A 1.145 0.97
122_A 125_K 1.139 0.97
88_M 208_A 1.13 0.97
46_F 241_F 1.127 0.97
68_A 71_S 1.125 0.97
223_A 227_I 1.123 0.97
130_G 159_A 1.121 0.97
226_A 230_D 1.116 0.96
37_I 66_N 1.116 0.96
25_F 62_C 1.112 0.96
153_Y 159_A 1.112 0.96
140_Y 144_Q 1.102 0.96
228_K 233_Y 1.085 0.96
48_I 52_K 1.085 0.96
50_L 227_I 1.082 0.96
110_V 190_V 1.077 0.95
110_V 175_T 1.075 0.95
108_S 175_T 1.069 0.95
113_A 191_A 1.069 0.95
57_Q 227_I 1.065 0.95
49_D 52_K 1.06 0.95
52_K 56_K 1.056 0.95
142_Q 152_S 1.053 0.95
125_K 147_E 1.05 0.94
91_T 94_R 1.04 0.94
43_I 48_I 1.039 0.94
163_L 188_L 1.039 0.94
50_L 233_Y 1.033 0.94
99_S 211_P 1.031 0.94
51_A 85_I 1.028 0.94
51_A 64_F 1.022 0.93
34_F 105_Y 1.013 0.93
161_I 165_N 1.011 0.93
74_P 77_K 1.006 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2yjpA30.98351000.205Contact Map0.85
2y7iA20.93831000.208Contact Map0.804
1xt8A20.98351000.215Contact Map0.866
2ylnA10.97121000.219Contact Map0.821
3h7mA10.93421000.224Contact Map0.798
1lstA10.931000.226Contact Map0.833
3kzgA40.90951000.227Contact Map0.879
4kqpA10.92591000.228Contact Map0.8
3i6vA10.8931000.228Contact Map0.803
3k4uA60.91361000.23Contact Map0.839

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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