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ADEC - Adenine deaminase
UniProt: P31441 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11692
Length: 588 (570)
Sequences: 677
Seq/Len: 1.19

ADEC
Paralog alert: 0.10 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
34_I 77_A 4.26 1.00
52_I 82_A 3.792 1.00
494_Q 513_H 3.274 1.00
480_V 488_M 3.225 1.00
46_G 248_Q 3.217 1.00
298_D 302_R 3.032 1.00
77_A 345_L 3.008 1.00
494_Q 497_Q 2.968 1.00
409_R 582_T 2.96 1.00
484_S 487_E 2.931 1.00
439_F 485_A 2.794 1.00
82_A 345_L 2.734 1.00
102_T 105_T 2.653 1.00
525_D 529_S 2.642 1.00
409_R 422_S 2.573 1.00
23_V 60_A 2.556 1.00
347_S 353_T 2.552 1.00
167_T 170_Q 2.545 1.00
440_I 568_L 2.519 1.00
186_M 199_L 2.492 1.00
441_A 480_V 2.479 0.99
39_I 50_G 2.441 0.99
34_I 345_L 2.44 0.99
110_R 298_D 2.404 0.99
478_I 492_V 2.354 0.99
22_A 27_D 2.308 0.99
441_A 488_M 2.266 0.99
86_F 352_V 2.262 0.99
188_D 191_G 2.261 0.99
457_L 558_L 2.199 0.98
83_V 346_L 2.169 0.98
495_V 503_C 2.163 0.98
37_V 82_A 2.142 0.98
487_E 508_G 2.123 0.98
161_V 570_S 2.078 0.98
82_A 343_I 2.035 0.97
358_L 363_P 2.013 0.97
38_S 47_E 1.998 0.97
281_L 304_L 1.981 0.97
43_I 334_L 1.963 0.96
464_E 506_R 1.955 0.96
565_A 577_E 1.936 0.96
498_D 513_H 1.931 0.96
39_I 52_I 1.925 0.96
123_V 131_F 1.921 0.96
335_L 343_I 1.921 0.96
305_I 352_V 1.918 0.96
93_I 145_Q 1.905 0.95
468_A 491_A 1.895 0.95
412_D 423_H 1.848 0.94
489_A 493_N 1.841 0.94
36_N 76_D 1.831 0.94
395_A 486_E 1.826 0.94
277_P 325_R 1.816 0.94
41_D 44_N 1.808 0.93
37_V 77_A 1.808 0.93
345_L 358_L 1.757 0.92
25_R 222_E 1.755 0.92
159_C 574_F 1.743 0.92
139_E 179_Q 1.73 0.91
89_A 282_C 1.72 0.91
504_V 540_A 1.716 0.91
412_D 421_H 1.684 0.90
247_L 279_C 1.677 0.90
144_N 332_L 1.671 0.89
470_T 478_I 1.669 0.89
40_L 81_T 1.637 0.88
347_S 355_Q 1.618 0.87
498_D 503_C 1.617 0.87
136_R 139_E 1.615 0.87
525_D 533_Q 1.599 0.86
38_S 49_S 1.593 0.86
412_D 458_G 1.584 0.86
233_N 326_H 1.577 0.85
398_F 492_V 1.566 0.85
40_L 83_V 1.565 0.85
159_C 581_F 1.563 0.85
132_A 177_H 1.56 0.84
40_L 47_E 1.514 0.82
561_P 569_T 1.509 0.82
112_L 296_H 1.502 0.81
236_E 256_R 1.489 0.80
493_N 496_I 1.48 0.80
421_H 565_A 1.478 0.80
161_V 571_Q 1.468 0.79
343_I 358_L 1.464 0.79
40_L 316_Y 1.454 0.78
317_R 322_S 1.453 0.78
149_V 171_M 1.45 0.78
348_D 351_K 1.446 0.78
98_M 530_L 1.444 0.78
252_S 280_M 1.443 0.77
224_N 249_L 1.441 0.77
480_V 492_V 1.44 0.77
80_A 345_L 1.436 0.77
460_F 481_I 1.435 0.77
297_I 319_A 1.423 0.76
104_E 142_R 1.419 0.76
220_G 245_R 1.41 0.75
109_P 365_D 1.408 0.75
457_L 460_F 1.408 0.75
470_T 492_V 1.403 0.75
31_D 55_K 1.401 0.75
41_D 48_I 1.394 0.74
34_I 358_L 1.393 0.74
132_A 136_R 1.39 0.74
265_N 307_Q 1.387 0.73
518_I 524_T 1.383 0.73
400_L 456_L 1.381 0.73
455_G 470_T 1.373 0.72
106_A 527_A 1.362 0.72
265_N 303_R 1.361 0.71
293_H 535_D 1.36 0.71
190_P 579_F 1.359 0.71
80_A 355_Q 1.354 0.71
388_I 470_T 1.352 0.71
254_M 282_C 1.348 0.70
152_C 191_G 1.333 0.69
59_I 343_I 1.327 0.69
107_T 115_V 1.326 0.69
45_G 317_R 1.326 0.69
473_H 476_H 1.325 0.69
505_V 510_V 1.324 0.68
149_V 174_W 1.319 0.68
316_Y 320_S 1.315 0.68
45_G 313_H 1.307 0.67
161_V 451_A 1.307 0.67
425_S 458_G 1.303 0.67
517_P 524_T 1.301 0.66
443_L 452_P 1.295 0.66
91_L 283_T 1.295 0.66
75_I 358_L 1.29 0.65
160_D 570_S 1.285 0.65
395_A 489_A 1.284 0.65
301_I 344_V 1.283 0.65
278_Q 325_R 1.28 0.65
54_I 343_I 1.278 0.64
471_V 521_L 1.278 0.64
575_D 578_K 1.277 0.64
282_C 319_A 1.276 0.64
443_L 470_T 1.274 0.64
303_R 306_E 1.274 0.64
398_F 489_A 1.272 0.64
515_P 533_Q 1.269 0.64
60_A 228_T 1.263 0.63
473_H 560_L 1.259 0.63
120_H 187_M 1.256 0.62
438_S 483_R 1.256 0.62
490_L 494_Q 1.251 0.62
334_L 339_K 1.249 0.62
43_I 339_K 1.247 0.62
444_E 450_L 1.245 0.61
216_P 246_K 1.243 0.61
443_L 492_V 1.242 0.61
203_L 211_L 1.241 0.61
187_M 562_V 1.237 0.61
19_E 28_A 1.235 0.61
252_S 278_Q 1.228 0.60
398_F 441_A 1.227 0.60
138_A 179_Q 1.226 0.60
138_A 141_A 1.226 0.60
512_S 540_A 1.222 0.59
99_T 518_I 1.221 0.59
494_Q 498_D 1.22 0.59
37_V 345_L 1.219 0.59
148_Q 182_G 1.214 0.59
80_A 347_S 1.211 0.58
437_V 456_L 1.21 0.58
316_Y 352_V 1.21 0.58
41_D 46_G 1.21 0.58
261_A 418_L 1.205 0.58
30_A 53_V 1.204 0.58
112_L 553_I 1.204 0.58
271_I 318_V 1.202 0.57
476_H 560_L 1.202 0.57
120_H 476_H 1.196 0.57
33_I 51_P 1.193 0.57
120_H 473_H 1.187 0.56
574_F 581_F 1.183 0.56
515_P 537_L 1.179 0.55
464_E 507_N 1.178 0.55
128_E 174_W 1.177 0.55
422_S 582_T 1.177 0.55
440_I 481_I 1.169 0.54
122_I 130_G 1.159 0.53
529_S 533_Q 1.158 0.53
152_C 187_M 1.154 0.53
303_R 307_Q 1.152 0.53
494_Q 503_C 1.151 0.53
428_S 431_G 1.142 0.52
487_E 490_L 1.139 0.51
261_A 557_F 1.138 0.51
126_M 519_A 1.137 0.51
418_L 563_I 1.136 0.51
95_S 120_H 1.129 0.50
44_N 248_Q 1.129 0.50
122_I 134_F 1.128 0.50
22_A 195_G 1.126 0.50
124_N 473_H 1.123 0.50
297_I 300_L 1.118 0.49
408_Y 456_L 1.116 0.49
523_S 530_L 1.115 0.49
96_S 103_F 1.109 0.48
317_R 321_W 1.105 0.48
282_C 327_F 1.104 0.48
219_G 245_R 1.1 0.48
281_L 297_I 1.099 0.47
263_N 417_E 1.096 0.47
285_D 476_H 1.095 0.47
356_Q 363_P 1.091 0.47
188_D 196_Q 1.089 0.46
393_V 489_A 1.088 0.46
309_N 318_V 1.087 0.46
21_L 195_G 1.085 0.46
255_I 281_L 1.084 0.46
451_A 570_S 1.08 0.46
112_L 470_T 1.077 0.45
166_F 171_M 1.076 0.45
566_L 582_T 1.071 0.45
32_Y 54_I 1.07 0.45
155_A 475_S 1.069 0.45
133_W 137_C 1.069 0.45
506_R 511_Q 1.066 0.44
120_H 560_L 1.063 0.44
285_D 477_N 1.063 0.44
121_E 474_D 1.062 0.44
151_S 187_M 1.061 0.44
233_N 282_C 1.06 0.44
242_E 245_R 1.058 0.44
457_L 481_I 1.057 0.43
124_N 476_H 1.056 0.43
139_E 177_H 1.056 0.43
301_I 319_A 1.054 0.43
285_D 473_H 1.052 0.43
244_R 248_Q 1.05 0.43
45_G 312_L 1.048 0.43
495_V 499_G 1.046 0.42
124_N 154_P 1.043 0.42
161_V 574_F 1.038 0.42
187_M 476_H 1.035 0.41
504_V 544_C 1.035 0.41
254_M 327_F 1.035 0.41
186_M 191_G 1.034 0.41
144_N 359_V 1.033 0.41
121_E 476_H 1.033 0.41
52_I 335_L 1.031 0.41
95_S 476_H 1.031 0.41
285_D 560_L 1.031 0.41
236_E 258_G 1.03 0.41
93_I 470_T 1.028 0.41
91_L 296_H 1.026 0.40
115_V 143_Q 1.021 0.40
306_E 351_K 1.019 0.40
124_N 560_L 1.015 0.39
40_L 312_L 1.015 0.39
32_Y 75_I 1.014 0.39
259_S 327_F 1.013 0.39
148_Q 181_T 1.013 0.39
91_L 103_F 1.013 0.39
22_A 25_R 1.011 0.39
134_F 522_M 1.011 0.39
102_T 527_A 1.01 0.39
117_C 147_L 1.007 0.39
19_E 56_G 1.007 0.39
482_G 488_M 1.005 0.39
121_E 560_L 1.003 0.38
197_N 201_D 1.003 0.38
443_L 478_I 1.002 0.38
40_L 349_A 1 0.38
311_P 314_V 1 0.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3nqbA20.98641000.336Contact Map0.667
2icsA10.56971000.813Contact Map0.651
2ogjA60.62761000.818Contact Map0.609
3be7A80.56971000.821Contact Map0.654
3gnhA10.55611000.824Contact Map0.615
2vunA40.5851000.829Contact Map0.623
4b91A20.61391000.83Contact Map0.652
4gbdA20.62931000.831Contact Map0.65
1onwA20.58161000.831Contact Map0.689
4gy7A10.69561000.832Contact Map0.642

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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