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CBRA - Protein CbrA
UniProt: P31456 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11714
Length: 354 (313)
Sequences: 10774
Seq/Len: 34.42

CBRA
Paralog alert: 0.83 [within 20: 0.32] - ratio of genomes with paralogs
Cluster includes: CBRA FIXC UBIF UBIH VISC YDIS YGCN
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
29_I 118_Y 4.235 1.00
33_K 122_L 3.831 1.00
5_D 149_R 3.328 1.00
7_A 148_A 3.314 1.00
18_L 152_V 3.217 1.00
5_D 27_Q 3.196 1.00
312_W 316_R 3.17 1.00
7_A 135_V 3.084 1.00
153_G 161_V 2.708 1.00
125_K 164_H 2.6 1.00
14_A 289_A 2.542 1.00
125_K 136_I 2.484 1.00
134_H 147_T 2.472 1.00
7_A 31_L 2.418 1.00
4_F 29_I 2.351 1.00
121_S 140_D 2.35 1.00
123_C 135_V 2.321 1.00
31_L 146_I 2.317 1.00
68_D 109_S 2.314 1.00
127_W 134_H 2.296 1.00
14_A 271_I 2.272 1.00
105_L 109_S 2.252 1.00
136_I 145_H 2.237 1.00
154_A 271_I 2.118 1.00
17_A 290_L 2.116 1.00
20_R 110_L 2.086 1.00
31_L 137_F 2.071 1.00
264_G 309_T 2.044 1.00
6_V 26_M 2.02 1.00
27_Q 116_E 1.986 1.00
126_I 151_L 1.968 1.00
137_F 146_I 1.966 1.00
153_G 270_L 1.91 1.00
134_H 145_H 1.903 1.00
132_K 147_T 1.9 1.00
21_K 297_R 1.874 1.00
19_A 30_A 1.865 1.00
6_V 22_L 1.849 1.00
127_W 136_I 1.846 1.00
264_G 269_F 1.832 1.00
5_D 29_I 1.826 1.00
155_D 159_S 1.816 1.00
228_T 232_E 1.812 1.00
8_I 18_L 1.8 1.00
54_A 287_S 1.798 1.00
129_E 147_T 1.785 1.00
150_Y 308_N 1.781 1.00
111_I 115_V 1.775 1.00
118_Y 121_S 1.772 1.00
293_T 297_R 1.77 1.00
7_A 146_I 1.751 1.00
29_I 146_I 1.742 1.00
262_V 265_K 1.716 1.00
165_L 268_A 1.704 1.00
121_S 137_F 1.694 1.00
227_F 231_K 1.653 1.00
18_L 22_L 1.648 1.00
59_I 66_P 1.633 1.00
122_L 139_A 1.632 1.00
160_M 164_H 1.631 1.00
129_E 132_K 1.621 1.00
68_D 110_L 1.584 1.00
295_I 299_V 1.576 1.00
57_S 294_D 1.563 1.00
23_A 115_V 1.56 1.00
122_L 138_R 1.554 1.00
128_R 265_K 1.528 1.00
18_L 271_I 1.502 1.00
299_V 314_A 1.501 1.00
152_V 271_I 1.5 1.00
129_E 134_H 1.488 1.00
152_V 269_F 1.472 1.00
226_R 229_T 1.469 1.00
20_R 111_I 1.457 1.00
21_K 61_D 1.451 1.00
295_I 314_A 1.443 1.00
133_W 151_L 1.429 1.00
133_W 267_N 1.42 1.00
299_V 307_L 1.417 1.00
13_P 286_I 1.417 1.00
298_S 314_A 1.412 1.00
7_A 29_I 1.405 0.99
9_I 151_L 1.394 0.99
262_V 312_W 1.388 0.99
20_R 24_G 1.386 0.99
4_F 7_A 1.382 0.99
68_D 112_P 1.372 0.99
159_S 162_R 1.36 0.99
148_A 151_L 1.359 0.99
11_L 16_S 1.353 0.99
67_V 70_I 1.348 0.99
271_I 311_Y 1.339 0.99
264_G 305_E 1.336 0.99
8_I 28_V 1.327 0.99
67_V 71_A 1.318 0.99
17_A 21_K 1.316 0.99
68_D 71_A 1.311 0.99
157_A 277_F 1.31 0.99
269_F 296_L 1.306 0.99
20_R 61_D 1.298 0.99
135_V 151_L 1.294 0.99
66_P 70_I 1.289 0.99
123_C 126_I 1.264 0.99
276_G 292_S 1.262 0.99
128_R 267_N 1.261 0.99
26_M 301_L 1.26 0.99
4_F 116_E 1.249 0.99
9_I 123_C 1.246 0.98
123_C 161_V 1.242 0.98
124_R 139_A 1.242 0.98
8_I 19_A 1.239 0.98
110_L 113_A 1.235 0.98
31_L 118_Y 1.23 0.98
5_D 26_M 1.223 0.98
108_K 119_H 1.219 0.98
229_T 232_E 1.219 0.98
137_F 140_D 1.217 0.98
124_R 136_I 1.213 0.98
232_E 235_S 1.194 0.98
128_R 133_W 1.193 0.98
60_R 294_D 1.19 0.98
24_G 110_L 1.183 0.98
152_V 296_L 1.182 0.98
39_T 120_D 1.181 0.98
160_M 163_R 1.179 0.98
299_V 302_K 1.177 0.98
127_W 145_H 1.176 0.98
136_I 143_E 1.171 0.98
11_L 32_D 1.165 0.97
3_H 149_R 1.164 0.97
26_M 300_L 1.154 0.97
118_Y 146_I 1.142 0.97
17_A 61_D 1.142 0.97
299_V 310_A 1.141 0.97
55_Q 95_Y 1.128 0.97
45_P 48_G 1.127 0.97
265_K 268_A 1.124 0.97
295_I 298_S 1.122 0.97
102_A 105_L 1.12 0.96
28_V 115_V 1.113 0.96
294_D 298_S 1.095 0.96
263_C 312_W 1.09 0.96
54_A 290_L 1.088 0.96
150_Y 269_F 1.075 0.95
108_K 117_V 1.073 0.95
292_S 315_T 1.072 0.95
41_G 108_K 1.062 0.95
135_V 148_A 1.061 0.95
278_I 288_Y 1.059 0.95
31_L 121_S 1.058 0.95
138_R 143_E 1.054 0.95
21_K 293_T 1.048 0.94
9_I 161_V 1.048 0.94
309_T 313_R 1.045 0.94
161_V 268_A 1.044 0.94
30_A 117_V 1.038 0.94
229_T 233_K 1.031 0.94
264_G 312_W 1.03 0.94
270_L 274_A 1.013 0.93
118_Y 144_Q 1.01 0.93
22_L 26_M 1.01 0.93
310_A 313_R 1.009 0.93
99_N 102_A 1.005 0.93
198_I 201_C 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4n9xA10.97461000.294Contact Map0.721
2qa2A10.95481000.297Contact Map0.754
2qa1A10.95481000.306Contact Map0.795
3fmwA30.96051000.314Contact Map0.702
4k2xA20.95761000.315Contact Map0.811
4k5sA10.96051000.321Contact Map0.797
4k22A20.92371000.323Contact Map0.768
2x3nA10.96331000.324Contact Map0.775
3aljA10.93791000.333Contact Map0.785
4bjzA10.94921000.341Contact Map0.763

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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