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METI - D-methionine transport system permease protein MetI
UniProt: P31547 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11737
Length: 217 (204)
Sequences: 14745
Seq/Len: 72.28

METI
Paralog alert: 0.93 [within 20: 0.64] - ratio of genomes with paralogs
Cluster includes: ARTM ARTQ GLNP GLTJ GLTK HISM HISQ METI PHNE SSUC TAUC YECS YEHW
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
129_T 132_Q 3.127 1.00
26_F 97_T 3.114 1.00
92_A 164_G 3.016 1.00
131_M 135_R 2.939 1.00
185_N 188_V 2.877 1.00
14_W 18_A 2.853 1.00
124_R 133_I 2.594 1.00
151_T 207_G 2.469 1.00
123_S 133_I 2.294 1.00
120_I 133_I 2.255 1.00
205_F 209_R 2.188 1.00
34_V 101_A 2.166 1.00
66_I 71_L 2.13 1.00
35_G 108_V 2.053 1.00
51_K 55_T 2.02 1.00
37_L 56_V 1.987 1.00
209_R 212_R 1.98 1.00
34_V 105_A 1.908 1.00
18_A 22_V 1.9 1.00
123_S 137_V 1.898 1.00
119_L 141_E 1.896 1.00
176_G 193_L 1.892 1.00
20_T 158_V 1.875 1.00
39_Y 112_L 1.87 1.00
30_I 101_A 1.835 1.00
132_Q 136_K 1.834 1.00
120_I 124_R 1.76 1.00
51_K 54_R 1.75 1.00
27_G 100_A 1.687 1.00
10_V 14_W 1.641 1.00
60_V 105_A 1.64 1.00
22_V 93_I 1.635 1.00
13_V 199_L 1.621 1.00
174_Q 178_Q 1.607 1.00
18_A 89_L 1.606 1.00
209_R 213_A 1.563 1.00
111_A 146_L 1.527 1.00
15_E 18_A 1.52 1.00
197_V 201_Y 1.519 1.00
205_F 208_D 1.509 1.00
130_P 133_I 1.492 1.00
35_G 39_Y 1.485 1.00
123_S 128_A 1.475 1.00
104_I 153_T 1.474 1.00
201_Y 205_F 1.468 1.00
31_G 104_I 1.453 1.00
24_G 154_L 1.429 1.00
38_L 57_S 1.427 1.00
111_A 145_G 1.42 1.00
30_I 97_T 1.418 1.00
12_G 175_I 1.393 0.99
29_V 33_P 1.371 0.99
11_R 14_W 1.365 0.99
75_M 94_V 1.364 0.99
53_Y 113_L 1.364 0.99
26_F 93_I 1.363 0.99
108_V 146_L 1.344 0.99
90_Q 94_V 1.337 0.99
39_Y 113_L 1.309 0.99
16_T 161_S 1.305 0.99
132_Q 135_R 1.3 0.99
130_P 134_V 1.283 0.99
128_A 132_Q 1.279 0.99
162_A 196_L 1.274 0.99
129_T 133_I 1.27 0.99
19_M 89_L 1.265 0.99
114_E 145_G 1.263 0.99
175_I 178_Q 1.262 0.99
89_L 93_I 1.256 0.99
206_A 210_I 1.244 0.98
42_R 54_R 1.233 0.98
20_T 161_S 1.225 0.98
19_M 164_G 1.225 0.98
206_A 209_R 1.219 0.98
31_G 105_A 1.219 0.98
120_I 138_L 1.212 0.98
112_L 138_L 1.209 0.98
124_R 130_P 1.191 0.98
158_V 203_I 1.177 0.98
66_I 99_G 1.175 0.98
40_V 130_P 1.156 0.97
30_I 33_P 1.153 0.97
28_F 150_A 1.148 0.97
35_G 112_L 1.129 0.97
32_L 108_V 1.119 0.96
117_T 121_E 1.114 0.96
33_P 37_L 1.11 0.96
11_R 15_E 1.103 0.96
53_Y 57_S 1.099 0.96
71_L 99_G 1.089 0.96
23_S 157_L 1.079 0.95
109_E 113_L 1.052 0.95
23_S 96_L 1.044 0.94
101_A 105_A 1.036 0.94
75_M 95_P 1.034 0.94
42_R 51_K 1.019 0.93
42_R 53_Y 1.016 0.93
24_G 157_L 1.015 0.93
122_A 126_M 1.008 0.93
202_L 206_A 1.008 0.93
23_S 97_T 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tuiA40.990899.90.442Contact Map0.8
3rlfF10.963199.90.476Contact Map0.676
2onkC40.944799.90.497Contact Map0.641
3d31C20.944799.90.499Contact Map0.586
3rlfG10.958599.80.553Contact Map0.571
2kv5A10.14754.30.951Contact Map0.425
4k0jA60.82033.10.955Contact Map0.273
3w9iA60.84332.50.957Contact Map0.406
4a2nB10.31342.30.957Contact Map0.399
4dx5A30.85712.10.958Contact Map0.39

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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