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THIQ - Thiamine import ATP-binding protein ThiQ
UniProt: P31548 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11572
Length: 232 (231)
Sequences: 71165
Seq/Len: 308.07

THIQ
Paralog alert: 0.93 [within 20: 0.83] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
29_A 197_A 3.174 1.00
3_K 21_T 3.124 1.00
55_S 62_D 2.952 1.00
26_E 199_R 2.937 1.00
5_T 55_S 2.907 1.00
122_L 125_R 2.899 1.00
115_R 120_D 2.888 1.00
6_D 17_R 2.873 1.00
72_P 149_P 2.687 1.00
13_H 16_M 2.667 1.00
23_E 26_E 2.605 1.00
3_K 57_T 2.586 1.00
16_M 207_R 2.546 1.00
28_V 201_V 2.529 1.00
199_R 211_Q 2.51 1.00
8_T 17_R 2.279 1.00
212_G 216_E 2.202 1.00
4_L 7_I 2.174 1.00
8_T 13_H 2.167 1.00
109_K 147_E 2.151 1.00
10_L 13_H 2.11 1.00
8_T 53_S 2.096 1.00
5_T 57_T 2.079 1.00
9_W 44_L 1.998 1.00
111_H 123_M 1.988 1.00
88_V 130_L 1.96 1.00
213_M 216_E 1.952 1.00
114_A 123_M 1.95 1.00
59_D 149_P 1.94 1.00
147_E 181_M 1.868 1.00
89_A 111_H 1.78 1.00
89_A 124_A 1.775 1.00
26_E 198_T 1.769 1.00
116_Q 174_T 1.742 1.00
201_V 211_Q 1.741 1.00
89_A 123_M 1.734 1.00
6_D 19_S 1.709 1.00
24_R 149_P 1.697 1.00
174_T 178_Q 1.696 1.00
201_V 208_I 1.687 1.00
11_Y 14_L 1.683 1.00
89_A 93_G 1.68 1.00
107_Q 111_H 1.637 1.00
112_A 116_Q 1.615 1.00
89_A 110_M 1.614 1.00
10_L 52_A 1.53 1.00
42_L 152_L 1.511 1.00
9_W 52_A 1.507 1.00
89_A 107_Q 1.506 1.00
9_W 49_L 1.458 1.00
42_L 186_V 1.455 1.00
20_L 201_V 1.453 1.00
22_V 28_V 1.409 1.00
57_T 62_D 1.399 0.99
109_K 112_A 1.396 0.99
125_R 129_E 1.384 0.99
78_Q 132_G 1.368 0.99
111_H 115_R 1.361 0.99
44_L 51_P 1.355 0.99
4_L 45_I 1.35 0.99
120_D 123_M 1.34 0.99
5_T 21_T 1.317 0.99
176_C 198_T 1.303 0.99
15_P 44_L 1.302 0.99
108_G 112_A 1.299 0.99
111_H 120_D 1.292 0.99
102_L 105_V 1.271 0.99
7_I 51_P 1.27 0.99
8_T 16_M 1.264 0.99
87_T 90_Q 1.228 0.98
93_G 110_M 1.211 0.98
4_L 20_L 1.198 0.98
153_L 172_V 1.197 0.98
92_I 145_V 1.196 0.98
93_G 107_Q 1.194 0.98
122_L 134_Q 1.191 0.98
9_W 40_T 1.187 0.98
116_Q 179_Q 1.185 0.98
91_N 142_R 1.176 0.98
88_V 138_V 1.173 0.98
116_Q 178_Q 1.161 0.97
59_D 72_P 1.161 0.97
45_I 184_L 1.158 0.97
41_L 203_V 1.156 0.97
23_E 199_R 1.15 0.97
5_T 19_S 1.146 0.97
93_G 106_Q 1.145 0.97
119_I 122_L 1.143 0.97
114_A 119_I 1.143 0.97
109_K 113_I 1.14 0.97
176_C 183_L 1.135 0.97
4_L 41_L 1.13 0.97
47_G 50_T 1.128 0.97
28_V 211_Q 1.128 0.97
43_N 49_L 1.118 0.96
204_A 209_A 1.113 0.96
187_S 193_A 1.112 0.96
209_A 223_S 1.109 0.96
46_A 75_M 1.095 0.96
10_L 14_L 1.095 0.96
74_S 148_Q 1.091 0.96
173_S 195_R 1.089 0.96
171_L 174_T 1.088 0.96
212_G 217_L 1.086 0.96
28_V 199_R 1.085 0.96
112_A 115_R 1.077 0.95
92_I 114_A 1.074 0.95
44_L 56_L 1.049 0.94
27_Q 185_M 1.042 0.94
76_L 140_L 1.041 0.94
117_M 141_A 1.04 0.94
27_Q 183_L 1.037 0.94
118_G 167_E 1.035 0.94
30_I 41_L 1.025 0.93
27_Q 196_I 1.023 0.93
27_Q 176_C 1.021 0.93
149_P 181_M 1.017 0.93
165_R 189_S 1.014 0.93
175_S 181_M 1.013 0.93
90_Q 93_G 1.013 0.93
1_M 59_D 1.012 0.93
165_R 192_D 1.004 0.93
24_R 59_D 1.001 0.92
169_L 192_D 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2it1A21100-0.096Contact Map0.865
1v43A11100-0.095Contact Map0.809
2yyzA11100-0.094Contact Map0.814
1g29121100-0.092Contact Map0.887
1oxxK11100-0.09Contact Map0.78
3rlfA21100-0.089Contact Map0.833
1z47A21100-0.086Contact Map0.831
3fvqA21100-0.085Contact Map0.761
3tuiC41100-0.085Contact Map0.863
3d31A20.9871100-0.081Contact Map0.782

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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