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CAID - Carnitinyl-CoA dehydratase
UniProt: P31551 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11557
Length: 261 (254)
Sequences: 13353
Seq/Len: 52.57

CAID
Paralog alert: 0.70 [within 20: 0.25] - ratio of genomes with paralogs
Cluster includes: CAID MENB PAAF PAAG SCPB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
178_R 188_N 3.274 1.00
126_S 164_R 3.115 1.00
123_D 181_S 3.107 1.00
188_N 191_E 3.01 1.00
121_C 176_V 2.954 1.00
99_A 116_A 2.619 1.00
15_E 190_R 2.594 1.00
42_R 94_D 2.559 1.00
124_N 182_Q 2.471 1.00
163_R 195_Q 2.427 1.00
166_G 169_E 2.331 1.00
6_H 19_D 2.3 1.00
157_E 163_R 2.226 1.00
133_K 199_S 2.192 1.00
169_E 172_R 2.159 1.00
218_P 221_E 2.125 1.00
39_L 89_E 2.111 1.00
248_L 252_E 2.05 1.00
154_I 173_W 2.028 1.00
123_D 168_E 2.014 1.00
184_E 187_D 1.978 1.00
100_A 189_A 1.977 1.00
106_F 128_A 1.963 1.00
120_V 180_V 1.957 1.00
159_V 207_L 1.954 1.00
100_A 186_M 1.905 1.00
29_K 33_E 1.806 1.00
19_D 55_A 1.785 1.00
14_L 41_F 1.782 1.00
12_S 48_R 1.77 1.00
15_E 53_T 1.756 1.00
245_E 254_R 1.752 1.00
157_E 177_N 1.747 1.00
169_E 173_W 1.743 1.00
50_A 93_L 1.741 1.00
241_E 261_R 1.733 1.00
17_T 55_A 1.733 1.00
53_T 102_N 1.727 1.00
9_R 14_L 1.717 1.00
168_E 172_R 1.713 1.00
123_D 182_Q 1.668 1.00
163_R 169_E 1.657 1.00
121_C 127_F 1.622 1.00
120_V 192_L 1.622 1.00
9_R 44_D 1.621 1.00
17_T 53_T 1.607 1.00
156_N 212_R 1.607 1.00
113_A 119_I 1.607 1.00
41_F 50_A 1.599 1.00
156_N 211_Y 1.599 1.00
157_E 178_R 1.591 1.00
152_P 156_N 1.586 1.00
7_L 14_L 1.575 1.00
35_G 89_E 1.571 1.00
156_N 160_M 1.527 1.00
119_I 153_A 1.522 1.00
184_E 188_N 1.486 1.00
190_R 194_Q 1.478 1.00
40_N 44_D 1.478 1.00
119_I 149_I 1.472 1.00
11_G 194_Q 1.472 1.00
132_A 162_G 1.47 1.00
180_V 188_N 1.447 1.00
241_E 259_K 1.442 1.00
90_I 97_V 1.44 1.00
14_L 47_L 1.439 1.00
42_R 89_E 1.422 1.00
117_D 208_K 1.421 1.00
18_L 30_T 1.414 1.00
49_V 193_A 1.414 1.00
10_N 194_Q 1.413 1.00
27_D 30_T 1.406 0.99
7_L 41_F 1.386 0.99
171_L 179_V 1.373 0.99
101_V 105_A 1.371 0.99
16_I 37_V 1.367 0.99
102_N 122_A 1.365 0.99
122_A 182_Q 1.358 0.99
10_N 190_R 1.351 0.99
38_F 93_L 1.343 0.99
102_N 124_N 1.336 0.99
110_F 129_L 1.334 0.99
209_E 213_T 1.332 0.99
158_M 165_M 1.329 0.99
185_L 189_A 1.323 0.99
51_I 189_A 1.309 0.99
186_M 189_A 1.298 0.99
23_A 67_K 1.289 0.99
28_A 68_A 1.277 0.99
15_E 186_M 1.259 0.99
91_F 145_R 1.256 0.99
154_I 157_E 1.248 0.99
122_A 185_L 1.242 0.98
186_M 190_R 1.232 0.98
50_A 95_K 1.23 0.98
35_G 39_L 1.201 0.98
33_E 37_V 1.2 0.98
128_A 164_R 1.199 0.98
154_I 169_E 1.179 0.98
153_A 177_N 1.149 0.97
53_T 186_M 1.138 0.97
58_K 102_N 1.135 0.97
167_A 179_V 1.125 0.97
151_P 154_I 1.124 0.97
101_V 113_A 1.114 0.96
217_M 221_E 1.11 0.96
88_T 92_N 1.109 0.96
18_L 61_S 1.109 0.96
104_Y 126_S 1.104 0.96
61_S 109_G 1.103 0.96
118_F 192_L 1.101 0.96
199_S 204_I 1.095 0.96
146_L 150_L 1.085 0.96
67_K 251_A 1.084 0.96
10_N 15_E 1.082 0.96
20_R 65_D 1.068 0.95
165_M 173_W 1.068 0.95
150_L 154_I 1.061 0.95
206_A 236_S 1.06 0.95
193_A 197_V 1.058 0.95
243_A 247_P 1.05 0.94
143_V 226_I 1.046 0.94
101_V 119_I 1.045 0.94
36_E 40_N 1.028 0.94
20_R 23_A 1.025 0.93
6_H 55_A 1.021 0.93
45_P 95_K 1.017 0.93
101_V 127_F 1.016 0.93
32_F 83_G 1.014 0.93
189_A 193_A 1.013 0.93
59_F 104_Y 1.012 0.93
15_E 51_I 1.01 0.93
8_T 17_T 1.008 0.93
92_N 220_E 1.008 0.93
88_T 220_E 1.005 0.93
221_E 224_R 1.002 0.92
168_E 171_L 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2ej5A20.9771000.014Contact Map0.703
3qxzA30.9771000.014Contact Map0.74
3kqfA60.98471000.016Contact Map0.827
4jfcA10.97321000.017Contact Map0.702
3sllA60.98081000.017Contact Map0.848
4fzwC20.98081000.017Contact Map0.662
4lk5A30.98081000.017Contact Map0.703
1nzyA20.98081000.018Contact Map0.739
4jwvA20.97321000.018Contact Map0.65
3swxA30.98081000.021Contact Map0.763

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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