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CAIC - Probable crotonobetaine/carnitine-CoA ligase
UniProt: P31552 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11558
Length: 517 (508)
Sequences: 30942
Seq/Len: 60.91

CAIC
Paralog alert: 0.83 [within 20: 0.45] - ratio of genomes with paralogs
Cluster includes: ACSA CAIC ENTE FADK LCFA MENE PRPE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
175_T 192_V 3.916 1.00
369_I 406_G 3.686 1.00
107_N 180_F 3.483 1.00
59_I 87_A 3.267 1.00
350_E 372_K 3.129 1.00
48_N 84_K 3.022 1.00
386_N 389_A 2.917 1.00
63_D 111_C 2.896 1.00
66_A 110_A 2.889 1.00
407_Y 415_Y 2.816 1.00
443_H 483_F 2.774 1.00
194_T 381_K 2.75 1.00
355_D 359_R 2.748 1.00
425_K 430_N 2.641 1.00
44_N 84_K 2.599 1.00
109_Q 385_L 2.551 1.00
448_D 505_R 2.508 1.00
352_E 360_P 2.472 1.00
64_K 90_V 2.467 1.00
24_T 37_R 2.445 1.00
368_E 401_H 2.417 1.00
256_G 260_K 2.374 1.00
78_C 114_V 2.321 1.00
354_R 370_C 2.285 1.00
441_A 449_I 2.267 1.00
440_I 465_A 2.237 1.00
20_Y 23_K 2.204 1.00
366_I 405_T 2.204 1.00
389_A 392_K 2.167 1.00
107_N 386_N 2.15 1.00
387_P 391_A 2.14 1.00
46_E 77_F 2.112 1.00
82_L 87_A 2.104 1.00
27_I 242_T 2.099 1.00
464_K 498_E 2.092 1.00
216_V 242_T 2.085 1.00
50_T 77_F 2.081 1.00
370_C 401_H 2.066 1.00
53_L 57_L 2.065 1.00
44_N 48_N 2.046 1.00
373_G 376_G 2.038 1.00
103_W 187_R 2.008 1.00
61_K 174_D 2.004 1.00
41_L 45_Q 1.967 1.00
14_D 44_N 1.954 1.00
215_D 264_T 1.923 1.00
409_D 415_Y 1.922 1.00
353_I 406_G 1.917 1.00
408_R 414_F 1.909 1.00
388_Q 392_K 1.894 1.00
426_R 431_V 1.887 1.00
341_S 415_Y 1.868 1.00
352_E 370_C 1.863 1.00
442_A 487_N 1.861 1.00
22_H 41_L 1.853 1.00
512_I 515_N 1.847 1.00
55_Y 85_I 1.842 1.00
39_S 42_E 1.837 1.00
476_S 479_E 1.806 1.00
102_A 106_Q 1.795 1.00
111_C 135_R 1.792 1.00
50_T 81_G 1.78 1.00
60_R 63_D 1.761 1.00
409_D 413_F 1.754 1.00
244_V 263_A 1.745 1.00
16_L 20_Y 1.745 1.00
38_Y 77_F 1.735 1.00
83_A 176_A 1.726 1.00
215_D 291_R 1.724 1.00
47_I 84_K 1.72 1.00
66_A 92_I 1.715 1.00
65_V 82_L 1.708 1.00
466_F 516_L 1.707 1.00
81_G 85_I 1.702 1.00
445_K 479_E 1.701 1.00
171_S 174_D 1.698 1.00
28_C 73_P 1.692 1.00
435_E 492_K 1.686 1.00
422_N 513_R 1.665 1.00
451_V 465_A 1.664 1.00
70_D 116_S 1.658 1.00
468_V 503_L 1.647 1.00
301_E 305_D 1.645 1.00
108_S 180_F 1.643 1.00
48_N 52_N 1.633 1.00
59_I 65_V 1.628 1.00
406_G 416_F 1.625 1.00
305_D 309_E 1.622 1.00
65_V 87_A 1.613 1.00
441_A 448_D 1.605 1.00
366_I 417_V 1.603 1.00
194_T 197_N 1.602 1.00
76_I 233_A 1.598 1.00
407_Y 417_V 1.597 1.00
437_E 451_V 1.579 1.00
62_G 174_D 1.576 1.00
25_A 43_L 1.565 1.00
262_R 289_R 1.564 1.00
24_T 39_S 1.56 1.00
363_A 408_R 1.559 1.00
212_R 215_D 1.555 1.00
175_T 381_K 1.55 1.00
15_D 19_V 1.546 1.00
23_K 214_D 1.545 1.00
42_E 45_Q 1.544 1.00
452_V 466_F 1.542 1.00
268_C 273_I 1.541 1.00
321_M 400_L 1.516 1.00
66_A 105_L 1.514 1.00
258_V 289_R 1.514 1.00
53_L 156_L 1.514 1.00
27_I 37_R 1.504 1.00
64_K 384_F 1.502 1.00
45_Q 49_R 1.5 1.00
192_V 382_E 1.499 1.00
178_I 384_F 1.494 1.00
197_N 325_I 1.491 1.00
351_A 371_I 1.488 1.00
27_I 261_Y 1.48 1.00
47_I 81_G 1.465 1.00
236_A 241_A 1.461 1.00
481_F 497_L 1.461 1.00
180_F 190_G 1.449 1.00
173_D 196_Y 1.447 1.00
355_D 361_L 1.446 1.00
369_I 416_F 1.446 1.00
393_V 400_L 1.442 1.00
107_N 385_L 1.436 1.00
37_R 261_Y 1.435 1.00
21_G 41_L 1.432 1.00
253_A 256_G 1.431 1.00
92_I 101_S 1.428 1.00
424_I 433_C 1.425 1.00
197_N 379_I 1.424 1.00
218_L 263_A 1.42 1.00
215_D 265_V 1.418 1.00
483_F 487_N 1.414 1.00
24_T 27_I 1.409 1.00
485_E 493_V 1.397 0.99
38_Y 73_P 1.39 0.99
59_I 112_L 1.387 0.99
362_P 365_E 1.384 0.99
43_L 80_F 1.379 0.99
62_G 381_K 1.378 0.99
506_N 512_I 1.376 0.99
50_T 114_V 1.362 0.99
445_K 473_E 1.36 0.99
447_Q 470_N 1.343 0.99
88_I 175_T 1.341 0.99
46_E 49_R 1.337 0.99
24_T 242_T 1.337 0.99
372_K 399_W 1.329 0.99
395_E 401_H 1.324 0.99
405_T 420_R 1.318 0.99
482_R 486_Q 1.318 0.99
478_E 482_R 1.317 0.99
259_Q 285_D 1.301 0.99
105_L 110_A 1.299 0.99
371_I 402_T 1.297 0.99
380_F 394_L 1.29 0.99
454_I 464_K 1.285 0.99
216_V 263_A 1.283 0.99
366_I 407_Y 1.282 0.99
181_T 191_V 1.275 0.99
300_S 303_E 1.274 0.99
250_S 253_A 1.272 0.99
59_I 63_D 1.271 0.99
193_I 197_N 1.264 0.99
480_F 497_L 1.262 0.99
353_I 361_L 1.258 0.99
67_L 78_C 1.254 0.99
106_Q 187_R 1.252 0.99
80_F 237_F 1.252 0.99
434_V 438_N 1.246 0.98
469_L 499_I 1.246 0.98
456_D 462_A 1.241 0.98
368_E 420_R 1.227 0.98
192_V 384_F 1.223 0.98
90_V 108_S 1.222 0.98
257_Q 261_Y 1.222 0.98
439_I 484_C 1.21 0.98
485_E 490_K 1.209 0.98
369_I 414_F 1.208 0.98
64_K 88_I 1.205 0.98
222_P 225_H 1.203 0.98
454_I 496_Y 1.2 0.98
103_W 107_N 1.198 0.98
246_V 257_Q 1.197 0.98
467_V 499_I 1.195 0.98
356_D 420_R 1.188 0.98
361_L 365_E 1.183 0.98
439_I 487_N 1.176 0.98
100_E 492_K 1.175 0.98
484_C 493_V 1.175 0.98
178_I 190_G 1.173 0.98
422_N 434_V 1.172 0.98
43_L 77_F 1.171 0.98
455_K 461_E 1.171 0.98
107_N 187_R 1.171 0.98
17_A 44_N 1.168 0.97
338_R 411_E 1.166 0.97
424_I 463_I 1.16 0.97
467_V 497_L 1.16 0.97
483_F 486_Q 1.159 0.97
103_W 180_F 1.156 0.97
16_L 19_V 1.154 0.97
152_S 155_Q 1.153 0.97
38_Y 46_E 1.153 0.97
64_K 178_I 1.146 0.97
440_I 449_I 1.144 0.97
345_V 351_A 1.142 0.97
423_M 432_S 1.141 0.97
503_L 511_I 1.14 0.97
278_V 306_A 1.135 0.97
44_N 47_I 1.13 0.97
216_V 244_V 1.129 0.97
73_P 77_F 1.127 0.97
469_L 475_L 1.126 0.97
405_T 418_D 1.125 0.97
464_K 496_Y 1.123 0.97
349_Y 378_T 1.12 0.96
328_I 371_I 1.116 0.96
46_E 74_E 1.116 0.96
477_E 497_L 1.112 0.96
352_E 399_W 1.111 0.96
306_A 310_R 1.102 0.96
500_R 503_L 1.097 0.96
38_Y 43_L 1.093 0.96
351_A 414_F 1.091 0.96
50_T 78_C 1.089 0.96
172_T 196_Y 1.089 0.96
489_A 492_K 1.087 0.96
266_T 290_L 1.086 0.96
43_L 47_I 1.085 0.96
179_L 322_T 1.081 0.95
443_H 480_F 1.077 0.95
351_A 369_I 1.076 0.95
36_N 46_E 1.076 0.95
477_E 499_I 1.074 0.95
13_W 17_A 1.074 0.95
53_L 56_T 1.071 0.95
466_F 500_R 1.071 0.95
388_Q 391_A 1.065 0.95
373_G 379_I 1.063 0.95
196_Y 377_K 1.063 0.95
68_H 101_S 1.062 0.95
51_A 84_K 1.055 0.95
443_H 479_E 1.054 0.95
182_S 508_S 1.051 0.94
176_A 195_H 1.05 0.94
427_G 459_R 1.047 0.94
236_A 243_F 1.045 0.94
442_A 483_F 1.044 0.94
462_A 495_S 1.043 0.94
324_T 400_L 1.041 0.94
217_Y 236_A 1.04 0.94
63_D 87_A 1.037 0.94
355_D 365_E 1.034 0.94
25_A 40_Y 1.033 0.94
77_F 81_G 1.029 0.94
54_F 114_V 1.026 0.94
307_F 311_F 1.026 0.94
64_K 109_Q 1.025 0.93
481_F 485_E 1.025 0.93
192_V 381_K 1.024 0.93
216_V 264_T 1.023 0.93
353_I 414_F 1.023 0.93
249_Y 272_M 1.023 0.93
465_A 497_L 1.022 0.93
14_D 84_K 1.022 0.93
429_E 491_F 1.02 0.93
54_F 82_L 1.014 0.93
244_V 257_Q 1.007 0.93
175_T 194_T 1.006 0.93
329_I 351_A 1.003 0.93
344_R 413_F 1.002 0.92
191_V 380_F 1 0.92
69_L 72_C 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tsyA10.98261000.112Contact Map0.782
3etcA20.98841000.117Contact Map0.843
1mdbA10.96521000.117Contact Map0.779
3o83A20.97291000.122Contact Map0.761
3ni2A10.97491000.122Contact Map0.806
3g7sA20.97491000.123Contact Map0.792
3r44A10.96131000.128Contact Map0.813
2d1sA10.98261000.132Contact Map0.719
2v7bA20.97681000.133Contact Map0.797
1pg4A20.99611000.135Contact Map0.779

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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