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CAIT - L-carnitine/gamma-butyrobetaine antiporter
UniProt: P31553 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11561
Length: 504 (496)
Sequences: 1518
Seq/Len: 3.06

CAIT
Paralog alert: 0.56 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: BETT CAIT YEAV
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
197_L 434_T 3.382 1.00
54_A 484_F 3.274 1.00
78_R 83_P 3.191 1.00
272_W 407_T 2.975 1.00
175_L 192_V 2.807 1.00
82_E 340_R 2.796 1.00
272_W 276_V 2.788 1.00
233_A 461_I 2.544 1.00
27_W 31_R 2.543 1.00
86_F 252_Q 2.477 1.00
47_V 481_C 2.238 1.00
369_N 401_L 2.207 1.00
127_S 130_A 2.192 1.00
112_I 115_Y 2.184 1.00
423_V 456_V 2.159 1.00
216_T 231_L 2.156 1.00
17_P 194_N 2.143 1.00
421_T 425_A 2.1 1.00
374_I 380_N 2.056 1.00
230_Q 234_I 2.055 1.00
274_F 365_V 2.049 1.00
249_C 257_I 2.027 1.00
19_L 451_G 2.005 1.00
245_I 249_C 1.99 1.00
32_D 35_A 1.976 1.00
65_G 491_T 1.97 1.00
186_G 189_G 1.949 1.00
90_S 260_D 1.933 1.00
286_F 364_T 1.932 1.00
240_I 457_G 1.905 0.99
70_V 349_F 1.891 0.99
61_V 488_I 1.886 0.99
274_F 283_M 1.88 0.99
273_V 401_L 1.864 0.99
67_F 71_F 1.859 0.99
326_I 476_I 1.849 0.99
70_V 348_C 1.814 0.99
72_G 75_A 1.809 0.99
172_S 190_T 1.793 0.99
58_Y 62_M 1.779 0.99
179_V 188_F 1.778 0.99
270_L 365_V 1.775 0.99
139_L 360_W 1.768 0.99
113_Y 381_I 1.76 0.99
28_L 35_A 1.758 0.99
285_Y 368_S 1.756 0.99
244_A 248_A 1.75 0.99
58_Y 484_F 1.745 0.99
240_I 243_N 1.737 0.99
423_V 427_S 1.732 0.99
427_S 453_S 1.729 0.99
485_F 489_M 1.721 0.99
237_T 461_I 1.704 0.98
216_T 227_H 1.696 0.98
246_C 424_N 1.695 0.98
143_G 356_T 1.687 0.98
87_S 90_S 1.683 0.98
463_L 475_A 1.683 0.98
65_G 495_I 1.68 0.98
266_S 418_A 1.676 0.98
59_M 149_T 1.669 0.98
146_P 324_W 1.66 0.98
216_T 235_I 1.647 0.98
228_T 231_L 1.645 0.98
112_I 116_I 1.64 0.98
62_M 487_N 1.622 0.98
124_E 127_S 1.613 0.98
216_T 232_D 1.612 0.98
248_A 450_I 1.599 0.97
113_Y 374_I 1.592 0.97
431_A 448_V 1.568 0.97
73_P 76_K 1.561 0.97
416_F 420_V 1.559 0.97
68_W 495_I 1.554 0.97
85_E 340_R 1.552 0.97
107_W 110_I 1.536 0.96
150_Y 324_W 1.528 0.96
93_F 97_A 1.528 0.96
234_I 238_C 1.524 0.96
181_E 185_K 1.522 0.96
372_L 376_K 1.495 0.96
344_V 498_A 1.488 0.96
43_V 478_A 1.485 0.96
244_A 453_S 1.481 0.95
264_Y 268_L 1.475 0.95
100_T 146_P 1.473 0.95
116_I 375_D 1.468 0.95
210_L 319_F 1.465 0.95
258_A 424_N 1.459 0.95
396_E 399_A 1.456 0.95
153_L 490_V 1.447 0.95
398_W 411_F 1.442 0.94
60_V 302_F 1.421 0.94
156_A 490_V 1.421 0.94
86_F 337_R 1.42 0.94
422_L 425_A 1.41 0.94
82_E 163_V 1.408 0.94
195_F 486_V 1.407 0.94
24_I 28_L 1.406 0.93
286_F 361_I 1.402 0.93
225_I 231_L 1.394 0.93
187_L 191_I 1.39 0.93
63_L 67_F 1.382 0.93
289_S 364_T 1.375 0.92
398_W 407_T 1.374 0.92
43_V 46_Y 1.373 0.92
454_I 458_I 1.372 0.92
188_F 191_I 1.361 0.92
69_L 344_V 1.35 0.92
28_L 36_A 1.346 0.91
97_A 417_I 1.344 0.91
88_T 346_E 1.334 0.91
406_A 409_W 1.333 0.91
481_C 485_F 1.331 0.91
287_T 291_G 1.324 0.90
374_I 379_I 1.319 0.90
212_T 235_I 1.317 0.90
220_Q 226_P 1.314 0.90
136_A 296_Y 1.308 0.90
241_I 245_I 1.307 0.90
174_T 490_V 1.304 0.90
418_A 422_L 1.294 0.89
180_G 186_G 1.287 0.89
75_A 345_R 1.285 0.89
195_F 479_G 1.281 0.88
247_V 453_S 1.276 0.88
247_V 251_L 1.274 0.88
172_S 243_N 1.273 0.88
55_F 322_A 1.264 0.88
54_A 58_Y 1.26 0.87
427_S 456_V 1.258 0.87
470_K 473_Q 1.256 0.87
155_V 344_V 1.253 0.87
72_G 77_K 1.244 0.86
220_Q 227_H 1.238 0.86
71_F 349_F 1.236 0.86
295_M 299_R 1.234 0.86
176_V 185_K 1.232 0.86
13_K 17_P 1.226 0.85
311_G 315_G 1.218 0.85
29_T 36_A 1.218 0.85
218_C 395_I 1.217 0.85
414_L 417_I 1.217 0.85
138_S 363_W 1.216 0.85
78_R 343_T 1.215 0.85
177_P 180_G 1.215 0.85
107_W 390_V 1.215 0.85
30_V 462_V 1.214 0.85
105_L 415_C 1.212 0.84
71_F 345_R 1.207 0.84
176_V 181_E 1.205 0.84
274_F 279_A 1.193 0.83
169_I 172_S 1.191 0.83
166_M 176_V 1.19 0.83
38_V 42_A 1.178 0.82
179_V 493_S 1.176 0.82
160_F 497_D 1.174 0.82
226_P 231_L 1.169 0.81
207_S 211_A 1.168 0.81
219_M 223_F 1.167 0.81
63_L 148_A 1.166 0.81
258_A 417_I 1.158 0.81
25_L 202_F 1.154 0.80
129_G 132_E 1.151 0.80
46_Y 50_V 1.145 0.79
90_S 256_R 1.142 0.79
286_F 360_W 1.141 0.79
39_V 43_V 1.14 0.79
28_L 32_D 1.14 0.79
436_R 441_G 1.138 0.79
261_V 417_I 1.136 0.79
36_A 40_I 1.136 0.79
216_T 228_T 1.133 0.79
278_G 282_I 1.124 0.78
45_S 49_N 1.114 0.77
74_Y 499_K 1.111 0.77
35_A 39_V 1.109 0.76
100_T 104_V 1.105 0.76
333_I 432_M 1.105 0.76
61_V 491_T 1.105 0.76
178_L 492_L 1.105 0.76
261_V 264_Y 1.104 0.76
13_K 190_T 1.104 0.76
86_F 94_M 1.1 0.76
238_C 242_L 1.098 0.75
231_L 234_I 1.094 0.75
253_K 257_I 1.094 0.75
23_G 27_W 1.094 0.75
404_S 408_M 1.091 0.75
179_V 184_A 1.089 0.75
328_A 487_N 1.087 0.74
53_W 57_W 1.085 0.74
257_I 261_V 1.08 0.74
60_V 301_L 1.078 0.73
20_I 24_I 1.071 0.73
24_I 27_W 1.07 0.73
110_I 312_F 1.068 0.73
144_P 352_V 1.067 0.72
450_I 454_I 1.065 0.72
102_A 211_A 1.065 0.72
137_Y 300_M 1.063 0.72
21_I 198_V 1.06 0.72
229_L 233_A 1.059 0.72
456_V 460_G 1.058 0.72
151_S 351_M 1.056 0.71
364_T 369_N 1.054 0.71
180_G 189_G 1.049 0.71
353_L 357_A 1.049 0.71
89_A 93_F 1.046 0.70
423_V 453_S 1.044 0.70
256_R 260_D 1.042 0.70
38_V 228_T 1.042 0.70
152_F 156_A 1.04 0.70
229_L 465_A 1.039 0.70
244_A 450_I 1.037 0.69
236_I 240_I 1.034 0.69
129_G 133_L 1.033 0.69
64_F 68_W 1.032 0.69
494_F 498_A 1.031 0.69
50_V 280_S 1.028 0.68
317_T 321_W 1.022 0.68
204_M 255_V 1.022 0.68
446_L 449_R 1.019 0.67
206_T 473_Q 1.017 0.67
154_S 159_Y 1.016 0.67
373_L 400_A 1.014 0.67
177_P 193_D 1.013 0.67
216_T 226_P 1.012 0.67
172_S 426_C 1.012 0.67
119_P 125_P 1.01 0.66
100_T 324_W 1.009 0.66
219_M 231_L 1.007 0.66
131_K 375_D 1.006 0.66
109_S 393_A 1.006 0.66
46_Y 51_W 1.005 0.66
125_P 130_A 1.005 0.66
221_W 404_S 1.003 0.66
229_L 232_D 1.001 0.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2wswA10.9981000.015Contact Map0.573
4c7rA30.97821000.043Contact Map0.657
4ainA30.97821000.051Contact Map0.698
2xq2A10.827495.40.963Contact Map0.408
3dh4A40.767994.80.965Contact Map0.352
3l1lA10.714393.60.966Contact Map0.357
3giaA10.684592.90.967Contact Map0.322
4djkA20.736178.10.974Contact Map0.404
2jlnA10.682577.50.974Contact Map0.323
1q90L10.063512.10.984Contact Map0.397

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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