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CAIB - Crotonobetainyl-CoA:carnitine CoA-transferase
UniProt: P31572 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11559
Length: 405 (389)
Sequences: 4621
Seq/Len: 11.88

CAIB
Paralog alert: 0.69 [within 20: 0.12] - ratio of genomes with paralogs
Cluster includes: CAIB FCTA YFDE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
39_E 67_H 4.289 1.00
107_T 110_V 4.022 1.00
30_G 93_I 3.508 1.00
303_H 307_E 3.196 1.00
102_A 107_T 2.944 1.00
75_K 78_G 2.921 1.00
83_L 114_H 2.881 1.00
185_H 188_R 2.772 1.00
111_L 118_L 2.767 1.00
121_A 176_A 2.759 1.00
379_A 396_V 2.75 1.00
121_A 180_A 2.648 1.00
87_E 114_H 2.629 1.00
242_A 304_T 2.613 1.00
388_S 391_D 2.591 1.00
79_R 83_L 2.551 1.00
304_T 307_E 2.524 1.00
71_L 82_F 2.507 1.00
241_C 305_I 2.457 1.00
303_H 308_V 2.442 1.00
377_D 380_A 2.396 1.00
375_G 378_T 2.252 1.00
18_V 86_M 2.243 1.00
186_K 194_E 2.243 1.00
383_K 389_E 2.24 1.00
303_H 311_R 2.239 1.00
112_W 192_K 2.228 1.00
240_K 301_A 2.218 1.00
108_D 112_W 2.205 1.00
299_W 302_T 2.196 1.00
16_R 88_T 2.165 1.00
81_A 387_Y 2.149 1.00
84_K 391_D 2.128 1.00
186_K 362_N 2.123 1.00
36_W 182_A 2.12 1.00
16_R 39_E 2.081 1.00
77_E 398_K 2.033 1.00
18_V 89_T 2.021 1.00
80_E 84_K 2.002 1.00
91_I 180_A 1.993 1.00
69_L 381_I 1.975 1.00
294_E 298_A 1.96 1.00
342_Q 350_T 1.958 1.00
296_L 300_L 1.946 1.00
128_Q 197_D 1.946 1.00
84_K 87_E 1.94 1.00
76_D 79_R 1.929 1.00
92_F 118_L 1.92 1.00
20_S 82_F 1.918 1.00
178_T 181_L 1.903 1.00
101_F 106_I 1.896 1.00
194_E 361_K 1.894 1.00
378_T 382_L 1.888 1.00
306_A 310_E 1.863 1.00
186_K 190_T 1.857 1.00
34_A 65_N 1.837 1.00
186_K 192_K 1.83 1.00
324_T 327_E 1.798 1.00
134_Y 331_N 1.792 1.00
295_K 298_A 1.768 1.00
67_H 384_N 1.764 1.00
67_H 380_A 1.749 1.00
179_A 196_I 1.743 1.00
192_K 362_N 1.736 1.00
394_E 398_K 1.722 1.00
379_A 393_Q 1.72 1.00
69_L 378_T 1.694 1.00
201_Y 334_Y 1.68 1.00
373_S 376_M 1.673 1.00
50_D 53_R 1.671 1.00
15_L 184_L 1.669 1.00
137_L 313_A 1.665 1.00
119_V 187_V 1.663 1.00
194_E 363_N 1.643 1.00
134_Y 137_L 1.641 1.00
122_H 195_S 1.617 1.00
71_L 78_G 1.615 1.00
72_N 75_K 1.608 1.00
259_C 263_I 1.604 1.00
148_S 204_M 1.599 1.00
202_E 337_R 1.596 1.00
19_F 30_G 1.59 1.00
237_G 293_E 1.567 1.00
391_D 394_E 1.544 1.00
110_V 113_Q 1.528 1.00
168_A 204_M 1.519 1.00
265_L 268_L 1.511 1.00
49_A 53_R 1.506 1.00
139_A 200_M 1.505 1.00
86_M 115_N 1.495 1.00
86_M 111_L 1.481 1.00
35_E 64_R 1.478 1.00
310_E 314_E 1.449 1.00
239_Y 293_E 1.439 1.00
305_I 327_E 1.428 1.00
393_Q 397_S 1.427 1.00
300_L 308_V 1.424 1.00
15_L 185_H 1.423 1.00
330_S 335_V 1.418 1.00
71_L 81_A 1.416 1.00
299_W 308_V 1.408 1.00
326_P 330_S 1.4 0.99
261_K 269_L 1.39 0.99
333_Q 336_A 1.384 0.99
185_H 189_E 1.357 0.99
240_K 297_D 1.356 0.99
86_M 114_H 1.339 0.99
83_L 106_I 1.322 0.99
307_E 311_R 1.316 0.99
279_Q 282_H 1.314 0.99
94_E 122_H 1.301 0.99
190_T 362_N 1.296 0.99
20_S 92_F 1.296 0.99
372_P 377_D 1.295 0.99
342_Q 352_K 1.294 0.99
108_D 120_I 1.289 0.99
271_T 274_I 1.287 0.99
146_A 247_V 1.287 0.99
240_K 300_L 1.282 0.99
123_L 176_A 1.281 0.99
387_Y 392_I 1.278 0.99
280_L 283_R 1.278 0.99
179_A 358_P 1.271 0.99
29_A 177_T 1.267 0.99
256_I 260_F 1.236 0.98
91_I 119_V 1.234 0.98
266_A 269_L 1.226 0.98
184_L 188_R 1.222 0.98
199_A 202_E 1.22 0.98
117_K 188_R 1.218 0.98
261_K 266_A 1.217 0.98
73_I 104_R 1.212 0.98
241_C 246_I 1.209 0.98
117_K 187_V 1.2 0.98
379_A 383_K 1.196 0.98
305_I 321_K 1.193 0.98
84_K 387_Y 1.193 0.98
77_E 80_E 1.185 0.98
146_A 320_A 1.182 0.98
307_E 310_E 1.179 0.98
10_G 13_A 1.177 0.98
323_L 327_E 1.176 0.98
205_L 328_L 1.175 0.98
68_A 372_P 1.173 0.98
20_S 101_F 1.167 0.97
171_F 207_M 1.161 0.97
282_H 285_E 1.153 0.97
372_P 376_M 1.153 0.97
17_V 91_I 1.15 0.97
126_F 147_F 1.148 0.97
262_D 311_R 1.145 0.97
253_I 257_E 1.138 0.97
265_L 299_W 1.138 0.97
82_F 106_I 1.128 0.97
344_Q 350_T 1.126 0.97
43_I 69_L 1.12 0.96
265_L 295_K 1.114 0.96
197_D 337_R 1.105 0.96
175_T 206_R 1.102 0.96
11_P 360_F 1.102 0.96
396_V 401_A 1.098 0.96
158_D 224_R 1.094 0.96
181_L 185_H 1.093 0.96
230_D 233_Y 1.089 0.96
252_G 255_Q 1.089 0.96
65_N 368_W 1.086 0.96
65_N 369_R 1.083 0.96
108_D 195_S 1.077 0.95
81_A 400_L 1.077 0.95
49_A 52_I 1.073 0.95
134_Y 147_F 1.071 0.95
257_E 261_K 1.069 0.95
205_L 334_Y 1.064 0.95
156_D 159_Q 1.055 0.95
100_A 103_R 1.048 0.94
141_N 145_Q 1.046 0.94
184_L 187_V 1.038 0.94
323_L 331_N 1.035 0.94
74_F 104_R 1.032 0.94
370_G 376_M 1.028 0.94
147_F 331_N 1.025 0.93
70_S 378_T 1.019 0.93
254_T 258_E 1.013 0.93
83_L 87_E 1.01 0.93
194_E 362_N 1.009 0.93
85_L 385_I 1.004 0.93
16_R 41_I 1.003 0.93
291_L 294_E 1.002 0.92
83_L 110_V 1.002 0.92
311_R 314_E 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1xk7A30.99511000.04Contact Map0.765
1q7eA10.96541000.063Contact Map0.745
2vjqA40.95061000.07Contact Map0.823
3ubmA40.97041000.072Contact Map0.791
4hl6A60.92351000.109Contact Map0.844
4ed9A10.9161000.109Contact Map0.738
2yimA40.87651000.156Contact Map0.748
2g04A60.87161000.181Contact Map0.759
1vl6A40.503780.40.962Contact Map0.491
2a9fA20.498858.60.967Contact Map0.295

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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