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CHAA - Sodium/proton antiporter ChaA
UniProt: P31801 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11753
Length: 366 (326)
Sequences: 2174
Seq/Len: 6.67

CHAA
Paralog alert: 0.55 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: CHAA YRBG
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
113_I 117_G 3.019 1.00
113_I 266_L 2.93 1.00
175_A 307_T 2.828 1.00
116_G 331_A 2.728 1.00
76_I 79_L 2.267 1.00
167_S 174_V 1.994 1.00
250_D 256_V 1.978 1.00
176_L 308_L 1.96 1.00
142_Q 332_S 1.927 1.00
92_L 95_T 1.904 1.00
182_Y 301_L 1.895 1.00
91_A 95_T 1.867 1.00
124_L 354_L 1.836 1.00
52_S 55_F 1.817 1.00
224_A 228_I 1.804 1.00
124_L 351_A 1.802 1.00
123_L 350_G 1.795 1.00
153_I 174_V 1.768 1.00
341_S 349_N 1.755 1.00
244_S 248_L 1.74 1.00
187_L 191_K 1.723 1.00
334_V 356_L 1.711 1.00
249_L 259_T 1.673 1.00
82_V 271_E 1.672 1.00
56_S 226_W 1.655 1.00
110_I 114_V 1.649 1.00
78_S 286_R 1.648 1.00
179_A 183_G 1.628 1.00
239_K 243_S 1.621 1.00
88_L 92_L 1.62 1.00
126_G 133_Q 1.605 1.00
60_H 230_H 1.603 1.00
53_S 237_V 1.591 1.00
183_G 187_L 1.564 0.99
150_L 299_I 1.551 0.99
298_T 302_T 1.546 0.99
116_G 353_H 1.519 0.99
87_S 94_A 1.495 0.99
85_E 271_E 1.464 0.99
172_L 311_F 1.446 0.99
184_V 351_A 1.439 0.99
111_I 298_T 1.438 0.99
176_L 180_A 1.436 0.99
88_L 107_L 1.433 0.99
52_S 56_S 1.431 0.99
91_A 94_A 1.419 0.99
117_G 266_L 1.416 0.99
219_S 222_W 1.408 0.99
204_D 207_D 1.394 0.99
172_L 309_I 1.386 0.98
145_I 300_S 1.381 0.98
225_I 229_I 1.379 0.98
294_S 297_A 1.377 0.98
342_T 349_N 1.375 0.98
301_L 305_V 1.374 0.98
204_D 209_D 1.373 0.98
274_G 278_A 1.347 0.98
348_L 352_A 1.346 0.98
261_F 287_A 1.345 0.98
346_N 349_N 1.342 0.98
114_V 295_V 1.338 0.98
221_L 225_I 1.334 0.98
244_S 247_T 1.331 0.98
322_G 325_E 1.32 0.98
268_L 297_A 1.308 0.98
110_I 268_L 1.305 0.98
126_G 282_N 1.294 0.97
101_T 105_D 1.291 0.97
54_A 81_V 1.291 0.97
268_L 272_G 1.291 0.97
101_T 318_Q 1.289 0.97
231_L 235_I 1.283 0.97
46_A 237_V 1.281 0.97
175_A 304_P 1.278 0.97
355_A 359_A 1.271 0.97
52_S 59_R 1.261 0.97
166_F 169_G 1.255 0.97
63_V 67_R 1.255 0.97
64_L 227_L 1.249 0.97
107_L 303_V 1.245 0.96
99_A 256_V 1.241 0.96
83_I 302_T 1.239 0.96
80_S 182_Y 1.237 0.96
254_A 258_F 1.228 0.96
245_L 264_A 1.222 0.96
114_V 294_S 1.222 0.96
120_G 350_G 1.221 0.96
80_S 297_A 1.215 0.96
156_V 160_A 1.207 0.96
127_G 347_V 1.202 0.95
62_D 73_G 1.199 0.95
122_S 275_A 1.187 0.95
89_I 235_I 1.184 0.95
108_Y 303_V 1.182 0.95
248_L 252_M 1.172 0.95
357_F 360_Y 1.171 0.94
89_I 93_M 1.162 0.94
50_I 58_V 1.159 0.94
238_T 257_A 1.156 0.94
114_V 267_I 1.15 0.94
107_L 307_T 1.147 0.94
89_I 94_A 1.147 0.94
89_I 92_L 1.146 0.94
109_S 116_G 1.144 0.94
233_A 236_A 1.134 0.93
135_M 345_T 1.125 0.93
113_I 238_T 1.113 0.92
205_S 209_D 1.112 0.92
208_D 212_H 1.112 0.92
54_A 62_D 1.102 0.92
274_G 299_I 1.097 0.92
106_T 264_A 1.096 0.92
204_D 210_P 1.095 0.91
81_V 294_S 1.093 0.91
127_G 345_T 1.092 0.91
65_A 73_G 1.091 0.91
79_L 297_A 1.082 0.91
265_L 295_V 1.081 0.91
190_T 193_H 1.077 0.91
222_W 226_W 1.077 0.91
78_S 298_T 1.076 0.91
122_S 279_V 1.074 0.90
322_G 329_M 1.069 0.90
199_Y 204_D 1.069 0.90
119_V 335_L 1.065 0.90
231_L 261_F 1.062 0.90
172_L 308_L 1.057 0.89
200_E 205_S 1.056 0.89
123_L 345_T 1.055 0.89
268_L 298_T 1.053 0.89
184_V 313_T 1.053 0.89
247_T 250_D 1.052 0.89
92_L 96_G 1.052 0.89
150_L 314_G 1.042 0.89
64_L 223_H 1.039 0.88
333_L 337_H 1.037 0.88
46_A 49_G 1.036 0.88
206_D 209_D 1.031 0.88
102_L 357_F 1.028 0.88
57_V 234_V 1.027 0.88
241_N 357_F 1.024 0.87
104_R 303_V 1.023 0.87
79_L 82_V 1.021 0.87
225_I 358_A 1.02 0.87
288_M 338_I 1.019 0.87
62_D 283_Q 1.015 0.87
148_F 181_M 1.011 0.86
88_L 95_T 1.008 0.86
222_W 225_I 1.007 0.86
89_I 238_T 1.006 0.86
55_F 59_R 1.005 0.86
179_A 308_L 1 0.86
113_I 357_F 1 0.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4k1cA20.97541000.257Contact Map0.542
4kjrA20.94261000.293Contact Map0.551
3v5uA10.81151000.37Contact Map0.518
4kppA20.90981000.401Contact Map0.54
4j05A20.46456.20.971Contact Map0.312
3pjzA20.21864.20.973Contact Map0.15
2jlnA10.45634.10.973Contact Map0.153
4i0uA100.172140.973Contact Map0.541
1pw4A10.461740.973Contact Map0.344
3o7qA10.43173.70.973Contact Map0.241

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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