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ACTP - Cation/acetate symporter ActP
UniProt: P32705 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11942
Length: 549 (503)
Sequences: 4748
Seq/Len: 9.44

ACTP
Paralog alert: 0.71 [within 20: 0.10] - ratio of genomes with paralogs
Cluster includes: ACTP PANF PUTP YIDK
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
467_L 510_G 5.426 1.00
393_K 400_E 4.145 1.00
397_T 400_E 3.773 1.00
290_D 293_E 3.626 1.00
467_L 506_V 3.48 1.00
456_L 511_I 3.461 1.00
388_Y 396_A 3.447 1.00
512_W 516_A 3.412 1.00
193_M 413_G 3.276 1.00
460_G 515_S 3.25 1.00
510_G 514_F 3.109 1.00
514_F 518_D 3.084 1.00
463_M 514_F 2.9 1.00
457_T 518_D 2.841 1.00
48_G 52_W 2.757 1.00
226_V 318_G 2.753 1.00
127_N 291_A 2.729 1.00
464_G 511_I 2.677 1.00
471_T 506_V 2.677 1.00
180_N 183_I 2.56 1.00
459_R 518_D 2.435 1.00
449_L 511_I 2.4 1.00
138_S 147_R 2.385 1.00
457_T 460_G 2.37 1.00
201_M 287_T 2.348 1.00
224_F 228_K 2.287 1.00
414_V 418_I 2.282 1.00
189_G 417_I 2.281 1.00
403_R 407_I 2.225 1.00
236_N 239_S 2.188 1.00
453_W 512_W 2.118 1.00
70_I 205_T 2.113 1.00
33_W 37_I 2.102 1.00
186_V 190_V 2.077 1.00
460_G 464_G 2.044 1.00
453_W 456_L 2.03 1.00
44_V 48_G 2.02 1.00
399_R 403_R 2.02 1.00
455_K 516_A 2.016 1.00
388_Y 393_K 2.014 1.00
358_G 362_A 2.009 1.00
136_V 450_S 1.996 1.00
509_L 513_F 1.995 1.00
62_D 67_G 1.982 1.00
453_W 516_A 1.971 1.00
289_S 293_E 1.947 1.00
463_M 510_G 1.934 1.00
141_L 456_L 1.934 1.00
407_I 411_I 1.913 1.00
383_V 387_L 1.912 1.00
396_A 400_E 1.87 1.00
446_I 461_A 1.865 1.00
61_S 68_G 1.865 1.00
457_T 515_S 1.86 1.00
41_I 45_F 1.852 1.00
65_T 68_G 1.85 1.00
385_H 389_A 1.832 1.00
388_Y 400_E 1.827 1.00
393_K 396_A 1.808 1.00
74_Q 209_I 1.807 1.00
218_G 363_V 1.789 1.00
454_S 531_R 1.765 1.00
293_E 296_K 1.743 1.00
383_V 408_T 1.738 1.00
199_G 203_A 1.738 1.00
459_R 463_M 1.704 1.00
345_V 348_A 1.694 1.00
456_L 460_G 1.674 1.00
449_L 508_F 1.64 1.00
470_I 474_V 1.631 1.00
388_Y 404_V 1.615 1.00
86_A 168_G 1.613 1.00
460_G 514_F 1.61 1.00
66_A 201_M 1.598 1.00
170_G 185_V 1.58 1.00
319_A 343_A 1.579 1.00
64_Y 405_S 1.564 1.00
132_T 381_S 1.541 1.00
376_T 413_G 1.54 1.00
82_D 374_G 1.539 1.00
208_Q 284_R 1.531 1.00
388_Y 392_F 1.52 1.00
153_G 469_L 1.517 1.00
45_F 49_I 1.516 1.00
49_I 210_I 1.509 1.00
75_N 288_V 1.504 1.00
453_W 460_G 1.497 1.00
204_T 207_V 1.496 1.00
147_R 386_D 1.493 1.00
392_F 396_A 1.48 1.00
384_S 405_S 1.465 1.00
379_G 412_L 1.461 1.00
505_T 509_L 1.453 1.00
135_D 386_D 1.449 1.00
455_K 519_N 1.442 1.00
396_A 401_E 1.439 1.00
77_L 209_I 1.439 1.00
403_R 406_K 1.431 1.00
389_A 401_E 1.43 1.00
78_A 374_G 1.43 1.00
45_F 210_I 1.406 0.99
36_I 40_L 1.4 0.99
292_R 295_R 1.391 0.99
239_S 243_A 1.387 0.99
236_N 240_E 1.382 0.99
235_N 239_S 1.381 0.99
455_K 520_S 1.372 0.99
441_S 445_P 1.359 0.99
140_R 453_W 1.359 0.99
207_V 211_K 1.355 0.99
48_G 51_Y 1.353 0.99
192_M 372_V 1.35 0.99
141_L 449_L 1.345 0.99
46_T 210_I 1.342 0.99
94_A 341_N 1.339 0.99
457_T 514_F 1.336 0.99
130_R 139_Y 1.33 0.99
515_S 518_D 1.326 0.99
189_G 413_G 1.325 0.99
192_M 369_L 1.322 0.99
464_G 507_A 1.316 0.99
463_M 467_L 1.313 0.99
348_A 353_G 1.312 0.99
323_V 350_A 1.307 0.99
121_I 448_L 1.305 0.99
138_S 390_N 1.302 0.99
508_F 512_W 1.294 0.99
450_S 461_A 1.294 0.99
510_G 513_F 1.288 0.99
400_E 404_V 1.282 0.99
396_A 404_V 1.279 0.99
195_Y 369_L 1.279 0.99
145_P 462_M 1.276 0.99
157_V 438_I 1.269 0.99
192_M 373_A 1.269 0.99
183_I 186_V 1.258 0.98
35_A 355_L 1.258 0.98
408_T 411_I 1.256 0.98
400_E 403_R 1.252 0.98
292_R 296_K 1.243 0.98
348_A 360_I 1.234 0.98
460_G 463_M 1.232 0.98
37_I 41_I 1.229 0.98
525_R 529_L 1.227 0.98
82_D 208_Q 1.227 0.98
456_L 515_S 1.217 0.98
78_A 284_R 1.21 0.98
150_S 465_G 1.206 0.98
81_G 284_R 1.203 0.98
85_S 89_F 1.203 0.98
72_G 293_E 1.194 0.98
185_V 417_I 1.192 0.98
459_R 514_F 1.191 0.98
369_L 373_A 1.189 0.98
136_V 140_R 1.186 0.97
220_S 224_F 1.167 0.97
76_G 300_Y 1.165 0.97
467_L 471_T 1.163 0.97
57_V 62_D 1.163 0.97
208_Q 373_A 1.16 0.97
453_W 515_S 1.16 0.97
96_V 103_G 1.158 0.97
195_Y 203_A 1.156 0.97
367_T 370_A 1.144 0.97
166_M 189_G 1.14 0.97
141_L 511_I 1.13 0.96
66_A 70_I 1.124 0.96
140_R 450_S 1.124 0.96
78_A 82_D 1.123 0.96
346_H 350_A 1.122 0.96
152_C 156_V 1.118 0.96
462_M 466_W 1.113 0.96
207_V 373_A 1.109 0.96
80_A 304_F 1.106 0.96
513_F 516_A 1.105 0.96
523_G 528_E 1.102 0.96
169_A 188_V 1.098 0.95
135_D 385_H 1.098 0.95
239_S 242_M 1.097 0.95
446_I 465_G 1.096 0.95
453_W 457_T 1.094 0.95
240_E 243_A 1.093 0.95
141_L 450_S 1.091 0.95
142_K 458_T 1.089 0.95
143_Q 458_T 1.085 0.95
124_R 127_N 1.084 0.95
174_E 178_G 1.083 0.95
39_F 365_F 1.083 0.95
466_W 470_I 1.082 0.95
42_F 366_A 1.08 0.95
78_A 205_T 1.073 0.95
179_L 184_A 1.072 0.95
221_F 225_M 1.071 0.95
195_Y 373_A 1.068 0.95
506_V 510_G 1.068 0.95
122_A 294_A 1.068 0.95
384_S 401_E 1.068 0.95
208_Q 374_G 1.066 0.94
190_V 194_M 1.065 0.94
152_C 387_L 1.061 0.94
512_W 515_S 1.06 0.94
96_V 317_F 1.054 0.94
211_K 366_A 1.052 0.94
358_G 363_V 1.047 0.94
223_A 311_L 1.047 0.94
211_K 373_A 1.046 0.94
186_V 421_V 1.046 0.94
459_R 517_T 1.044 0.94
383_V 412_L 1.043 0.94
377_L 380_A 1.038 0.93
398_E 401_E 1.025 0.93
182_H 186_V 1.02 0.93
442_C 507_A 1.019 0.93
449_L 512_W 1.016 0.92
197_L 410_L 1.014 0.92
35_A 38_M 1.013 0.92
149_L 465_G 1.006 0.92
352_G 356_F 1.003 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2xq2A10.91991000.358Contact Map0.656
3dh4A40.87981000.395Contact Map0.59
3l1lA10.783299.20.894Contact Map0.394
3giaA10.785198.60.915Contact Map0.41
2jlnA10.786998.20.924Contact Map0.405
4djkA20.8342980.929Contact Map0.324
2wswA10.783295.30.95Contact Map0.352
4c7rA30.852594.70.951Contact Map0.372
4ainA30.8306940.953Contact Map0.454
3dinD20.11666.90.98Contact Map0.127

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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