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ALSE - D-allulose-6-phosphate 3-epimerase
UniProt: P32719 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11957
Length: 231 (212)
Sequences: 2079
Seq/Len: 9.81

ALSE
Paralog alert: 0.20 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: ALSE RPE SGCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
14_K 17_E 3.537 1.00
181_Y 192_F 3.028 1.00
161_R 168_Y 2.841 1.00
176_C 184_L 2.728 1.00
169_E 190_D 2.471 1.00
62_C 81_A 2.453 1.00
120_E 123_K 2.355 1.00
148_P 183_K 2.352 1.00
203_A 207_D 2.266 1.00
84_I 107_M 2.218 1.00
123_K 156_E 2.162 1.00
199_L 205_N 2.062 1.00
67_T 93_G 2.049 1.00
37_H 67_T 2.016 1.00
182_E 186_A 1.99 1.00
31_I 49_V 1.97 1.00
158_K 162_E 1.938 1.00
132_I 157_L 1.917 1.00
96_F 128_K 1.909 1.00
89_E 117_T 1.903 1.00
134_V 150_M 1.841 1.00
159_A 163_R 1.832 1.00
68_R 71_D 1.8 1.00
85_T 112_I 1.795 1.00
152_D 155_A 1.786 1.00
146_F 151_L 1.779 1.00
86_L 95_A 1.778 1.00
74_A 78_R 1.764 1.00
77_A 107_M 1.755 1.00
50_S 78_R 1.75 1.00
22_I 29_F 1.731 1.00
74_A 101_E 1.728 1.00
123_K 160_W 1.724 1.00
201_N 204_E 1.713 1.00
110_G 131_K 1.701 1.00
28_Y 191_V 1.701 1.00
136_T 150_M 1.698 1.00
21_F 202_H 1.644 1.00
70_Q 98_L 1.634 1.00
85_T 131_K 1.617 1.00
101_E 104_R 1.608 1.00
103_R 109_V 1.606 1.00
185_M 192_F 1.573 1.00
37_H 68_R 1.556 1.00
161_R 190_D 1.516 1.00
70_Q 92_N 1.514 1.00
88_P 121_A 1.467 1.00
177_N 180_T 1.465 1.00
109_V 130_D 1.46 1.00
74_A 105_H 1.452 1.00
180_T 184_L 1.45 1.00
20_E 23_D 1.443 1.00
27_D 210_W 1.434 1.00
44_L 48_F 1.432 1.00
16_K 20_E 1.417 1.00
53_K 60_L 1.392 0.99
53_K 82_D 1.391 0.99
59_P 83_F 1.391 0.99
158_K 161_R 1.378 0.99
114_N 138_D 1.37 0.99
119_V 157_L 1.367 0.99
134_V 157_L 1.362 0.99
49_V 60_L 1.36 0.99
19_I 52_V 1.339 0.99
18_Q 202_H 1.322 0.99
99_I 128_K 1.313 0.99
100_D 104_R 1.308 0.99
31_I 60_L 1.304 0.99
204_E 208_E 1.289 0.99
83_F 108_K 1.288 0.99
116_E 138_D 1.287 0.99
7_L 29_F 1.281 0.99
71_D 75_Q 1.279 0.99
94_Q 138_D 1.258 0.99
95_A 111_L 1.24 0.98
77_A 105_H 1.238 0.98
94_Q 97_R 1.236 0.98
171_E 193_I 1.233 0.98
18_Q 21_F 1.232 0.98
194_V 197_S 1.225 0.98
4_S 28_Y 1.185 0.98
119_V 124_Y 1.174 0.97
28_Y 169_E 1.17 0.97
73_I 105_H 1.169 0.97
178_Q 197_S 1.153 0.97
126_I 166_L 1.136 0.97
95_A 125_Y 1.135 0.97
155_A 186_A 1.129 0.97
131_K 191_V 1.119 0.96
27_D 59_P 1.107 0.96
31_I 44_L 1.086 0.95
100_D 128_K 1.085 0.95
83_F 131_K 1.081 0.95
183_K 186_A 1.078 0.95
111_L 129_A 1.074 0.95
120_E 156_E 1.073 0.95
157_L 170_I 1.068 0.95
204_E 207_D 1.057 0.95
99_I 103_R 1.057 0.95
95_A 116_E 1.055 0.94
2_K 28_Y 1.048 0.94
154_L 170_I 1.04 0.94
154_L 172_V 1.036 0.94
56_A 60_L 1.033 0.94
8_M 142_A 1.023 0.93
99_I 125_Y 1.022 0.93
17_E 21_F 1.015 0.93
155_A 159_A 1.014 0.93
151_L 183_K 1.013 0.93
7_L 31_I 1.011 0.93
207_D 211_R 1.011 0.93
38_F 89_E 1.005 0.92
34_M 39_V 1.005 0.92
111_L 125_Y 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3cu2A20.90481000.391Contact Map0.649
3ctlA60.9741000.444Contact Map0.822
3inpA10.93071000.501Contact Map0.704
1rpxA30.93071000.51Contact Map0.777
2yyuA20.91771000.511Contact Map0.351
1dbtA30.89611000.511Contact Map0.389
4df0A20.83981000.513Contact Map0.331
4muzA20.87451000.514Contact Map0.391
4dbdA10.90911000.514Contact Map0.419
1tqjA60.95671000.516Contact Map0.819

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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