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ALSC - D-allose transport system permease protein AlsC
UniProt: P32720 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11958
Length: 326 (301)
Sequences: 12753
Seq/Len: 42.37

ALSC
Paralog alert: 0.92 [within 20: 0.64] - ratio of genomes with paralogs
Cluster includes: ALSC ARAH LIVH LSRC LSRD MGLC RBSC XYLH YJFF YPHD YTFT
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
113_V 233_V 4.001 1.00
117_G 229_I 3.83 1.00
210_K 224_I 3.031 1.00
219_D 222_F 2.778 1.00
117_G 233_V 2.745 1.00
120_G 232_G 2.708 1.00
93_V 115_V 2.69 1.00
116_G 232_G 2.592 1.00
64_V 183_S 2.502 1.00
203_I 227_V 2.487 1.00
116_G 236_G 2.456 1.00
121_A 229_I 2.447 1.00
71_F 282_V 2.33 1.00
206_L 223_H 2.24 1.00
192_F 196_R 2.208 1.00
129_W 221_K 2.206 1.00
222_F 226_V 2.174 1.00
113_V 237_L 2.132 1.00
123_N 141_T 2.12 1.00
199_L 226_V 2.099 1.00
260_Y 293_N 2.092 1.00
66_I 261_A 2.088 1.00
193_L 199_L 2.087 1.00
104_P 107_A 2.076 1.00
97_L 111_G 2.06 1.00
189_I 193_L 2.058 1.00
199_L 203_I 1.9 1.00
121_A 225_L 1.873 1.00
218_I 223_H 1.867 1.00
60_S 290_G 1.844 1.00
88_A 149_T 1.789 1.00
191_W 195_T 1.782 1.00
202_N 223_H 1.75 1.00
205_A 213_A 1.733 1.00
73_A 231_S 1.677 1.00
72_F 190_L 1.676 1.00
109_M 240_V 1.67 1.00
187_A 283_V 1.662 1.00
78_G 134_P 1.649 1.00
124_G 225_L 1.647 1.00
188_L 192_F 1.631 1.00
268_G 281_S 1.615 1.00
65_L 238_A 1.61 1.00
41_S 44_P 1.597 1.00
106_L 110_I 1.583 1.00
124_G 128_N 1.583 1.00
198_R 202_N 1.581 1.00
76_V 227_V 1.579 1.00
60_S 287_L 1.567 1.00
72_F 227_V 1.555 1.00
211_N 214_F 1.546 1.00
210_K 214_F 1.542 1.00
66_I 87_L 1.54 1.00
67_G 282_V 1.537 1.00
202_N 218_I 1.523 1.00
64_V 286_G 1.519 1.00
110_I 114_L 1.502 1.00
206_L 220_V 1.485 1.00
114_L 118_A 1.472 1.00
225_L 229_I 1.455 1.00
143_A 146_R 1.453 1.00
78_G 228_F 1.442 1.00
181_I 185_I 1.428 1.00
141_T 145_F 1.423 1.00
202_N 213_A 1.404 0.99
226_V 230_I 1.401 0.99
87_L 242_S 1.394 0.99
229_I 233_V 1.391 0.99
278_R 281_S 1.39 0.99
185_I 189_I 1.39 0.99
239_G 243_T 1.39 0.99
75_L 204_Y 1.38 0.99
75_L 277_G 1.373 0.99
270_T 282_V 1.368 0.99
65_L 241_V 1.365 0.99
52_N 294_N 1.363 0.99
94_T 112_G 1.362 0.99
266_I 272_F 1.356 0.99
85_A 146_R 1.346 0.99
260_Y 310_M 1.342 0.99
94_T 240_V 1.34 0.99
71_F 270_T 1.339 0.99
68_M 190_L 1.336 0.99
69_G 234_C 1.332 0.99
89_L 119_L 1.328 0.99
114_L 117_G 1.327 0.99
64_V 283_V 1.325 0.99
125_C 129_W 1.321 0.99
108_A 112_G 1.32 0.99
128_N 221_K 1.318 0.99
226_V 229_I 1.315 0.99
113_V 240_V 1.309 0.99
39_F 295_G 1.3 0.99
214_F 221_K 1.279 0.99
83_V 235_A 1.265 0.99
92_M 251_P 1.257 0.99
70_E 83_V 1.257 0.99
112_G 116_G 1.247 0.99
70_E 265_A 1.242 0.98
126_L 137_I 1.223 0.98
134_P 228_F 1.223 0.98
81_L 262_I 1.22 0.98
203_I 223_H 1.219 0.98
103_D 107_A 1.209 0.98
232_G 236_G 1.208 0.98
146_R 258_E 1.207 0.98
67_G 265_A 1.204 0.98
190_L 230_I 1.198 0.98
118_A 122_I 1.193 0.98
117_G 236_G 1.184 0.98
186_V 234_C 1.183 0.98
268_G 285_G 1.183 0.98
118_A 121_A 1.179 0.98
236_G 240_V 1.175 0.98
72_F 194_T 1.171 0.98
174_I 181_I 1.168 0.97
294_N 297_N 1.16 0.97
213_A 218_I 1.16 0.97
184_L 188_L 1.154 0.97
91_G 253_A 1.151 0.97
263_A 314_I 1.145 0.97
129_W 225_L 1.136 0.97
91_G 249_A 1.126 0.97
38_I 42_L 1.124 0.97
90_S 239_G 1.115 0.96
131_G 210_K 1.115 0.96
78_G 224_I 1.113 0.96
119_L 145_F 1.11 0.96
199_L 230_I 1.108 0.96
264_S 285_G 1.084 0.96
70_E 261_A 1.081 0.95
280_F 284_I 1.073 0.95
67_G 264_S 1.061 0.95
233_V 237_L 1.058 0.95
93_V 97_L 1.055 0.95
85_A 142_N 1.054 0.95
107_A 110_I 1.053 0.95
103_D 111_G 1.052 0.95
98_M 108_A 1.049 0.94
84_G 258_E 1.046 0.94
97_L 103_D 1.044 0.94
74_I 265_A 1.04 0.94
312_G 316_A 1.039 0.94
183_S 187_A 1.026 0.94
206_L 213_A 1.024 0.93
28_T 32_L 1.023 0.93
116_G 120_G 1.013 0.93
67_G 286_G 1.007 0.93
60_S 286_G 1.005 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4g1uA20.914194.60.906Contact Map0.534
2nq2A20.8589940.909Contact Map0.516
2qi9A20.877389.60.919Contact Map0.583
1u7gA10.595160.963Contact Map0.347
1q90R10.14421.90.971Contact Map0.46
1wr1B10.08591.70.972Contact Map
2ksfA10.29751.60.972Contact Map0.347
2ls2A10.07671.60.972Contact Map0.318
2b2hA10.67181.30.974Contact Map0.251
2kogA10.14421.30.974Contact Map0.067

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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