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ALSA - D-allose import ATP-binding protein AlsA
UniProt: P32721 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11959
Length: 510 (499)
Sequences: 13708
Seq/Len: 27.47

ALSA
Paralog alert: 0.93 [within 20: 0.27] - ratio of genomes with paralogs
Cluster includes: ALSA ARAG GSIA LSRA MGLA MODF RBSA UUP XYLG YBHF YBIT YEJF YHES YJJK YPHE YTFR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
32_E 214_R 4.541 1.00
270_N 281_D 4.408 1.00
10_G 23_S 4.376 1.00
267_E 285_S 4.177 1.00
22_K 222_S 4.026 1.00
269_R 319_E 3.947 1.00
290_E 478_R 3.744 1.00
9_A 61_T 3.636 1.00
306_M 465_V 3.555 1.00
34_H 216_T 3.376 1.00
268_V 271_V 3.357 1.00
61_T 68_S 3.332 1.00
7_S 27_T 3.23 1.00
267_E 321_R 3.225 1.00
8_M 11_I 3.201 1.00
19_H 22_K 2.971 1.00
319_E 326_D 2.962 1.00
307_N 313_D 2.891 1.00
280_R 486_R 2.791 1.00
7_S 63_T 2.684 1.00
292_L 480_A 2.639 1.00
35_A 212_C 2.631 1.00
293_G 476_C 2.574 1.00
323_N 429_E 2.566 1.00
118_D 121_E 2.563 1.00
339_G 429_E 2.558 1.00
125_R 128_M 2.552 1.00
393_R 403_V 2.531 1.00
65_N 165_K 2.519 1.00
228_I 231_D 2.491 1.00
268_V 284_F 2.457 1.00
12_G 23_S 2.431 1.00
273_S 308_C 2.413 1.00
189_N 210_R 2.401 1.00
132_R 194_E 2.325 1.00
270_N 283_S 2.31 1.00
269_R 321_R 2.278 1.00
48_M 201_I 2.27 1.00
264_T 267_E 2.242 1.00
14_S 19_H 2.23 1.00
141_E 145_N 2.227 1.00
10_G 25_N 2.209 1.00
466_S 472_I 2.184 1.00
288_R 429_E 2.145 1.00
81_G 165_K 2.129 1.00
123_R 140_D 2.127 1.00
121_E 125_R 2.119 1.00
15_F 55_H 2.057 1.00
355_N 408_T 2.028 1.00
308_C 315_R 2.024 1.00
305_L 482_F 2.006 1.00
306_M 432_I 1.987 1.00
12_G 19_H 1.961 1.00
273_S 316_A 1.96 1.00
125_R 163_D 1.944 1.00
272_T 281_D 1.942 1.00
454_Q 458_D 1.94 1.00
272_T 317_G 1.938 1.00
480_A 490_I 1.929 1.00
8_M 26_L 1.916 1.00
263_E 288_R 1.899 1.00
96_T 99_E 1.852 1.00
71_K 80_L 1.843 1.00
29_Y 32_E 1.841 1.00
216_T 223_S 1.829 1.00
212_C 229_V 1.809 1.00
127_A 131_L 1.787 1.00
277_K 280_R 1.775 1.00
287_C 290_E 1.771 1.00
8_M 51_L 1.771 1.00
464_M 475_V 1.767 1.00
73_D 76_L 1.726 1.00
124_V 128_M 1.722 1.00
83_G 159_T 1.714 1.00
269_R 283_S 1.711 1.00
286_V 292_L 1.71 1.00
30_P 165_K 1.704 1.00
138_D 141_E 1.703 1.00
284_F 480_A 1.7 1.00
9_A 63_T 1.695 1.00
391_N 395_L 1.687 1.00
188_M 198_I 1.675 1.00
293_G 472_I 1.674 1.00
392_Q 425_C 1.663 1.00
94_E 144_A 1.661 1.00
101_L 161_M 1.65 1.00
227_G 232_V 1.63 1.00
28_V 166_V 1.627 1.00
12_G 59_K 1.613 1.00
225_C 240_L 1.601 1.00
310_F 432_I 1.596 1.00
236_D 239_R 1.595 1.00
33_I 188_M 1.583 1.00
429_E 460_K 1.58 1.00
395_L 454_Q 1.569 1.00
359_A 404_N 1.568 1.00
142_K 145_N 1.568 1.00
264_T 285_S 1.566 1.00
480_A 487_L 1.559 1.00
392_Q 421_S 1.552 1.00
68_S 71_K 1.552 1.00
286_V 461_V 1.552 1.00
410_L 418_V 1.55 1.00
393_R 400_C 1.544 1.00
132_R 190_Q 1.538 1.00
489_Q 505_W 1.535 1.00
407_I 418_V 1.523 1.00
402_S 405_Q 1.522 1.00
165_K 196_T 1.519 1.00
85_I 169_M 1.519 1.00
5_Y 197_A 1.509 1.00
10_G 59_K 1.499 1.00
72_L 76_L 1.494 1.00
440_I 448_I 1.494 1.00
381_H 384_D 1.488 1.00
9_A 25_N 1.481 1.00
274_R 316_A 1.47 1.00
268_V 309_L 1.47 1.00
9_A 27_T 1.469 1.00
264_T 287_C 1.465 1.00
209_R 230_S 1.465 1.00
129_M 161_M 1.46 1.00
13_K 50_V 1.459 1.00
353_F 364_I 1.454 1.00
269_R 285_S 1.453 1.00
214_R 226_S 1.425 1.00
270_N 317_G 1.418 1.00
271_V 315_R 1.418 1.00
288_R 461_V 1.402 0.99
11_I 50_V 1.396 0.99
192_R 213_D 1.394 0.99
357_S 360_Q 1.392 0.99
26_L 216_T 1.392 0.99
121_E 124_V 1.392 0.99
356_F 360_Q 1.366 0.99
28_V 34_H 1.363 0.99
52_S 84_I 1.362 0.99
182_D 210_R 1.362 0.99
388_T 391_N 1.358 0.99
390_E 403_V 1.356 0.99
291_I 452_M 1.351 0.99
478_R 490_I 1.349 0.99
190_Q 194_E 1.347 0.99
286_V 430_V 1.345 0.99
147_S 150_H 1.337 0.99
343_I 433_F 1.334 0.99
202_S 208_I 1.328 0.99
91_V 143_V 1.328 0.99
54_I 86_Y 1.325 0.99
186_L 190_Q 1.325 0.99
128_M 132_R 1.319 0.99
279_V 282_I 1.316 0.99
497_M 501_E 1.316 0.99
268_V 320_I 1.313 0.99
503_M 506_A 1.313 0.99
13_K 46_T 1.312 0.99
64_I 166_V 1.303 0.99
358_I 418_V 1.285 0.99
190_Q 193_K 1.276 0.99
322_L 327_I 1.272 0.99
363_A 385_E 1.265 0.99
102_Y 126_A 1.262 0.99
390_E 394_E 1.259 0.99
6_I 64_I 1.257 0.99
359_A 403_V 1.253 0.99
493_N 497_M 1.252 0.99
452_M 462_I 1.243 0.98
405_Q 409_E 1.241 0.98
290_E 477_D 1.24 0.98
189_N 192_R 1.237 0.98
4_P 29_Y 1.23 0.98
273_S 313_D 1.223 0.98
14_S 59_K 1.222 0.98
63_T 68_S 1.221 0.98
406_N 409_E 1.21 0.98
433_F 452_M 1.193 0.98
340_M 430_V 1.185 0.98
271_V 308_C 1.183 0.98
98_L 123_R 1.179 0.98
387_R 391_N 1.177 0.98
50_V 62_I 1.171 0.98
322_L 430_V 1.16 0.97
48_M 84_I 1.153 0.97
491_L 505_W 1.152 0.97
353_F 356_F 1.151 0.97
281_D 486_R 1.147 0.97
361_N 422_K 1.144 0.97
98_L 126_A 1.136 0.97
130_L 139_L 1.135 0.97
123_R 127_A 1.133 0.97
32_E 213_D 1.126 0.97
15_F 46_T 1.123 0.97
50_V 57_P 1.12 0.96
92_I 103_I 1.115 0.96
48_M 168_I 1.114 0.96
146_L 154_L 1.114 0.96
284_F 305_L 1.114 0.96
64_I 82_I 1.111 0.96
386_Q 390_E 1.111 0.96
352_F 407_I 1.109 0.96
294_F 480_A 1.106 0.96
341_A 428_P 1.104 0.96
133_V 157_A 1.104 0.96
15_F 20_A 1.103 0.96
264_T 288_R 1.102 0.96
498_S 501_E 1.097 0.96
151_K 346_S 1.096 0.96
102_Y 122_M 1.093 0.96
182_D 186_L 1.093 0.96
21_L 24_V 1.091 0.96
239_R 245_E 1.088 0.96
23_S 222_S 1.086 0.96
292_L 463_L 1.085 0.96
8_M 62_I 1.082 0.96
274_R 277_K 1.08 0.95
12_G 22_K 1.078 0.95
479_I 497_M 1.078 0.95
127_A 139_L 1.077 0.95
384_D 387_R 1.076 0.95
67_I 76_L 1.074 0.95
93_D 151_K 1.073 0.95
212_C 215_Y 1.07 0.95
76_L 79_Q 1.067 0.95
11_I 57_P 1.066 0.95
265_V 323_N 1.062 0.95
35_A 208_I 1.061 0.95
272_T 280_R 1.061 0.95
13_K 55_H 1.06 0.95
265_V 461_V 1.059 0.95
131_L 136_K 1.054 0.95
83_G 164_A 1.052 0.95
191_L 196_T 1.051 0.94
30_P 197_A 1.048 0.94
233_S 236_D 1.045 0.94
6_I 51_L 1.044 0.94
427_C 458_D 1.044 0.94
45_S 49_K 1.037 0.94
14_S 58_T 1.035 0.94
264_T 321_R 1.035 0.94
279_V 308_C 1.032 0.94
143_V 154_L 1.031 0.94
236_D 240_L 1.024 0.93
128_M 131_L 1.02 0.93
321_R 326_D 1.02 0.93
308_C 320_I 1.015 0.93
237_I 241_M 1.015 0.93
455_L 460_K 1.013 0.93
294_F 305_L 1.012 0.93
185_F 210_R 1.012 0.93
393_R 398_L 1.008 0.93
496_D 501_E 1.002 0.92
163_D 194_E 1.001 0.92
295_A 472_I 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4finA20.90781000.2Contact Map0.757
3g5uA20.96081000.216Contact Map0.636
4f4cA10.96081000.219Contact Map0.71
1yqtA10.90591000.264Contact Map0.65
2iw3A20.87841000.273Contact Map0.726
3bk7A10.90591000.277Contact Map0.63
3ozxA20.89611000.278Contact Map0.673
3j16B10.92161000.295Contact Map0.476
3ux8A10.93141000.298Contact Map0.585
2vf7A30.9511000.408Contact Map0.559

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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