GREMLIN.BAKERLAB.org
Powered by OPENSEQ.org
AIDB - Putative acyl-CoA dehydrogenase AidB
UniProt: P33224 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11811
Length: 541 (515)
Sequences: 670
Seq/Len: 1.30

AIDB
Paralog alert: 0.26 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
236_S 280_L 5.29 1.00
415_Y 418_M 3.422 1.00
409_S 412_P 2.977 1.00
19_N 48_Q 2.909 1.00
286_E 289_R 2.893 1.00
240_V 278_G 2.834 1.00
73_D 77_R 2.648 1.00
191_S 326_V 2.559 1.00
263_N 417_E 2.52 1.00
22_L 44_A 2.479 1.00
227_V 273_F 2.435 1.00
463_F 499_L 2.324 0.99
313_A 393_V 2.319 0.99
303_A 381_A 2.272 0.99
325_H 330_P 2.22 0.99
201_E 211_V 2.179 0.99
183_G 217_F 2.17 0.99
330_P 333_Q 2.139 0.98
13_I 323_Q 2.135 0.98
183_G 273_F 2.06 0.98
230_Q 235_L 2.04 0.98
304_L 355_L 2.016 0.97
466_A 492_L 2.001 0.97
30_A 356_F 1.928 0.96
407_E 412_P 1.88 0.96
233_G 284_E 1.867 0.96
21_Y 40_S 1.859 0.95
310_M 392_F 1.753 0.93
32_T 40_S 1.737 0.93
203_L 209_R 1.736 0.93
36_A 116_A 1.721 0.92
193_V 196_N 1.714 0.92
354_L 381_A 1.712 0.92
329_N 479_E 1.699 0.92
449_L 489_L 1.692 0.91
193_V 288_I 1.674 0.91
217_F 271_V 1.67 0.91
5_T 8_V 1.659 0.90
253_R 274_Q 1.653 0.90
57_E 61_L 1.635 0.89
240_V 276_A 1.618 0.89
317_A 399_V 1.608 0.88
19_N 47_G 1.587 0.87
84_F 88_W 1.579 0.87
90_L 93_Q 1.578 0.87
357_R 361_A 1.562 0.86
312_R 316_L 1.549 0.86
88_W 179_L 1.547 0.86
357_R 370_E 1.544 0.85
252_I 276_A 1.54 0.85
236_S 278_G 1.539 0.85
38_W 112_G 1.527 0.85
70_L 83_R 1.525 0.85
329_N 334_Q 1.522 0.84
50_L 95_L 1.516 0.84
93_Q 97_T 1.515 0.84
60_R 64_V 1.512 0.84
306_S 389_G 1.51 0.84
130_G 265_S 1.503 0.83
211_V 275_D 1.499 0.83
350_G 494_C 1.497 0.83
34_E 360_R 1.496 0.83
19_N 22_L 1.496 0.83
156_W 178_L 1.486 0.82
36_A 39_D 1.479 0.82
39_D 116_A 1.461 0.81
6_H 197_T 1.456 0.81
184_M 291_I 1.454 0.80
346_L 495_G 1.452 0.80
321_A 399_V 1.44 0.80
463_F 467_V 1.438 0.79
209_R 275_D 1.429 0.79
269_C 292_L 1.428 0.79
57_E 60_R 1.418 0.78
224_A 420_V 1.412 0.78
95_L 131_S 1.41 0.78
449_L 453_F 1.407 0.77
105_W 114_F 1.404 0.77
182_M 294_M 1.401 0.77
68_E 83_R 1.397 0.77
244_L 248_Q 1.392 0.76
179_L 222_S 1.384 0.76
42_F 120_R 1.373 0.75
319_Y 323_Q 1.373 0.75
357_R 452_A 1.368 0.74
171_P 174_Q 1.345 0.73
251_A 276_A 1.328 0.71
280_L 284_E 1.324 0.71
172_G 178_L 1.324 0.71
271_V 406_C 1.321 0.71
207_S 277_I 1.317 0.70
451_E 454_V 1.31 0.70
283_L 286_E 1.296 0.69
463_F 495_G 1.294 0.68
52_T 55_S 1.287 0.68
458_G 464_D 1.284 0.68
405_Y 420_V 1.282 0.67
303_A 358_L 1.28 0.67
122_M 304_L 1.279 0.67
261_L 405_Y 1.263 0.66
334_Q 430_I 1.261 0.66
66_P 264_R 1.26 0.66
210_L 278_G 1.259 0.65
106_E 163_D 1.258 0.65
380_A 490_F 1.256 0.65
314_F 392_F 1.251 0.65
394_A 422_S 1.248 0.64
59_G 127_V 1.244 0.64
55_S 58_L 1.241 0.64
49_Q 54_E 1.239 0.64
241_P 250_N 1.235 0.63
11_Q 14_P 1.229 0.63
58_L 94_A 1.226 0.62
511_C 515_L 1.222 0.62
341_L 344_M 1.222 0.62
463_F 497_Q 1.219 0.62
95_L 124_H 1.218 0.62
38_W 110_R 1.212 0.61
183_G 227_V 1.211 0.61
17_N 127_V 1.21 0.61
329_N 465_R 1.207 0.61
153_F 157_T 1.206 0.61
96_C 177_G 1.205 0.60
454_V 471_Q 1.201 0.60
58_L 87_A 1.2 0.60
139_F 180_I 1.197 0.60
353_A 501_Y 1.193 0.59
151_A 156_W 1.19 0.59
259_D 264_R 1.188 0.59
42_F 45_S 1.184 0.58
397_M 423_I 1.184 0.58
134_P 437_R 1.18 0.58
420_V 431_M 1.176 0.58
510_W 514_M 1.176 0.58
308_A 330_P 1.175 0.58
65_N 68_E 1.174 0.57
449_L 492_L 1.171 0.57
45_S 98_N 1.17 0.57
169_L 243_F 1.163 0.56
29_E 33_R 1.162 0.56
313_A 396_A 1.162 0.56
61_L 83_R 1.162 0.56
226_L 235_L 1.158 0.56
377_F 493_G 1.157 0.56
35_G 38_W 1.154 0.55
164_R 176_R 1.153 0.55
63_N 85_H 1.15 0.55
370_E 376_L 1.149 0.55
49_Q 98_N 1.148 0.55
277_I 280_L 1.147 0.55
46_I 124_H 1.141 0.54
22_L 31_V 1.138 0.54
146_L 157_T 1.138 0.54
108_D 206_G 1.135 0.54
193_V 291_I 1.132 0.53
452_A 456_V 1.13 0.53
355_L 435_V 1.121 0.52
121_F 289_R 1.12 0.52
43_L 119_A 1.117 0.52
368_A 372_L 1.117 0.52
288_I 292_L 1.105 0.51
220_P 337_M 1.103 0.50
114_F 363_D 1.101 0.50
134_P 424_W 1.099 0.50
336_L 429_N 1.098 0.50
134_P 137_M 1.098 0.50
24_D 122_M 1.098 0.50
15_L 18_S 1.096 0.50
12_P 511_C 1.095 0.50
55_S 94_A 1.092 0.49
159_P 178_L 1.091 0.49
371_A 442_Q 1.091 0.49
322_H 332_I 1.09 0.49
342_S 498_M 1.087 0.49
134_P 193_V 1.087 0.49
435_V 486_T 1.086 0.49
450_S 471_Q 1.081 0.48
263_N 266_N 1.078 0.48
24_D 264_R 1.077 0.48
347_Q 388_R 1.076 0.48
133_C 424_W 1.075 0.48
210_L 354_L 1.068 0.47
217_F 252_I 1.066 0.47
473_Q 481_L 1.066 0.47
288_I 291_I 1.063 0.46
376_L 439_L 1.063 0.46
183_G 431_M 1.062 0.46
329_N 469_R 1.061 0.46
104_A 139_F 1.055 0.46
180_I 224_A 1.054 0.46
184_M 193_V 1.054 0.46
403_I 409_S 1.053 0.45
5_T 197_T 1.052 0.45
390_M 415_Y 1.05 0.45
187_K 213_H 1.049 0.45
326_V 430_I 1.049 0.45
307_H 348_L 1.044 0.45
95_L 135_I 1.042 0.44
193_V 219_V 1.042 0.44
207_S 280_L 1.041 0.44
321_A 341_L 1.04 0.44
225_H 252_I 1.034 0.44
43_L 371_A 1.031 0.43
447_D 472_Q 1.027 0.43
208_Y 231_T 1.026 0.43
278_G 310_M 1.024 0.43
275_D 516_D 1.023 0.43
50_L 55_S 1.022 0.42
308_A 329_N 1.017 0.42
199_R 211_V 1.016 0.42
353_A 498_M 1.015 0.42
203_L 207_S 1.015 0.42
390_M 394_A 1.014 0.42
227_V 322_H 1.013 0.42
415_Y 419_P 1.012 0.41
17_N 53_A 1.009 0.41
306_S 386_C 1.008 0.41
136_T 418_M 1.007 0.41
244_L 277_I 1.005 0.41
252_I 479_E 1.003 0.41
18_S 23_S 1.002 0.40
182_M 337_M 1.002 0.40
344_M 396_A 1.001 0.40
239_F 281_L 1.001 0.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3djlA111000.366Contact Map0.656
2uxwA10.92051000.631Contact Map0.536
3owaA40.9151000.67Contact Map0.6
2z1qA20.90941000.671Contact Map0.603
4ktoA40.72831000.698Contact Map0.571
2jifA40.71721000.7Contact Map0.609
1ivhA40.6951000.7Contact Map0.588
1rx0A40.70061000.701Contact Map0.585
3nf4A20.69131000.702Contact Map0.562
1bucA20.67281000.703Contact Map0.579

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0357 seconds.