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ADIY - HTH-type transcriptional regulator AdiY
UniProt: P33234 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11966
Length: 253 (241)
Sequences: 11975
Seq/Len: 49.69

ADIY
Paralog alert: 0.79 [within 20: 0.28] - ratio of genomes with paralogs
Cluster includes: ADIY APPY ARAC CHBR ENVY EUTR FEAR GADW GADX MARA MELR RHAR RHAS SOXS YBCM YDEO YDIP YEAM YIDL YIJO YKGD YPDC YQHC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
199_M 236_Y 3.566 1.00
154_I 158_D 3.281 1.00
211_K 219_S 3.202 1.00
166_S 176_P 3.173 1.00
156_E 197_C 3.152 1.00
158_D 161_K 3.052 1.00
201_Y 204_N 3.01 1.00
203_V 236_Y 2.974 1.00
188_T 196_T 2.919 1.00
232_F 243_Y 2.837 1.00
202_A 228_F 2.542 1.00
196_T 235_F 2.395 1.00
205_E 219_S 2.335 1.00
183_L 193_I 2.312 1.00
164_N 167_M 2.306 1.00
155_I 194_I 2.289 1.00
199_M 235_F 2.164 1.00
19_W 27_P 2.093 1.00
206_L 213_I 2.07 1.00
155_I 197_C 2.038 1.00
205_E 220_C 2.034 1.00
212_N 215_Q 2.033 1.00
205_E 211_K 2.031 1.00
211_K 215_Q 1.992 1.00
159_I 197_C 1.932 1.00
154_I 171_C 1.917 1.00
121_L 124_T 1.905 1.00
201_Y 205_E 1.887 1.00
19_W 29_S 1.847 1.00
191_S 195_T 1.832 1.00
31_K 34_H 1.81 1.00
154_I 163_W 1.783 1.00
238_M 246_Q 1.774 1.00
165_L 180_K 1.754 1.00
174_L 179_L 1.746 1.00
241_L 245_S 1.741 1.00
153_Q 157_S 1.734 1.00
151_V 179_L 1.717 1.00
21_R 27_P 1.712 1.00
14_T 54_L 1.66 1.00
151_V 172_L 1.648 1.00
17_D 29_S 1.625 1.00
202_A 220_C 1.621 1.00
203_V 243_Y 1.614 1.00
168_V 190_Y 1.604 1.00
23_N 42_N 1.588 1.00
215_Q 219_S 1.557 1.00
214_S 225_T 1.556 1.00
178_L 182_K 1.55 1.00
156_E 193_I 1.547 1.00
227_Y 231_V 1.541 1.00
229_I 239_T 1.531 1.00
15_E 52_N 1.523 1.00
151_V 168_V 1.514 1.00
215_Q 218_Q 1.479 1.00
209_D 244_V 1.477 1.00
39_N 42_N 1.475 1.00
176_P 180_K 1.466 1.00
178_L 181_K 1.456 1.00
161_K 167_M 1.449 1.00
179_L 190_Y 1.43 1.00
21_R 46_D 1.429 1.00
224_S 230_S 1.42 1.00
166_S 170_S 1.418 1.00
229_I 241_L 1.417 1.00
17_D 31_K 1.415 1.00
120_A 127_S 1.41 1.00
174_L 178_L 1.408 1.00
214_S 218_Q 1.407 0.99
159_I 201_Y 1.397 0.99
190_Y 194_I 1.391 0.99
216_V 220_C 1.391 0.99
9_C 45_I 1.381 0.99
225_T 229_I 1.373 0.99
238_M 242_H 1.363 0.99
204_N 208_M 1.329 0.99
226_S 229_I 1.329 0.99
201_Y 220_C 1.328 0.99
188_T 192_Q 1.306 0.99
222_Y 231_V 1.286 0.99
154_I 168_V 1.282 0.99
152_Y 156_E 1.282 0.99
213_I 216_V 1.28 0.99
197_C 201_Y 1.279 0.99
231_V 234_D 1.279 0.99
165_L 190_Y 1.277 0.99
168_V 171_C 1.273 0.99
177_S 181_K 1.252 0.99
167_M 171_C 1.246 0.98
127_S 131_D 1.243 0.98
189_S 192_Q 1.241 0.98
239_T 242_H 1.23 0.98
196_T 200_R 1.191 0.98
34_H 89_T 1.19 0.98
98_F 102_A 1.183 0.98
169_A 176_P 1.176 0.98
180_K 190_Y 1.164 0.97
230_S 234_D 1.156 0.97
124_T 128_R 1.155 0.97
175_S 178_L 1.155 0.97
13_L 16_K 1.155 0.97
147_V 172_L 1.151 0.97
198_R 220_C 1.148 0.97
197_C 200_R 1.136 0.97
15_E 32_A 1.133 0.97
145_N 186_E 1.114 0.96
147_V 174_L 1.113 0.96
211_K 216_V 1.108 0.96
13_L 18_V 1.088 0.96
30_L 36_A 1.079 0.95
8_P 40_C 1.073 0.95
167_M 170_S 1.071 0.95
99_R 102_A 1.064 0.95
120_A 124_T 1.063 0.95
159_I 194_I 1.058 0.95
209_D 216_V 1.056 0.95
216_V 244_V 1.055 0.95
195_T 231_V 1.05 0.94
117_R 121_L 1.05 0.94
180_K 189_S 1.045 0.94
236_Y 243_Y 1.035 0.94
229_I 233_K 1.028 0.94
163_W 168_V 1.015 0.93
117_R 124_T 1.013 0.93
160_H 219_S 1.011 0.93
228_F 240_P 1.01 0.93
203_V 232_F 1.009 0.93
160_H 201_Y 1.009 0.93
224_S 227_Y 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3gbgA10.95651000.18Contact Map0.639
3oouA10.42291000.385Contact Map0.774
3oioA10.44271000.388Contact Map0.783
1bl0A10.466499.90.391Contact Map0.721
3mn2A20.41599.90.391Contact Map0.744
3mklA20.450699.90.392Contact Map0.79
2k9sA10.41599.90.4Contact Map0.561
3w6vA10.565299.90.405Contact Map0.772
3lsgA50.399299.90.408Contact Map0.87
1d5yA40.434899.90.418Contact Map0.682

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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