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YEHW - Putative osmoprotectant uptake system permease protein YehW
UniProt: P33359 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12009
Length: 243 (202)
Sequences: 8131
Seq/Len: 40.25

YEHW
Paralog alert: 0.86 [within 20: 0.44] - ratio of genomes with paralogs
Cluster includes: ARTM ARTQ GLNP GLTJ GLTK HISM HISQ METI PHNE SSUC TAUC YECS YEHW
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
156_G 160_R 3.485 1.00
154_S 157_Q 3.217 1.00
148_A 162_V 2.755 1.00
63_F 122_I 2.547 1.00
84_R 138_G 2.506 1.00
149_K 158_R 2.477 1.00
209_N 212_Y 2.224 1.00
67_I 122_I 2.125 1.00
51_L 55_W 2.116 1.00
148_A 153_M 2.115 1.00
136_G 170_V 2.07 1.00
106_A 119_I 2.07 1.00
110_I 119_I 2.004 1.00
233_R 237_A 1.993 1.00
65_V 175_V 1.992 1.00
157_Q 161_K 1.916 1.00
233_R 236_Q 1.859 1.00
53_H 56_L 1.852 1.00
72_G 133_T 1.846 1.00
76_T 137_L 1.831 1.00
201_I 216_G 1.814 1.00
64_A 125_G 1.771 1.00
49_L 200_P 1.762 1.00
67_I 70_G 1.759 1.00
55_W 59_I 1.744 1.00
229_R 233_R 1.718 1.00
72_G 76_T 1.702 1.00
133_T 171_I 1.677 1.00
61_S 179_V 1.674 1.00
67_I 126_V 1.67 1.00
145_T 158_R 1.653 1.00
68_G 130_L 1.652 1.00
66_I 70_G 1.646 1.00
129_V 178_S 1.64 1.00
81_A 85_P 1.638 1.00
47_A 51_L 1.623 1.00
155_R 158_R 1.594 1.00
137_L 163_E 1.525 1.00
230_L 234_L 1.503 1.00
53_H 186_A 1.496 1.00
49_L 52_A 1.491 1.00
237_A 240_Q 1.491 1.00
145_T 163_E 1.425 1.00
115_Q 119_I 1.415 1.00
59_I 118_I 1.405 0.99
75_V 130_L 1.396 0.99
183_I 227_A 1.385 0.99
78_P 83_F 1.365 0.99
68_G 129_V 1.359 0.99
77_R 155_R 1.357 0.99
136_G 174_G 1.346 0.99
82_E 86_L 1.339 0.99
64_A 122_I 1.337 0.99
148_A 158_R 1.334 0.99
126_V 130_L 1.333 0.99
75_V 134_L 1.323 0.99
204_G 212_Y 1.308 0.99
52_A 56_L 1.296 0.99
78_P 81_A 1.296 0.99
81_A 84_R 1.263 0.99
167_A 171_I 1.262 0.99
84_R 88_E 1.259 0.99
74_A 83_F 1.255 0.99
72_G 137_L 1.252 0.99
65_V 69_T 1.249 0.99
200_P 216_G 1.246 0.98
202_I 205_L 1.236 0.98
71_A 126_V 1.223 0.98
60_S 121_L 1.206 0.98
114_L 118_I 1.177 0.98
55_W 114_L 1.163 0.97
49_L 53_H 1.155 0.97
134_L 138_G 1.15 0.97
78_P 82_E 1.14 0.97
147_V 152_G 1.137 0.97
77_R 163_E 1.134 0.97
145_T 149_K 1.133 0.97
50_A 223_A 1.125 0.97
187_T 220_V 1.122 0.97
140_I 166_L 1.12 0.96
71_A 130_L 1.117 0.96
147_V 151_M 1.117 0.96
58_G 62_L 1.116 0.96
117_A 189_A 1.115 0.96
132_A 174_G 1.113 0.96
202_I 206_S 1.113 0.96
50_A 197_L 1.111 0.96
176_R 228_D 1.102 0.96
56_L 114_L 1.102 0.96
84_R 134_L 1.101 0.96
124_Y 185_T 1.094 0.96
153_M 157_Q 1.088 0.96
68_G 72_G 1.077 0.95
176_R 235_V 1.076 0.95
153_M 158_R 1.071 0.95
61_S 175_V 1.069 0.95
91_A 130_L 1.065 0.95
74_A 78_P 1.06 0.95
142_A 146_E 1.056 0.95
53_H 57_V 1.054 0.95
107_V 111_G 1.048 0.94
69_T 171_I 1.04 0.94
157_Q 160_R 1.04 0.94
142_A 149_K 1.038 0.94
52_A 195_S 1.034 0.94
144_V 147_V 1.033 0.94
106_A 110_I 1.03 0.94
70_G 74_A 1.03 0.94
172_L 238_L 1.028 0.94
128_P 181_I 1.024 0.93
225_I 229_R 1.023 0.93
143_S 146_E 1.022 0.93
146_E 149_K 1.017 0.93
82_E 85_P 1.009 0.93
179_V 227_A 1.006 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3d31C20.995999.90.573Contact Map0.641
2onkC40.995999.90.574Contact Map0.674
3tuiA40.839599.90.587Contact Map0.8
3rlfF10.983599.90.615Contact Map0.688
3rlfG10.995999.80.648Contact Map0.576
4lz6A10.9342100.954Contact Map0.331
3w4tA10.92188.20.956Contact Map0.27
3tdsE50.40337.50.957Contact Map0.412
3mktA20.92184.50.961Contact Map0.23
2kv5A10.13583.90.962Contact Map0.375

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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