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BGLX - Periplasmic beta-glucosidase
UniProt: P33363 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12013
Length: 765 (727)
Sequences: 2691
Seq/Len: 3.70

BGLX
Paralog alert: 0.31 [within 20: 0.07] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
682_E 715_P 4.873 1.00
674_Q 718_T 4.317 1.00
650_T 678_T 4.197 1.00
682_E 714_K 4.192 1.00
392_R 583_D 4.135 1.00
131_N 393_E 4.031 1.00
676_T 718_T 3.896 1.00
137_T 389_E 3.867 1.00
39_T 347_R 3.84 1.00
655_D 674_Q 3.537 1.00
136_K 190_E 3.478 1.00
389_E 393_E 3.422 1.00
649_T 679_G 3.375 1.00
551_N 569_E 3.185 1.00
40_E 44_K 3.131 1.00
449_A 588_D 3.131 1.00
509_V 535_I 3.117 1.00
128_S 596_P 3.071 1.00
233_F 277_Q 3.025 1.00
141_V 386_E 2.995 1.00
653_V 752_T 2.987 1.00
590_N 683_G 2.956 1.00
707_G 723_F 2.955 1.00
388_R 583_D 2.897 1.00
212_A 227_M 2.893 1.00
48_D 329_P 2.822 1.00
442_V 508_V 2.79 1.00
312_K 341_E 2.78 1.00
446_I 586_F 2.703 1.00
49_E 101_R 2.687 1.00
673_V 687_V 2.674 1.00
395_L 584_V 2.655 1.00
241_K 245_D 2.643 1.00
138_V 390_V 2.614 1.00
684_A 712_T 2.592 1.00
590_N 647_S 2.545 1.00
689_M 723_F 2.531 1.00
684_A 710_K 2.528 1.00
228_S 231_R 2.522 1.00
207_V 248_S 2.439 1.00
672_S 720_T 2.421 1.00
204_M 249_G 2.409 1.00
392_R 589_Y 2.38 1.00
161_V 235_D 2.371 1.00
748_V 762_F 2.37 1.00
47_V 332_I 2.35 1.00
182_S 242_A 2.329 1.00
275_R 344_D 2.303 1.00
693_D 746_F 2.302 1.00
714_K 717_E 2.293 1.00
584_V 589_Y 2.272 1.00
446_I 456_V 2.255 1.00
316_N 348_H 2.245 1.00
459_A 494_E 2.245 1.00
507_A 538_L 2.217 1.00
450_V 586_F 2.214 1.00
50_K 343_D 2.185 1.00
54_L 342_L 2.18 1.00
328_L 337_V 2.169 1.00
206_S 250_A 2.155 1.00
253_V 264_T 2.143 1.00
267_S 272_D 2.117 1.00
506_V 548_V 2.114 1.00
393_E 684_A 2.101 1.00
649_T 683_G 2.1 1.00
682_E 712_T 2.093 1.00
254_A 263_A 2.092 1.00
412_T 455_K 2.055 1.00
189_V 243_G 2.05 1.00
726_D 729_A 2.042 1.00
272_D 276_D 2.033 1.00
391_A 580_A 2.009 1.00
443_L 447_K 2.001 1.00
656_V 758_K 1.996 1.00
51_I 329_P 1.98 1.00
576_E 579_N 1.98 1.00
388_R 579_N 1.975 1.00
752_T 756_R 1.969 1.00
573_A 577_G 1.968 1.00
457_L 502_S 1.965 1.00
547_L 564_A 1.96 1.00
268_W 273_V 1.955 1.00
409_K 588_D 1.936 1.00
388_R 392_R 1.929 1.00
132_L 709_E 1.927 1.00
505_V 538_L 1.924 1.00
498_T 502_S 1.92 1.00
132_L 183_T 1.915 1.00
674_Q 720_T 1.886 1.00
713_L 719_Q 1.856 1.00
670_T 722_S 1.855 1.00
652_T 676_T 1.814 0.99
229_P 233_F 1.814 0.99
445_G 582_A 1.804 0.99
120_F 141_V 1.802 0.99
38_V 347_R 1.8 0.99
703_K 749_F 1.793 0.99
407_L 504_V 1.788 0.99
312_K 338_T 1.786 0.99
713_L 717_E 1.786 0.99
694_V 747_N 1.783 0.99
700_R 704_Q 1.771 0.99
267_S 271_K 1.769 0.99
560_E 567_I 1.768 0.99
341_E 344_D 1.76 0.99
653_V 685_T 1.752 0.99
268_W 272_D 1.752 0.99
682_E 713_L 1.724 0.99
329_P 333_K 1.708 0.99
125_G 394_S 1.704 0.99
697_S 732_F 1.699 0.99
654_S 674_Q 1.693 0.99
583_D 588_D 1.687 0.99
388_R 576_E 1.687 0.99
183_T 242_A 1.681 0.99
47_V 339_M 1.68 0.99
651_F 683_G 1.677 0.99
592_S 684_A 1.666 0.99
537_A 540_A 1.66 0.99
497_Q 500_K 1.654 0.99
384_R 576_E 1.644 0.99
46_T 101_R 1.637 0.99
536_A 563_Q 1.636 0.99
283_I 352_V 1.632 0.99
538_L 545_L 1.628 0.99
633_D 755_A 1.624 0.98
594_K 685_T 1.622 0.98
652_T 678_T 1.619 0.98
51_I 342_L 1.617 0.98
159_V 207_V 1.616 0.98
413_I 504_V 1.615 0.98
207_V 251_V 1.6 0.98
526_T 556_A 1.6 0.98
415_V 443_L 1.596 0.98
448_N 579_N 1.593 0.98
415_V 446_I 1.583 0.98
509_V 549_L 1.577 0.98
35_D 351_N 1.576 0.98
118_T 387_A 1.576 0.98
47_V 342_L 1.576 0.98
421_D 443_L 1.575 0.98
338_T 341_E 1.575 0.98
549_L 569_E 1.573 0.98
539_K 564_A 1.565 0.98
441_T 444_T 1.564 0.98
745_K 763_E 1.559 0.98
734_N 740_D 1.553 0.98
249_G 355_D 1.545 0.98
302_D 305_D 1.545 0.98
691_L 706_K 1.537 0.98
570_T 573_A 1.534 0.98
561_D 640_Y 1.529 0.98
271_K 276_D 1.525 0.97
45_M 53_Q 1.525 0.97
443_L 458_Y 1.525 0.97
416_V 507_A 1.516 0.97
42_L 347_R 1.516 0.97
442_V 581_I 1.516 0.97
94_D 98_E 1.503 0.97
685_T 752_T 1.502 0.97
686_V 710_K 1.501 0.97
446_I 585_L 1.494 0.97
697_S 742_E 1.491 0.97
393_E 710_K 1.49 0.97
274_L 284_T 1.488 0.97
332_I 342_L 1.484 0.97
692_Q 747_N 1.478 0.97
416_V 505_V 1.477 0.97
497_Q 501_Q 1.474 0.97
641_P 644_Y 1.471 0.97
670_T 724_P 1.467 0.97
404_T 565_D 1.461 0.97
647_S 683_G 1.456 0.96
412_T 457_L 1.452 0.96
54_L 311_L 1.451 0.96
183_T 186_K 1.448 0.96
641_P 753_D 1.448 0.96
492_I 496_V 1.443 0.96
440_V 579_N 1.441 0.96
440_V 445_G 1.44 0.96
496_V 537_A 1.432 0.96
378_A 385_K 1.429 0.96
136_K 140_R 1.428 0.96
48_D 333_K 1.425 0.96
404_T 566_A 1.422 0.96
343_D 346_A 1.419 0.96
253_V 290_A 1.417 0.96
332_I 338_T 1.415 0.96
211_A 269_L 1.414 0.96
389_E 392_R 1.414 0.96
244_L 248_S 1.414 0.96
311_L 345_A 1.413 0.96
745_K 761_E 1.413 0.96
329_P 332_I 1.41 0.95
129_S 390_V 1.408 0.95
135_V 184_M 1.407 0.95
601_R 637_G 1.398 0.95
244_L 251_V 1.398 0.95
312_K 337_V 1.394 0.95
38_V 42_L 1.392 0.95
691_L 748_V 1.382 0.95
508_V 581_I 1.378 0.95
725_I 730_L 1.376 0.95
204_M 352_V 1.374 0.95
539_K 565_D 1.373 0.95
579_N 583_D 1.371 0.94
182_S 186_K 1.368 0.94
559_K 563_Q 1.367 0.94
140_R 194_G 1.365 0.94
42_L 350_L 1.361 0.94
330_G 334_S 1.36 0.94
547_L 560_E 1.355 0.94
731_K 741_A 1.351 0.94
126_L 135_V 1.351 0.94
568_L 585_L 1.348 0.94
570_T 581_I 1.347 0.94
308_R 336_K 1.344 0.94
533_D 537_A 1.343 0.94
461_G 495_A 1.34 0.94
37_F 40_E 1.339 0.94
649_T 678_T 1.328 0.93
711_I 721_V 1.324 0.93
672_S 722_S 1.323 0.93
654_S 676_T 1.322 0.93
217_E 220_K 1.317 0.93
186_K 242_A 1.313 0.93
286_S 291_I 1.308 0.92
495_A 499_A 1.303 0.92
258_L 263_A 1.301 0.92
752_T 757_V 1.301 0.92
592_S 710_K 1.298 0.92
376_T 384_R 1.294 0.92
230_Q 234_N 1.294 0.92
548_V 570_T 1.289 0.92
261_T 266_D 1.289 0.92
747_N 759_K 1.285 0.92
505_V 545_L 1.285 0.92
345_A 348_H 1.282 0.91
396_V 571_W 1.281 0.91
692_Q 749_F 1.28 0.91
457_L 501_Q 1.28 0.91
339_M 343_D 1.278 0.91
134_A 386_E 1.276 0.91
544_P 565_D 1.275 0.91
507_A 535_I 1.269 0.91
263_A 266_D 1.268 0.91
751_G 754_S 1.266 0.91
492_I 537_A 1.265 0.91
193_Q 205_T 1.262 0.91
179_Y 707_G 1.262 0.91
401_R 565_D 1.259 0.90
402_L 565_D 1.257 0.90
37_F 354_Y 1.257 0.90
253_V 270_L 1.256 0.90
340_A 343_D 1.255 0.90
668_K 724_P 1.255 0.90
238_P 242_A 1.253 0.90
459_A 498_T 1.249 0.90
753_D 756_R 1.249 0.90
638_A 641_P 1.248 0.90
395_L 570_T 1.241 0.90
159_V 185_G 1.24 0.90
416_V 538_L 1.238 0.90
156_A 192_M 1.227 0.89
734_N 738_K 1.221 0.89
51_I 332_I 1.215 0.88
637_G 755_A 1.21 0.88
525_I 556_A 1.209 0.88
671_A 750_I 1.207 0.88
126_L 138_V 1.207 0.88
504_V 546_V 1.206 0.88
237_M 273_V 1.206 0.88
536_A 559_K 1.202 0.88
530_S 533_D 1.201 0.88
594_K 752_T 1.199 0.87
414_A 502_S 1.196 0.87
567_I 640_Y 1.195 0.87
45_M 102_L 1.193 0.87
46_T 49_E 1.192 0.87
594_K 653_V 1.189 0.87
286_S 315_I 1.188 0.87
671_A 689_M 1.188 0.87
132_L 187_T 1.188 0.87
387_A 391_A 1.183 0.86
46_T 102_L 1.18 0.86
354_Y 359_F 1.178 0.86
270_L 284_T 1.177 0.86
207_V 243_G 1.176 0.86
158_M 173_G 1.168 0.86
281_K 355_D 1.168 0.86
145_E 383_H 1.165 0.85
300_A 306_A 1.165 0.85
494_E 498_T 1.164 0.85
188_M 192_M 1.159 0.85
230_Q 698_M 1.158 0.85
457_L 498_T 1.156 0.85
561_D 567_I 1.153 0.84
127_A 596_P 1.145 0.84
407_L 546_V 1.145 0.84
656_V 750_I 1.14 0.84
141_V 383_H 1.139 0.84
413_I 450_V 1.139 0.84
659_S 670_T 1.133 0.83
39_T 42_L 1.133 0.83
533_D 536_A 1.124 0.82
304_E 330_G 1.122 0.82
449_A 583_D 1.119 0.82
700_R 732_F 1.117 0.82
741_A 764_L 1.115 0.82
212_A 232_L 1.104 0.81
154_T 192_M 1.101 0.81
288_H 319_M 1.101 0.81
308_R 331_L 1.1 0.80
731_K 739_Y 1.096 0.80
232_L 273_V 1.092 0.80
496_V 500_K 1.092 0.80
264_T 290_A 1.09 0.80
496_V 541_T 1.09 0.80
681_R 715_P 1.087 0.79
47_V 333_K 1.087 0.79
537_A 541_T 1.082 0.79
529_Q 533_D 1.082 0.79
725_I 748_V 1.08 0.79
541_T 544_P 1.08 0.79
412_T 503_D 1.078 0.79
189_V 248_S 1.077 0.79
308_R 312_K 1.076 0.78
440_V 578_G 1.073 0.78
532_R 536_A 1.071 0.78
275_R 348_H 1.07 0.78
233_F 273_V 1.066 0.78
317_M 349_V 1.066 0.78
404_T 504_V 1.066 0.78
594_K 686_V 1.065 0.77
42_L 346_A 1.064 0.77
136_K 187_T 1.063 0.77
549_L 557_L 1.061 0.77
241_K 278_W 1.06 0.77
411_A 504_V 1.059 0.77
136_K 194_G 1.058 0.77
311_L 328_L 1.055 0.76
673_V 720_T 1.054 0.76
38_V 351_N 1.053 0.76
41_L 45_M 1.051 0.76
594_K 754_S 1.046 0.76
137_T 140_R 1.045 0.76
693_D 744_G 1.043 0.75
330_G 333_K 1.041 0.75
509_V 547_L 1.04 0.75
143_A 192_M 1.035 0.75
251_V 274_L 1.033 0.74
271_K 313_S 1.032 0.74
238_P 241_K 1.032 0.74
332_I 337_V 1.03 0.74
742_E 746_F 1.029 0.74
304_E 334_S 1.027 0.74
689_M 750_I 1.024 0.73
170_A 597_M 1.024 0.73
505_V 543_K 1.021 0.73
416_V 495_A 1.021 0.73
711_I 719_Q 1.019 0.73
48_D 51_I 1.019 0.73
412_T 501_Q 1.018 0.73
696_A 742_E 1.015 0.72
301_A 305_D 1.015 0.72
228_S 735_Q 1.013 0.72
747_N 761_E 1.011 0.72
186_K 190_E 1.009 0.72
413_I 586_F 1.008 0.72
346_A 349_V 1.007 0.72
505_V 541_T 1.006 0.72
136_K 191_A 1.004 0.71
689_M 725_I 1.003 0.71
420_A 458_Y 1.003 0.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3u48A20.95291000.166Contact Map0.81
3abzA40.86541000.2Contact Map0.816
4i3gA20.90591000.201Contact Map0.788
2x41A10.86931000.229Contact Map0.811
3zyzA10.85491000.236Contact Map0.779
4iibA20.87581000.251Contact Map0.791
3rrxA10.8851000.327Contact Map0.743
1x38A10.73071000.397Contact Map0.78
3bmxA20.73331000.468Contact Map0.715
3sqlA20.63791000.538Contact Map0.51

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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