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NIKE - Nickel import ATP-binding protein NikE
UniProt: P33594 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12079
Length: 268 (247)
Sequences: 68159
Seq/Len: 275.95

NIKE
Paralog alert: 0.95 [within 20: 0.88] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
42_A 219_C 3.329 1.00
5_N 34_T 3.143 1.00
39_E 221_R 3.132 1.00
144_V 147_K 3 1.00
7_S 68_N 2.949 1.00
68_N 75_P 2.924 1.00
8_G 30_N 2.919 1.00
90_D 171_K 2.814 1.00
41_V 223_M 2.701 1.00
26_A 29_N 2.687 1.00
5_N 70_S 2.649 1.00
29_N 229_Q 2.489 1.00
36_K 39_E 2.443 1.00
221_R 233_T 2.38 1.00
136_K 141_D 2.359 1.00
130_R 169_E 2.277 1.00
10_S 30_N 2.27 1.00
72_R 171_K 2.26 1.00
11_H 57_L 2.245 1.00
6_I 9_L 2.214 1.00
12_H 26_A 2.213 1.00
234_Q 238_E 2.133 1.00
235_V 238_E 2.117 1.00
223_M 230_I 2.077 1.00
10_S 66_Q 2.055 1.00
132_S 145_L 2.043 1.00
10_S 26_A 2.028 1.00
135_L 145_L 2.007 1.00
108_V 152_L 1.937 1.00
109_R 146_D 1.923 1.00
196_K 200_Q 1.909 1.00
7_S 70_S 1.887 1.00
37_S 171_K 1.882 1.00
109_R 145_L 1.802 1.00
39_E 220_Q 1.759 1.00
8_G 32_S 1.756 1.00
109_R 132_S 1.735 1.00
13_Y 27_V 1.727 1.00
223_M 233_T 1.722 1.00
137_A 196_K 1.716 1.00
123_K 126_E 1.672 1.00
169_E 203_T 1.671 1.00
137_A 201_F 1.666 1.00
109_R 131_A 1.656 1.00
130_R 133_E 1.655 1.00
11_H 65_A 1.608 1.00
137_A 200_Q 1.607 1.00
133_E 137_A 1.579 1.00
128_L 132_S 1.56 1.00
147_K 151_Q 1.499 1.00
234_Q 239_K 1.465 1.00
12_H 65_A 1.455 1.00
70_S 75_P 1.446 1.00
198_Q 220_Q 1.438 1.00
96_Q 154_G 1.438 1.00
113_R 131_A 1.438 1.00
113_R 127_Q 1.418 1.00
7_S 34_T 1.404 0.99
55_A 208_I 1.398 0.99
109_R 128_L 1.398 0.99
11_H 62_E 1.386 0.99
72_R 90_D 1.385 0.99
109_R 113_R 1.368 0.99
129_A 133_E 1.362 0.99
209_T 215_V 1.348 0.99
28_L 57_L 1.34 0.99
6_I 58_L 1.326 0.99
33_L 223_M 1.323 0.99
13_Y 53_T 1.314 0.99
10_S 29_N 1.31 0.99
35_L 41_V 1.301 0.99
112_L 167_A 1.3 0.99
75_P 78_K 1.284 0.99
107_T 110_E 1.28 0.99
80_N 83_Q 1.276 0.99
57_L 64_P 1.27 0.99
3_L 72_R 1.262 0.99
41_V 233_T 1.256 0.99
195_K 198_Q 1.255 0.99
6_I 33_L 1.251 0.99
130_R 134_M 1.245 0.98
175_L 194_L 1.223 0.98
7_S 32_S 1.22 0.98
134_M 167_A 1.22 0.98
111_I 164_R 1.218 0.98
40_T 198_Q 1.218 0.98
9_L 64_P 1.17 0.97
55_A 174_I 1.166 0.97
108_V 160_V 1.162 0.97
58_L 206_L 1.157 0.97
40_T 205_C 1.155 0.97
169_E 201_F 1.153 0.97
132_S 136_K 1.153 0.97
198_Q 205_C 1.147 0.97
231_V 244_S 1.142 0.97
36_K 221_R 1.11 0.96
54_L 225_M 1.109 0.96
193_L 196_K 1.109 0.96
175_L 205_C 1.108 0.96
37_S 72_R 1.108 0.96
141_D 145_L 1.107 0.96
113_R 128_L 1.107 0.96
136_K 142_D 1.104 0.96
191_I 214_L 1.084 0.96
31_V 54_L 1.079 0.95
6_I 54_L 1.075 0.95
94_V 162_L 1.074 0.95
106_K 110_E 1.073 0.95
59_V 93_M 1.07 0.95
133_E 136_K 1.065 0.95
57_L 69_I 1.064 0.95
112_L 135_L 1.058 0.95
110_E 113_R 1.056 0.95
11_H 53_T 1.053 0.95
187_Q 214_L 1.05 0.94
244_S 247_G 1.048 0.94
56_R 62_E 1.044 0.94
138_V 163_A 1.043 0.94
126_E 129_A 1.042 0.94
173_L 205_C 1.038 0.94
152_L 160_V 1.031 0.94
74_E 83_Q 1.03 0.94
144_V 156_Q 1.03 0.94
41_V 221_R 1.026 0.94
8_G 66_Q 1.022 0.93
94_V 175_L 1.017 0.93
171_K 203_T 1.012 0.93
135_L 140_L 1.011 0.93
197_L 203_T 1.01 0.93
107_T 111_I 1.009 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tuiC40.9664100-0.012Contact Map0.884
1oxxK10.9552100-0.006Contact Map0.802
1g29120.95151000.001Contact Map0.9
2it1A20.93281000.002Contact Map0.87
2yyzA10.93281000.004Contact Map0.812
1v43A10.93281000.004Contact Map0.822
1z47A20.92911000.009Contact Map0.842
3rlfA20.93281000.01Contact Map0.845
3fvqA20.9441000.012Contact Map0.781
4fwiB10.97761000.019Contact Map0.731

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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