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CHPB - mRNA interferase ChpB
UniProt: P33647 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12096
Length: 116 (110)
Sequences: 1029
Seq/Len: 9.35

CHPB
Paralog alert: 0.39 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: CHPB MAZF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
33_L 107_A 3.169 1.00
17_F 32_A 2.875 1.00
14_L 96_I 2.523 1.00
64_S 81_N 2.506 1.00
100_A 103_V 2.47 1.00
49_A 78_V 2.441 1.00
9_R 108_L 2.304 1.00
15_V 32_A 2.077 1.00
24_E 91_R 1.994 1.00
11_D 98_L 1.86 1.00
17_F 84_R 1.815 1.00
78_V 107_A 1.793 1.00
10_G 104_V 1.771 1.00
35_L 49_A 1.735 1.00
20_A 26_Q 1.726 1.00
25_Q 79_L 1.699 1.00
32_A 86_M 1.617 1.00
33_L 99_A 1.617 1.00
20_A 84_R 1.59 1.00
13_V 92_L 1.58 1.00
106_E 110_R 1.567 1.00
49_A 80_V 1.541 1.00
87_D 90_A 1.53 1.00
53_Q 75_H 1.427 0.99
74_V 97_G 1.424 0.99
15_V 86_M 1.383 0.99
25_Q 30_R 1.377 0.99
73_D 97_G 1.332 0.99
16_G 28_A 1.312 0.99
7_F 34_V 1.288 0.99
12_I 72_G 1.263 0.98
11_D 95_R 1.242 0.98
103_V 106_E 1.211 0.98
14_L 94_K 1.19 0.97
83_V 111_L 1.16 0.97
8_E 38_Q 1.133 0.96
55_G 97_G 1.132 0.96
40_F 114_V 1.129 0.96
48_V 86_M 1.129 0.96
35_L 111_L 1.101 0.95
72_G 97_G 1.095 0.95
67_L 70_E 1.087 0.95
19_P 84_R 1.07 0.94
17_F 20_A 1.048 0.94
101_D 106_E 1.039 0.93
51_I 76_G 1.028 0.93
19_P 24_E 1.027 0.93
99_A 103_V 1.024 0.93
61_A 64_S 1.019 0.92
13_V 34_V 1.012 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1ub4A20.93971000.169Contact Map0.723
1m1fA20.93971000.173Contact Map0.863
4mdxA20.94831000.19Contact Map0.851
1ne8A10.94831000.193Contact Map0.803
2kmtA20.862199.30.596Contact Map0.524
3vubA10.8362990.643Contact Map0.682
2faoA20.87938.70.925Contact Map0.125
3nr7A20.35346.60.928Contact Map0.673
3k5wA10.34485.20.932Contact Map0.448
4e2qA160.37934.20.935Contact Map0

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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