GREMLIN.BAKERLAB.org
Powered by OPENSEQ.org
CCMA - Cytochrome c biogenesis ATP-binding export protein CcmA
UniProt: P33931 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12059
Length: 207 (202)
Sequences: 73530
Seq/Len: 364.01

CCMA
Paralog alert: 0.94 [within 20: 0.86] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
5_E 25_T 3.031 1.00
121_F 124_I 2.931 1.00
33_Q 195_K 2.892 1.00
59_E 66_P 2.848 1.00
7_R 59_E 2.791 1.00
8_E 21_G 2.782 1.00
17_T 20_S 2.781 1.00
114_A 119_A 2.774 1.00
30_E 197_R 2.689 1.00
77_N 148_T 2.615 1.00
5_E 61_L 2.609 1.00
27_N 30_E 2.534 1.00
32_V 199_I 2.342 1.00
12_E 17_T 2.267 1.00
10_L 17_T 2.207 1.00
10_L 57_A 2.206 1.00
10_L 21_G 2.196 1.00
6_A 9_L 2.16 1.00
93_A 129_L 2.142 1.00
11_C 48_L 2.122 1.00
7_R 61_L 2.061 1.00
108_Q 146_R 2.041 1.00
63_Q 148_T 2.015 1.00
110_L 122_E 1.901 1.00
113_L 122_E 1.819 1.00
146_R 179_G 1.789 1.00
94_L 122_E 1.777 1.00
94_L 110_L 1.731 1.00
94_L 123_D 1.689 1.00
28_A 148_T 1.679 1.00
13_R 18_L 1.669 1.00
115_Q 173_Q 1.655 1.00
111_E 115_Q 1.65 1.00
8_E 23_S 1.636 1.00
12_E 56_D 1.601 1.00
30_E 196_I 1.582 1.00
46_L 151_I 1.577 1.00
11_C 56_D 1.567 1.00
124_I 128_Q 1.558 1.00
94_L 98_H 1.542 1.00
46_L 184_T 1.528 1.00
26_L 32_V 1.507 1.00
83_H 131_A 1.491 1.00
94_L 109_C 1.476 1.00
11_C 53_S 1.471 1.00
106_T 110_L 1.434 1.00
119_A 122_E 1.416 1.00
108_Q 111_E 1.394 0.99
94_L 106_T 1.39 0.99
61_L 66_P 1.38 0.99
48_L 55_P 1.375 0.99
9_L 55_P 1.363 0.99
10_L 20_S 1.363 0.99
6_A 49_L 1.341 0.99
7_R 25_T 1.339 0.99
152_L 171_M 1.311 0.99
110_L 114_A 1.308 0.99
92_T 95_E 1.306 0.99
6_A 24_F 1.293 0.99
115_Q 177_Q 1.287 0.99
19_F 48_L 1.267 0.99
121_F 133_Q 1.244 0.98
96_N 141_R 1.242 0.98
110_L 119_A 1.232 0.98
24_F 199_I 1.229 0.98
107_A 111_E 1.218 0.98
93_A 137_V 1.216 0.98
47_R 53_S 1.206 0.98
63_Q 77_N 1.185 0.98
7_R 23_S 1.182 0.98
175_T 196_I 1.172 0.98
98_H 106_T 1.166 0.97
108_Q 112_A 1.158 0.97
3_M 63_Q 1.145 0.97
11_C 44_T 1.143 0.97
168_T 190_N 1.134 0.97
170_R 173_Q 1.133 0.97
116_A 140_A 1.127 0.97
148_T 179_G 1.121 0.97
6_A 45_L 1.117 0.96
50_T 80_W 1.104 0.96
98_H 109_C 1.094 0.96
31_W 175_T 1.083 0.96
174_H 179_G 1.08 0.95
31_W 181_V 1.073 0.95
97_L 144_L 1.062 0.95
112_A 140_A 1.052 0.95
185_T 191_V 1.05 0.94
164_V 190_N 1.046 0.94
164_V 187_Q 1.043 0.94
34_I 45_L 1.041 0.94
98_H 105_D 1.039 0.94
92_T 96_N 1.036 0.94
175_T 181_V 1.024 0.93
31_W 183_L 1.018 0.93
118_L 121_F 1.016 0.93
166_R 169_Q 1.013 0.93
125_P 128_Q 1.012 0.93
117_G 166_R 1.012 0.93
51_G 54_R 1.011 0.93
27_N 197_R 1.01 0.93
172_A 175_T 1.009 0.93
173_Q 177_Q 1.007 0.93
22_L 45_L 1.007 0.93
50_T 151_I 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2yyzA10.9952100-0.075Contact Map0.8
1v43A10.9952100-0.074Contact Map0.804
1g29121100-0.074Contact Map0.889
2it1A20.9952100-0.072Contact Map0.869
1oxxK11100-0.071Contact Map0.8
3rlfA20.9952100-0.07Contact Map0.86
1z47A20.9952100-0.07Contact Map0.811
3tuiC41100-0.07Contact Map0.876
3fvqA21100-0.066Contact Map0.77
3d31A20.9807100-0.056Contact Map0.803

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0178 seconds.