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ALPA - Prophage CP4-57 regulatory protein AlpA
UniProt: P33997 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12112
Length: 70 (60)
Sequences: 621
Seq/Len: 10.35

ALPA
Paralog alert: 0.55 [within 20: 0.04] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
9_I 53_G 5.011 1.00
30_L 44_K 3.162 1.00
9_I 63_L 2.506 1.00
18_K 60_D 2.339 1.00
29_W 40_T 2.079 1.00
55_I 58_E 1.984 1.00
27_Y 30_L 1.974 1.00
16_I 26_I 1.872 1.00
12_L 16_I 1.824 1.00
8_R 56_E 1.68 1.00
11_R 20_G 1.657 1.00
48_G 51_S 1.619 1.00
25_T 29_W 1.47 1.00
14_A 17_Q 1.382 0.99
11_R 53_G 1.378 0.99
45_R 55_I 1.311 0.99
11_R 51_S 1.31 0.99
21_M 29_W 1.265 0.99
10_L 14_A 1.241 0.98
18_K 56_E 1.191 0.98
61_E 65_Q 1.179 0.98
7_V 57_A 1.15 0.97
16_I 22_A 1.127 0.97
55_I 67_C 1.124 0.97
10_L 56_E 1.096 0.96
24_A 28_D 1.088 0.96
15_V 26_I 1.074 0.95
27_Y 54_W 1.044 0.94
10_L 15_V 1.039 0.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1z4hA10.999.40.391Contact Map0.502
1y6uA10.885798.90.507Contact Map0.584
4j2nA50.828698.50.573Contact Map0.754
1j9iA20.785798.20.604Contact Map0.705
2kfsA10.885797.10.683Contact Map0.571
2og0A20.796.60.703Contact Map0.747
2jmlA10.857193.60.757Contact Map0.455
2kvvA10.914390.70.777Contact Map0.661
2zhgA10.990.70.777Contact Map0.626
2ao9A90.986.80.792Contact Map0.581

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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