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COBS - Cobalamin synthase
UniProt: P36561 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12150
Length: 247 (245)
Sequences: 1243
Seq/Len: 5.07

COBS
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
99_R 102_E 4.598 1.00
100_M 222_T 3.453 1.00
88_C 116_A 3.012 1.00
93_S 103_I 3.001 1.00
84_L 120_V 2.691 1.00
101_L 227_T 2.662 1.00
85_A 117_L 2.624 1.00
153_A 235_I 2.603 1.00
12_I 37_F 2.598 1.00
78_G 115_L 2.564 1.00
85_A 113_G 2.471 1.00
219_L 230_T 2.405 1.00
69_V 125_I 2.402 1.00
48_S 72_L 2.399 1.00
9_L 43_L 2.254 1.00
73_V 119_F 2.195 1.00
90_G 104_M 2.152 1.00
145_A 242_F 2.086 1.00
149_S 235_I 2.067 1.00
163_A 227_T 2.043 1.00
109_L 114_G 1.938 1.00
51_V 71_V 1.909 1.00
124_K 236_E 1.905 1.00
164_R 227_T 1.905 1.00
5_F 9_L 1.865 1.00
87_T 230_T 1.805 1.00
6_W 18_P 1.794 1.00
64_A 68_S 1.79 1.00
120_V 240_L 1.757 1.00
91_V 223_L 1.725 1.00
109_L 113_G 1.714 1.00
91_V 100_M 1.714 1.00
95_R 99_R 1.701 1.00
122_L 125_I 1.688 0.99
70_L 119_F 1.68 0.99
87_T 91_V 1.67 0.99
104_M 227_T 1.663 0.99
48_S 68_S 1.647 0.99
84_L 116_A 1.622 0.99
81_L 236_E 1.622 0.99
44_L 75_M 1.611 0.99
13_T 44_L 1.601 0.99
66_L 122_L 1.599 0.99
52_F 68_S 1.593 0.99
11_F 79_F 1.552 0.99
84_L 88_C 1.484 0.98
66_L 123_A 1.48 0.98
157_M 231_L 1.444 0.98
124_K 239_E 1.444 0.98
101_L 164_R 1.443 0.98
120_V 236_E 1.429 0.98
10_S 17_V 1.388 0.97
156_L 234_A 1.384 0.97
146_C 236_E 1.346 0.97
211_A 241_V 1.335 0.96
67_F 244_L 1.318 0.96
111_T 115_L 1.304 0.96
160_H 220_K 1.298 0.96
97_R 100_M 1.278 0.95
90_G 107_S 1.278 0.95
160_H 231_L 1.275 0.95
118_I 121_V 1.275 0.95
93_S 100_M 1.271 0.95
84_L 237_L 1.24 0.94
226_Q 230_T 1.234 0.94
45_G 49_G 1.233 0.94
101_L 163_A 1.22 0.93
85_A 109_L 1.219 0.93
8_M 33_G 1.216 0.93
81_L 93_S 1.194 0.92
112_H 226_Q 1.178 0.91
91_V 230_T 1.168 0.91
12_I 40_I 1.159 0.91
72_L 231_L 1.154 0.90
12_I 153_A 1.151 0.90
108_R 111_T 1.132 0.89
13_T 17_V 1.13 0.89
34_I 157_M 1.123 0.89
93_S 112_H 1.12 0.88
124_K 240_L 1.12 0.88
5_F 36_T 1.115 0.88
44_L 146_C 1.11 0.88
217_Q 220_K 1.107 0.88
170_N 174_G 1.098 0.87
146_C 239_E 1.097 0.87
177_D 180_Q 1.091 0.87
92_F 112_H 1.086 0.86
215_L 219_L 1.081 0.86
111_T 114_G 1.081 0.86
11_F 77_G 1.079 0.86
33_G 37_F 1.077 0.86
79_F 95_R 1.076 0.86
145_A 243_L 1.056 0.84
107_S 111_T 1.055 0.84
215_L 234_A 1.052 0.84
100_M 223_L 1.047 0.84
115_L 121_V 1.046 0.83
109_L 117_L 1.04 0.83
60_G 63_L 1.038 0.83
81_L 169_G 1.029 0.82
95_R 103_I 1.028 0.82
67_F 123_A 1.028 0.82
151_G 185_L 1.026 0.82
78_G 112_H 1.024 0.82
169_G 236_E 1.023 0.82
12_I 33_G 1.016 0.81
62_P 125_I 1.015 0.81
97_R 101_L 1.012 0.81
81_L 117_L 1.007 0.80
72_L 146_C 1.006 0.80
124_K 150_R 1.003 0.80
7_A 10_S 1 0.79
66_L 125_I 1 0.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results:
PDB Chains Cov P(%) HHΔ   Acc
3j45G10.24291.40.972Contact Map0.078
2jttC20.12961.40.972Contact Map0.391
3rr6A10.23080.90.975Contact Map0.434
3l53A60.19840.80.976Contact Map0.49
2ls2A10.10120.70.977Contact Map0.371
1sawA20.24290.70.977Contact Map0.413
3lw5I10.11740.60.978Contact Map0
3rf3C20.11740.50.979Contact Map0.655
3llqA20.23480.50.979Contact Map0
1dtcA10.08910.50.979Contact Map0.161

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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