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COBT - Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
UniProt: P36562 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12151
Length: 359 (346)
Sequences: 1027
Seq/Len: 2.97

COBT
Paralog alert: 0.09 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
75_E 137_N 3.793 1.00
202_I 208_T 3.131 1.00
132_A 148_Q 2.964 1.00
115_V 246_G 2.958 1.00
190_T 222_I 2.59 1.00
141_A 225_N 2.457 1.00
187_I 235_V 2.365 1.00
73_W 179_A 2.318 1.00
138_I 221_A 2.205 1.00
93_T 126_L 2.159 1.00
82_K 118_D 2.157 1.00
31_K 40_E 2.138 1.00
99_V 323_A 2.132 1.00
288_P 306_L 2.132 1.00
19_M 48_G 2.131 1.00
152_L 245_V 2.087 1.00
136_G 141_A 2.057 1.00
165_K 257_C 2.032 1.00
132_A 242_F 2.006 1.00
213_N 217_V 1.982 1.00
74_E 140_S 1.981 1.00
104_E 338_N 1.966 1.00
63_V 323_A 1.962 1.00
206_L 210_K 1.944 0.99
61_K 330_E 1.927 0.99
197_E 219_R 1.925 0.99
92_M 176_L 1.898 0.99
188_V 300_A 1.883 0.99
42_L 287_I 1.86 0.99
46_L 333_C 1.846 0.99
202_I 211_L 1.834 0.99
247_I 271_A 1.818 0.99
22_A 47_A 1.817 0.99
288_P 301_L 1.785 0.99
63_V 172_G 1.749 0.99
129_M 158_C 1.723 0.98
210_K 213_N 1.717 0.98
207_P 210_K 1.701 0.98
291_L 311_N 1.676 0.98
30_L 91_N 1.669 0.98
145_S 148_Q 1.663 0.98
115_V 155_D 1.659 0.98
277_Q 303_H 1.654 0.98
120_A 130_R 1.627 0.98
91_N 96_T 1.614 0.97
28_G 343_A 1.613 0.97
75_E 139_A 1.605 0.97
135_S 144_M 1.605 0.97
282_I 286_L 1.604 0.97
161_Q 257_C 1.595 0.97
38_K 41_V 1.583 0.97
200_V 218_V 1.571 0.97
189_S 222_I 1.566 0.97
64_L 113_I 1.561 0.97
173_V 247_I 1.538 0.96
196_P 219_R 1.521 0.96
262_L 329_I 1.517 0.96
272_A 286_L 1.495 0.95
72_V 182_T 1.492 0.95
98_G 339_M 1.488 0.95
141_A 224_L 1.487 0.95
44_I 48_G 1.473 0.95
136_G 148_Q 1.468 0.95
342_L 345_S 1.465 0.95
49_M 285_Y 1.461 0.95
25_H 344_A 1.46 0.95
88_Q 204_A 1.45 0.94
195_D 219_R 1.449 0.94
309_Y 328_I 1.441 0.94
45_Q 287_I 1.435 0.94
68_A 183_P 1.434 0.94
19_M 23_Q 1.434 0.94
23_Q 27_D 1.433 0.94
87_I 347_I 1.431 0.94
42_L 329_I 1.42 0.94
153_L 248_A 1.413 0.93
276_C 281_A 1.412 0.93
14_I 19_M 1.412 0.93
219_R 223_T 1.406 0.93
66_M 250_V 1.405 0.93
216_D 220_R 1.401 0.93
211_L 215_I 1.396 0.93
202_I 295_K 1.382 0.92
185_A 199_V 1.366 0.92
342_L 347_I 1.363 0.92
66_M 246_G 1.362 0.92
208_T 211_L 1.36 0.92
118_D 133_R 1.356 0.91
164_A 259_L 1.355 0.91
114_D 130_R 1.316 0.90
66_M 247_I 1.315 0.90
27_D 33_V 1.314 0.90
216_D 219_R 1.31 0.89
263_L 288_P 1.303 0.89
196_P 218_V 1.301 0.89
324_L 331_A 1.292 0.88
130_R 133_R 1.289 0.88
72_V 138_I 1.286 0.88
234_D 238_K 1.285 0.88
161_Q 253_G 1.282 0.88
146_R 234_D 1.28 0.88
172_G 323_A 1.278 0.88
188_V 199_V 1.277 0.88
34_G 315_R 1.275 0.88
225_N 238_K 1.265 0.87
30_L 96_T 1.264 0.87
154_L 157_I 1.252 0.86
109_N 168_V 1.25 0.86
270_A 300_A 1.248 0.86
201_G 294_E 1.246 0.86
30_L 342_L 1.243 0.86
131_V 242_F 1.235 0.85
30_L 345_S 1.228 0.85
63_V 99_V 1.226 0.85
172_G 322_A 1.224 0.85
18_A 48_G 1.221 0.84
154_L 158_C 1.215 0.84
194_R 198_E 1.205 0.83
132_A 136_G 1.198 0.83
120_A 133_R 1.192 0.82
269_Y 297_A 1.177 0.81
73_W 82_K 1.176 0.81
31_K 339_M 1.174 0.81
159_Y 253_G 1.169 0.81
33_V 80_S 1.159 0.80
89_A 117_I 1.149 0.79
75_E 140_S 1.148 0.79
23_Q 44_I 1.147 0.79
206_L 211_L 1.144 0.79
253_G 257_C 1.142 0.78
276_C 283_K 1.138 0.78
20_S 24_R 1.137 0.78
26_I 335_I 1.136 0.78
144_M 242_F 1.135 0.78
192_T 303_H 1.124 0.77
97_T 100_C 1.124 0.77
88_Q 97_T 1.118 0.76
26_I 43_A 1.118 0.76
102_L 335_I 1.117 0.76
7_L 154_L 1.112 0.76
60_K 109_N 1.11 0.76
153_L 233_V 1.108 0.76
74_E 137_N 1.106 0.75
146_R 231_D 1.105 0.75
108_A 326_M 1.104 0.75
30_L 340_G 1.1 0.75
12_P 258_G 1.078 0.73
139_A 220_R 1.074 0.72
64_L 163_L 1.074 0.72
38_K 307_E 1.069 0.72
234_D 237_A 1.069 0.72
60_K 169_T 1.068 0.72
105_Q 334_A 1.063 0.71
131_V 152_L 1.062 0.71
101_V 104_E 1.058 0.71
67_C 89_A 1.057 0.71
334_A 338_N 1.055 0.70
233_V 278_M 1.051 0.70
151_K 155_D 1.046 0.69
181_T 214_K 1.044 0.69
215_I 219_R 1.043 0.69
100_C 320_S 1.04 0.69
131_V 148_Q 1.037 0.68
341_E 345_S 1.033 0.68
160_T 171_F 1.03 0.68
138_I 186_A 1.028 0.67
171_F 254_A 1.022 0.67
63_V 108_A 1.021 0.67
86_A 119_T 1.019 0.66
70_H 243_D 1.017 0.66
16_S 19_M 1.014 0.66
150_E 154_L 1.01 0.65
74_E 82_K 1.009 0.65
106_A 331_A 1.009 0.65
178_M 204_A 1.001 0.64
14_I 284_P 1.001 0.64
18_A 51_G 1 0.64
160_T 250_V 1 0.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4hdrA20.95821000.038Contact Map0.649
1l5oA10.98611000.038Contact Map0.691
1wx1A20.93041000.061Contact Map0.787
4hdrB20.95541000.101Contact Map0.613
3l0zA30.87471000.44Contact Map0.386
3u4gA10.81341000.502Contact Map0.458
1g8fA10.72731.50.972Contact Map0.032
3kyjB10.37886.40.98Contact Map0.169
3ph3A20.42625.80.98Contact Map0.118
3he8A20.37055.20.981Contact Map0.111

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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