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CUEO - Blue copper oxidase CueO
UniProt: P36649 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12318
Length: 516 (516)
Sequences: 2230
Seq/Len: 4.32

CUEO
Paralog alert: 0.59 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: CUEO FTSP
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
79_K 163_E 5.282 1.00
87_T 128_T 4.481 1.00
279_E 470_K 4.354 1.00
85_A 128_T 3.991 1.00
90_I 119_I 3.724 1.00
230_W 284_L 3.716 1.00
77_A 159_L 3.428 1.00
49_Q 89_D 3.372 1.00
275_V 281_F 3.181 1.00
434_I 445_F 3.114 1.00
49_Q 91_Y 2.968 1.00
183_V 235_L 2.808 1.00
89_D 126_S 2.77 1.00
140_F 158_G 2.739 1.00
235_L 283_V 2.682 1.00
235_L 246_F 2.63 1.00
254_L 283_V 2.626 1.00
239_C 244_L 2.595 1.00
91_Y 124_K 2.593 1.00
55_G 68_G 2.512 1.00
82_R 164_D 2.511 1.00
120_P 123_G 2.426 1.00
51_T 93_Q 2.4 1.00
159_L 236_L 2.358 1.00
280_R 471_D 2.321 1.00
456_S 481_E 2.301 1.00
258_A 282_E 2.273 1.00
184_I 238_G 2.241 1.00
243_S 474_K 2.233 1.00
57_S 66_T 2.148 1.00
501_H 505_H 2.144 1.00
499_H 505_H 2.13 1.00
248_T 295_L 2.092 1.00
230_W 286_E 2.061 1.00
67_W 95_T 2.03 1.00
253_P 269_K 1.999 1.00
47_R 87_T 1.997 1.00
433_V 481_E 1.996 1.00
54_A 65_T 1.994 1.00
81_Q 163_E 1.981 1.00
47_R 89_D 1.975 1.00
473_V 480_S 1.967 1.00
431_R 455_L 1.948 1.00
500_C 505_H 1.881 1.00
52_I 90_I 1.813 1.00
111_V 125_R 1.787 1.00
159_L 184_I 1.783 1.00
486_F 490_A 1.782 1.00
235_L 273_L 1.764 1.00
248_T 285_V 1.761 0.99
497_M 511_M 1.723 0.99
52_I 69_Y 1.717 0.99
67_W 154_M 1.716 0.99
431_R 483_L 1.71 0.99
89_D 124_K 1.706 0.99
56_Q 63_T 1.682 0.99
454_I 473_V 1.681 0.99
56_Q 65_T 1.676 0.99
66_T 188_K 1.669 0.99
68_G 73_L 1.661 0.99
86_V 160_V 1.659 0.99
76_P 158_G 1.651 0.99
486_F 489_D 1.629 0.99
5_D 8_K 1.609 0.99
137_T 234_R 1.59 0.99
191_S 195_Q 1.586 0.99
185_V 246_F 1.581 0.99
256_V 281_F 1.556 0.98
506_E 511_M 1.553 0.98
262_G 451_Q 1.545 0.98
157_A 238_G 1.526 0.98
157_A 186_Q 1.504 0.98
232_R 257_I 1.502 0.98
226_A 287_V 1.501 0.98
48_I 80_L 1.5 0.98
490_A 494_H 1.494 0.98
425_A 428_Q 1.492 0.98
443_H 500_C 1.484 0.98
245_N 274_P 1.484 0.98
76_P 140_F 1.468 0.98
253_P 271_S 1.467 0.98
53_G 93_Q 1.467 0.98
143_H 501_H 1.466 0.98
142_P 151_Q 1.461 0.97
449_G 496_Y 1.458 0.97
80_L 162_I 1.455 0.97
248_T 254_L 1.455 0.97
143_H 500_C 1.454 0.97
495_A 515_T 1.448 0.97
233_L 283_V 1.437 0.97
273_L 281_F 1.429 0.97
102_W 129_L 1.42 0.97
246_F 295_L 1.418 0.97
431_R 481_E 1.417 0.97
4_R 7_L 1.413 0.97
153_A 240_N 1.413 0.97
58_T 61_G 1.413 0.97
434_I 498_A 1.406 0.97
138_C 261_G 1.405 0.97
433_V 479_V 1.399 0.96
152_V 503_L 1.396 0.96
246_F 273_L 1.394 0.96
3_R 6_F 1.386 0.96
232_R 282_E 1.386 0.96
443_H 501_H 1.383 0.96
75_G 218_G 1.381 0.96
234_R 282_E 1.378 0.96
503_L 506_E 1.363 0.96
85_A 130_N 1.346 0.95
80_L 86_V 1.344 0.95
475_V 480_S 1.344 0.95
434_I 482_V 1.338 0.95
453_R 469_W 1.336 0.95
103_H 500_C 1.334 0.95
443_H 505_H 1.315 0.94
99_T 102_W 1.313 0.94
180_D 232_R 1.308 0.94
90_I 98_T 1.306 0.94
416_D 419_K 1.303 0.94
143_H 505_H 1.298 0.94
103_H 143_H 1.297 0.94
424_A 430_E 1.297 0.94
180_D 234_R 1.289 0.94
101_H 448_H 1.288 0.94
103_H 499_H 1.286 0.94
97_E 120_P 1.283 0.93
54_A 95_T 1.279 0.93
52_I 98_T 1.277 0.93
143_H 499_H 1.276 0.93
423_A 515_T 1.275 0.93
46_N 84_K 1.274 0.93
444_P 502_L 1.269 0.93
82_R 165_D 1.266 0.93
159_L 182_P 1.263 0.93
3_R 7_L 1.263 0.93
252_R 293_F 1.262 0.93
255_Y 269_K 1.256 0.93
273_L 283_V 1.251 0.92
143_H 443_H 1.249 0.92
443_H 448_H 1.247 0.92
170_L 263_L 1.245 0.92
443_H 499_H 1.243 0.92
229_G 287_V 1.241 0.92
487_N 490_A 1.241 0.92
445_F 498_A 1.24 0.92
103_H 505_H 1.239 0.92
410_I 445_F 1.238 0.92
133_Q 162_I 1.235 0.92
351_L 355_M 1.231 0.92
256_V 270_V 1.228 0.91
102_W 449_G 1.226 0.91
77_A 182_P 1.224 0.91
495_A 513_G 1.217 0.91
240_N 504_E 1.214 0.91
57_S 68_G 1.212 0.91
51_T 91_Y 1.209 0.91
290_N 293_F 1.205 0.90
276_L 474_K 1.2 0.90
101_H 143_H 1.198 0.90
48_I 86_V 1.192 0.90
119_I 125_R 1.187 0.89
452_F 482_V 1.187 0.89
103_H 501_H 1.184 0.89
98_T 151_Q 1.184 0.89
143_H 448_H 1.178 0.89
259_S 470_K 1.178 0.89
457_E 478_N 1.171 0.89
245_N 272_E 1.17 0.89
285_V 295_L 1.163 0.88
69_Y 156_L 1.158 0.88
99_T 115_P 1.154 0.88
103_H 443_H 1.154 0.88
113_G 116_Q 1.151 0.87
350_K 431_R 1.147 0.87
484_V 488_H 1.145 0.87
101_H 499_H 1.134 0.86
87_T 126_S 1.133 0.86
129_L 160_V 1.125 0.86
90_I 102_W 1.124 0.86
235_L 275_V 1.121 0.86
259_S 281_F 1.121 0.86
167_I 170_L 1.117 0.85
141_H 500_C 1.111 0.85
101_H 500_C 1.11 0.85
148_T 506_E 1.102 0.84
226_A 231_L 1.102 0.84
90_I 100_L 1.095 0.84
448_H 501_H 1.093 0.84
101_H 501_H 1.09 0.83
80_L 160_V 1.087 0.83
448_H 499_H 1.086 0.83
448_H 500_C 1.085 0.83
287_V 319_I 1.085 0.83
258_A 263_L 1.083 0.83
103_H 448_H 1.078 0.82
261_G 451_Q 1.078 0.82
77_A 140_F 1.076 0.82
448_H 505_H 1.075 0.82
101_H 443_H 1.07 0.82
60_G 190_F 1.065 0.81
137_T 159_L 1.064 0.81
225_A 320_Q 1.064 0.81
81_Q 84_K 1.06 0.81
436_G 476_E 1.058 0.81
454_I 480_S 1.058 0.81
249_S 296_V 1.057 0.81
67_W 94_L 1.05 0.80
247_A 272_E 1.046 0.80
59_F 190_F 1.041 0.79
78_V 160_V 1.04 0.79
231_L 287_V 1.039 0.79
1_M 10_S 1.038 0.79
60_G 64_A 1.038 0.79
376_M 379_M 1.036 0.79
233_L 285_V 1.034 0.79
54_A 68_G 1.033 0.78
254_L 285_V 1.028 0.78
429_Y 485_K 1.026 0.78
131_V 160_V 1.024 0.78
458_N 478_N 1.021 0.77
484_V 490_A 1.021 0.77
490_A 493_E 1.019 0.77
223_Q 320_Q 1.018 0.77
2_Q 5_D 1.016 0.77
101_H 505_H 1.013 0.77
67_W 156_L 1.012 0.76
6_F 10_S 1.011 0.76
181_V 224_H 1.004 0.76
35_P 219_A 1.003 0.76
444_P 501_H 1 0.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4e9sA10.94571000.168Contact Map0.738
2uxtA20.83141000.213Contact Map0.729
2xu9A10.82171000.228Contact Map0.742
3zx1A10.90311000.231Contact Map0.696
3abgA20.85271000.238Contact Map0.71
2wsdA10.85081000.256Contact Map0.756
2g23A120.92641000.259Contact Map0.756
3aw5A10.81591000.263Contact Map0.716
1zpuA60.8451000.281Contact Map0.758
4f7kA20.77131000.294Contact Map0.649

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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