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CBPA - Curved DNA-binding protein
UniProt: P36659 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12193
Length: 306 (294)
Sequences: 4222
Seq/Len: 14.36

CBPA
Paralog alert: 0.50 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: CBPA DNAJ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
17_D 20_T 4.814 1.00
18_L 59_E 3.569 1.00
221_E 226_A 3.5 1.00
129_E 201_H 3.215 1.00
132_L 258_L 3.161 1.00
30_R 36_V 3.084 1.00
43_E 47_K 3.051 1.00
282_N 289_Q 3.01 1.00
158_K 179_Q 2.995 1.00
136_K 163_K 2.842 1.00
130_E 137_R 2.808 1.00
136_K 161_N 2.742 1.00
4_K 48_E 2.72 1.00
212_E 270_V 2.681 1.00
127_F 130_E 2.649 1.00
218_S 221_E 2.634 1.00
280_D 283_T 2.614 1.00
227_K 238_L 2.605 1.00
127_F 199_A 2.544 1.00
211_L 267_L 2.473 1.00
229_T 236_S 2.434 1.00
284_A 288_Q 2.427 1.00
214_V 270_V 2.424 1.00
123_E 197_H 2.389 1.00
216_P 274_V 2.312 1.00
245_S 271_L 2.284 1.00
209_Q 260_S 2.272 1.00
216_P 272_K 2.261 1.00
214_V 272_K 2.208 1.00
286_L 289_Q 2.175 1.00
282_N 285_A 2.161 1.00
170_N 197_H 2.146 1.00
63_A 67_Q 2.119 1.00
250_R 268_Y 2.107 1.00
6_Y 55_V 2.089 1.00
37_S 42_A 2.082 1.00
138_T 159_T 2.041 1.00
125_A 199_A 2.004 1.00
227_K 240_T 1.98 1.00
125_A 197_H 1.969 1.00
16_D 21_I 1.963 1.00
251_L 271_L 1.95 1.00
247_A 275_M 1.924 1.00
5_D 8_A 1.892 1.00
170_N 198_I 1.887 1.00
6_Y 51_E 1.878 1.00
12_V 21_I 1.875 1.00
130_E 135_H 1.871 1.00
252_R 266_D 1.85 1.00
140_S 157_P 1.84 1.00
19_K 23_T 1.834 1.00
285_A 289_Q 1.822 1.00
138_T 161_N 1.744 1.00
229_T 238_L 1.73 1.00
40_P 43_E 1.714 1.00
250_R 270_V 1.707 1.00
60_Q 63_A 1.706 1.00
13_K 20_T 1.692 1.00
4_K 8_A 1.677 1.00
28_L 49_V 1.66 1.00
203_L 213_I 1.628 1.00
41_D 44_A 1.624 1.00
211_L 258_L 1.618 1.00
221_E 291_A 1.607 1.00
60_Q 64_E 1.593 1.00
32_Y 49_V 1.58 1.00
121_E 195_V 1.579 1.00
173_R 193_W 1.566 1.00
118_H 181_T 1.561 1.00
168_V 172_Q 1.561 1.00
45_R 48_E 1.558 1.00
215_V 228_V 1.535 1.00
212_E 268_Y 1.531 1.00
234_K 264_T 1.519 1.00
255_G 266_D 1.513 1.00
123_E 195_V 1.503 1.00
219_P 223_A 1.486 1.00
64_E 68_M 1.474 1.00
128_L 211_L 1.466 1.00
4_K 9_I 1.464 1.00
15_T 20_T 1.463 1.00
28_L 31_K 1.438 1.00
132_L 233_L 1.436 1.00
219_P 287_W 1.42 1.00
285_A 288_Q 1.397 0.99
200_P 205_D 1.39 0.99
223_A 275_M 1.382 0.99
168_V 196_I 1.376 0.99
169_G 209_Q 1.361 0.99
233_L 267_L 1.36 0.99
140_S 159_T 1.36 0.99
287_W 290_L 1.354 0.99
128_L 258_L 1.335 0.99
283_T 290_L 1.328 0.99
289_Q 292_D 1.315 0.99
126_V 131_T 1.314 0.99
207_V 212_E 1.3 0.99
210_D 268_Y 1.296 0.99
207_V 210_D 1.296 0.99
281_E 288_Q 1.293 0.99
32_Y 45_R 1.285 0.99
131_T 198_I 1.283 0.99
219_P 275_M 1.275 0.99
205_D 214_V 1.265 0.99
231_P 236_S 1.263 0.99
223_A 287_W 1.261 0.99
58_D 61_R 1.26 0.99
59_E 62_R 1.255 0.99
131_T 258_L 1.255 0.99
286_L 290_L 1.233 0.98
210_D 266_D 1.23 0.98
121_E 173_R 1.222 0.98
128_L 131_T 1.212 0.98
213_I 267_L 1.21 0.98
217_V 222_A 1.209 0.98
239_L 251_L 1.194 0.98
25_Y 50_A 1.187 0.98
203_L 231_P 1.185 0.98
243_P 284_A 1.176 0.98
245_S 251_L 1.173 0.98
239_L 269_A 1.172 0.98
242_P 251_L 1.167 0.97
98_F 102_F 1.154 0.97
28_L 32_Y 1.151 0.97
176_L 179_Q 1.144 0.97
279_P 283_T 1.138 0.97
213_I 269_A 1.136 0.97
38_K 41_D 1.134 0.97
124_V 196_I 1.131 0.97
282_N 286_L 1.128 0.97
11_G 24_A 1.12 0.96
128_L 132_L 1.118 0.96
281_E 285_A 1.112 0.96
282_N 293_A 1.11 0.96
29_A 46_F 1.109 0.96
213_I 231_P 1.101 0.96
128_L 198_I 1.095 0.96
246_Q 277_P 1.085 0.96
46_F 50_A 1.074 0.95
160_L 176_L 1.073 0.95
142_N 157_P 1.07 0.95
126_V 130_E 1.065 0.95
288_Q 291_A 1.065 0.95
247_A 272_K 1.06 0.95
5_D 14_P 1.051 0.94
44_A 48_E 1.05 0.94
254_K 266_D 1.047 0.94
213_I 216_P 1.044 0.94
95_D 99_S 1.043 0.94
237_I 256_K 1.043 0.94
131_T 168_V 1.041 0.94
220_W 223_A 1.033 0.94
172_Q 261_K 1.024 0.93
9_I 48_E 1.023 0.93
59_E 63_A 1.02 0.93
288_Q 292_D 1.009 0.93
165_P 168_V 1.007 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3lz8A20.99671000.117Contact Map0.834
4j80A40.89541000.208Contact Map0.776
2q2gA20.57521000.489Contact Map0.825
1c3gA10.54251000.506Contact Map0.801
1nltA10.59151000.508Contact Map0.789
3agxA20.57191000.51Contact Map0.82
3i38A120.35621000.687Contact Map0.892
4j7zA60.352999.90.703Contact Map0.835
1bq0A10.330199.90.714Contact Map0.362
2ctqA10.303999.90.734Contact Map0.451

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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