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YADG - Uncharacterized ABC transporter ATP-binding protein YadG
UniProt: P36879 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12320
Length: 308 (300)
Sequences: 10087
Seq/Len: 33.62

YADG
Paralog alert: 0.89 [within 20: 0.15] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
95_V 137_L 4.208 1.00
79_Q 156_K 3.971 1.00
19_Q 22_R 3.818 1.00
32_D 205_N 3.76 1.00
34_Y 207_G 3.729 1.00
9_Q 23_G 3.677 1.00
22_R 213_E 3.603 1.00
129_K 132_E 3.403 1.00
218_T 222_A 3.265 1.00
8_Q 61_R 3.248 1.00
6_E 27_Q 3.201 1.00
21_L 50_I 3.112 1.00
6_E 63_S 3.073 1.00
13_T 19_Q 3.043 1.00
122_K 127_W 3.008 1.00
30_A 156_K 2.993 1.00
193_T 199_A 2.935 1.00
35_A 203_C 2.89 1.00
7_L 10_L 2.751 1.00
205_N 217_N 2.74 1.00
11_K 23_G 2.502 1.00
29_E 32_D 2.501 1.00
154_E 187_T 2.489 1.00
85_Q 139_G 2.42 1.00
207_G 214_L 2.415 1.00
123_Q 181_D 2.376 1.00
61_R 68_D 2.362 1.00
96_Q 130_R 2.335 1.00
96_Q 131_N 2.281 1.00
11_K 19_Q 2.241 1.00
9_Q 25_D 2.237 1.00
121_L 130_R 2.164 1.00
34_Y 217_N 2.086 1.00
72_D 75_N 2.011 1.00
219_S 222_A 1.982 1.00
24_I 214_L 1.951 1.00
36_L 47_T 1.926 1.00
7_L 26_L 1.917 1.00
65_F 79_Q 1.878 1.00
50_I 62_V 1.876 1.00
103_A 113_A 1.86 1.00
132_E 136_M 1.856 1.00
116_R 119_K 1.856 1.00
26_L 207_G 1.854 1.00
96_Q 118_E 1.844 1.00
36_L 190_I 1.837 1.00
67_Y 72_D 1.763 1.00
8_Q 27_Q 1.699 1.00
11_K 59_S 1.691 1.00
12_K 58_T 1.663 1.00
94_T 97_Q 1.662 1.00
13_T 58_T 1.637 1.00
100_V 113_A 1.63 1.00
65_F 157_L 1.617 1.00
21_L 47_T 1.601 1.00
116_R 154_E 1.599 1.00
109_E 112_E 1.56 1.00
181_D 185_K 1.535 1.00
134_A 145_L 1.522 1.00
24_I 47_T 1.521 1.00
8_Q 25_D 1.52 1.00
67_Y 75_N 1.518 1.00
5_L 51_I 1.514 1.00
75_N 78_R 1.509 1.00
120_Y 148_A 1.484 1.00
50_I 57_K 1.483 1.00
273_T 277_E 1.462 1.00
137_L 141_M 1.461 1.00
127_W 130_R 1.446 1.00
11_K 22_R 1.445 1.00
207_G 217_N 1.433 1.00
18_V 132_E 1.402 0.99
14_Y 20_A 1.388 0.99
102_Q 149_R 1.373 0.99
106_Y 153_H 1.357 0.99
183_N 204_R 1.352 0.99
32_D 204_R 1.339 0.99
9_Q 59_S 1.326 0.99
51_I 62_V 1.323 0.99
68_D 71_K 1.321 0.99
65_F 156_K 1.317 0.99
28_V 34_Y 1.314 0.99
159_I 192_T 1.3 0.99
4_A 65_F 1.3 0.99
119_K 123_Q 1.292 0.99
29_E 205_N 1.275 0.99
154_E 185_K 1.264 0.99
112_E 115_I 1.261 0.99
7_L 62_V 1.253 0.99
96_Q 117_S 1.244 0.98
99_V 152_M 1.243 0.98
233_I 288_K 1.235 0.98
14_Y 55_V 1.23 0.98
179_L 189_I 1.223 0.98
57_K 70_E 1.202 0.98
291_R 294_E 1.202 0.98
39_P 210_Q 1.201 0.98
96_Q 100_V 1.198 0.98
180_K 183_N 1.192 0.98
274_Q 277_E 1.19 0.98
12_K 50_I 1.185 0.98
10_L 62_V 1.181 0.98
129_K 141_M 1.181 0.98
270_S 273_T 1.18 0.98
48_I 192_T 1.18 0.98
37_L 199_A 1.177 0.98
125_D 174_S 1.174 0.98
8_Q 63_S 1.17 0.97
200_E 224_L 1.167 0.97
7_L 50_I 1.166 0.97
98_I 134_A 1.163 0.97
181_D 184_D 1.154 0.97
159_I 190_I 1.149 0.97
118_E 130_R 1.131 0.97
180_K 201_M 1.129 0.97
52_S 159_I 1.124 0.97
200_E 220_M 1.123 0.97
144_R 148_A 1.121 0.97
156_K 187_T 1.117 0.96
95_V 145_L 1.107 0.96
296_F 300_V 1.106 0.96
118_E 122_K 1.104 0.96
7_L 47_T 1.101 0.96
100_V 114_Y 1.097 0.96
176_W 198_E 1.095 0.96
5_L 157_L 1.087 0.96
33_F 183_N 1.081 0.95
33_F 179_L 1.077 0.95
81_G 153_H 1.075 0.95
110_R 113_A 1.073 0.95
124_L 148_A 1.072 0.95
67_Y 79_Q 1.068 0.95
40_N 194_H 1.066 0.95
81_G 155_P 1.048 0.94
83_V 150_A 1.043 0.94
113_A 117_S 1.043 0.94
67_Y 76_A 1.032 0.94
119_K 154_E 1.021 0.93
115_I 119_K 1.014 0.93
103_A 108_V 1.012 0.93
172_R 195_Y 1.011 0.93
103_A 152_M 1.007 0.93
273_T 276_S 1.005 0.93
100_V 117_S 1.002 0.92
139_G 176_W 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tuiC40.99681000.21Contact Map0.813
1vplA10.79551000.229Contact Map0.828
2oljA20.7761000.233Contact Map0.804
1v43A10.9741000.237Contact Map0.795
1oxxK10.98381000.241Contact Map0.741
4mkiB20.91561000.242Contact Map0.773
1z47A20.98381000.242Contact Map0.774
3fvqA20.99031000.242Contact Map0.725
2it1A20.97731000.244Contact Map0.82
1b0uA10.79221000.245Contact Map0.724

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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