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FBPC - Fe(3+) ions import ATP-binding protein FbpC
UniProt: P37009 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12340
Length: 348 (342)
Sequences: 8972
Seq/Len: 26.23

FBPC
Paralog alert: 0.82 [within 20: 0.12] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
219_G 223_D 4.554 1.00
36_T 204_S 4.291 1.00
122_A 127_E 4.116 1.00
33_Q 206_T 3.788 1.00
62_Q 69_D 3.764 1.00
216_M 230_S 3.645 1.00
8_E 28_T 3.365 1.00
292_C 308_V 3.34 1.00
114_K 118_K 3.151 1.00
10_R 62_Q 3.134 1.00
109_P 112_E 2.958 1.00
11_N 24_N 2.831 1.00
295_R 309_E 2.826 1.00
129_F 132_R 2.755 1.00
23_D 214_H 2.664 1.00
96_G 131_D 2.644 1.00
96_G 100_G 2.557 1.00
11_N 26_N 2.551 1.00
116_R 154_K 2.544 1.00
96_G 118_K 2.511 1.00
121_L 130_E 2.473 1.00
181_E 185_Q 2.445 1.00
66_D 156_K 2.441 1.00
220_S 223_D 2.413 1.00
208_L 215_I 2.406 1.00
96_G 117_V 2.404 1.00
293_V 331_Q 2.4 1.00
35_V 208_L 2.391 1.00
291_R 331_Q 2.388 1.00
51_L 63_I 2.336 1.00
120_A 152_I 2.316 1.00
96_G 114_K 2.265 1.00
65_I 70_V 2.246 1.00
68_E 156_K 2.226 1.00
22_I 51_L 2.182 1.00
7_V 157_V 2.142 1.00
208_L 218_I 2.09 1.00
52_V 191_L 2.082 1.00
20_T 23_D 2.079 1.00
211_N 216_M 2.071 1.00
8_E 64_F 2.042 1.00
30_P 33_Q 2.029 1.00
100_G 117_V 2.007 1.00
79_D 156_K 1.99 1.00
9_L 12_V 1.987 1.00
327_D 330_E 1.963 1.00
231_R 272_M 1.954 1.00
291_R 333_Y 1.891 1.00
293_V 309_E 1.884 1.00
50_R 56_E 1.875 1.00
97_E 104_K 1.873 1.00
64_F 69_D 1.865 1.00
13_T 24_N 1.862 1.00
160_F 190_S 1.853 1.00
15_R 20_T 1.82 1.00
115_A 119_E 1.819 1.00
10_R 64_F 1.81 1.00
9_L 52_V 1.81 1.00
125_D 174_S 1.809 1.00
13_T 60_E 1.794 1.00
112_E 115_A 1.784 1.00
13_T 20_T 1.767 1.00
209_V 233_M 1.736 1.00
14_K 51_L 1.732 1.00
100_G 113_L 1.708 1.00
68_E 73_R 1.688 1.00
113_L 117_V 1.675 1.00
231_R 235_S 1.663 1.00
124_V 148_A 1.633 1.00
90_F 102_G 1.63 1.00
225_Y 278_E 1.628 1.00
108_V 113_L 1.624 1.00
231_R 242_L 1.617 1.00
111_A 115_A 1.611 1.00
99_V 148_A 1.603 1.00
94_S 97_E 1.593 1.00
51_L 58_P 1.592 1.00
35_V 218_I 1.585 1.00
108_V 112_E 1.585 1.00
14_K 56_E 1.581 1.00
246_T 270_E 1.579 1.00
240_A 274_G 1.548 1.00
235_S 242_L 1.533 1.00
70_V 73_R 1.513 1.00
22_I 48_I 1.505 1.00
118_K 130_E 1.484 1.00
119_E 154_K 1.484 1.00
14_K 59_S 1.473 1.00
116_R 119_E 1.473 1.00
102_G 153_L 1.471 1.00
9_L 27_L 1.461 1.00
112_E 116_R 1.433 1.00
244_P 270_E 1.426 1.00
74_S 77_Q 1.424 1.00
242_L 272_M 1.422 1.00
43_C 210_M 1.421 1.00
64_F 67_G 1.421 1.00
308_V 334_L 1.407 0.99
35_V 206_T 1.399 0.99
99_V 121_L 1.378 0.99
120_A 151_L 1.376 0.99
25_I 48_I 1.374 0.99
94_S 133_F 1.359 0.99
279_A 340_G 1.358 0.99
223_D 227_Q 1.356 0.99
27_L 208_L 1.347 0.99
30_P 206_T 1.343 0.99
119_E 122_A 1.337 0.99
303_Q 318_Q 1.328 0.99
62_Q 71_T 1.316 0.99
15_R 60_E 1.314 0.99
104_K 110_R 1.306 0.99
58_P 63_I 1.296 0.99
183_Q 188_I 1.291 0.99
164_L 179_I 1.29 0.99
297_V 306_V 1.289 0.99
222_Q 226_R 1.284 0.99
211_N 232_F 1.277 0.99
245_A 271_G 1.277 0.99
183_Q 190_S 1.275 0.99
118_K 122_A 1.266 0.99
8_E 67_G 1.263 0.99
180_R 203_V 1.261 0.99
9_L 48_I 1.246 0.98
58_P 71_T 1.235 0.98
281_T 335_E 1.233 0.98
118_K 127_E 1.222 0.98
110_R 114_K 1.221 0.98
22_I 25_I 1.218 0.98
27_L 218_I 1.215 0.98
154_K 185_Q 1.206 0.98
69_D 72_H 1.187 0.98
81_C 153_L 1.183 0.98
101_Y 105_M 1.176 0.98
12_V 58_P 1.159 0.97
37_L 208_L 1.154 0.97
294_I 306_V 1.154 0.97
13_T 23_D 1.149 0.97
34_M 183_Q 1.149 0.97
164_L 192_Y 1.144 0.97
206_T 218_I 1.144 0.97
15_R 21_V 1.137 0.97
244_P 272_M 1.135 0.97
10_R 26_N 1.128 0.97
34_M 203_V 1.126 0.97
73_R 77_Q 1.103 0.96
31_Q 66_D 1.093 0.96
226_R 299_Y 1.09 0.96
280_I 336_I 1.089 0.96
12_V 51_L 1.087 0.96
119_E 185_Q 1.087 0.96
87_Y 166_N 1.084 0.96
217_Q 233_M 1.081 0.95
11_N 60_E 1.078 0.95
219_G 224_L 1.073 0.95
283_S 333_Y 1.07 0.95
227_Q 342_F 1.067 0.95
292_C 332_Y 1.065 0.95
337_H 340_G 1.064 0.95
275_V 280_I 1.063 0.95
125_D 178_K 1.057 0.95
248_S 253_D 1.049 0.94
197_Q 236_F 1.043 0.94
292_C 310_W 1.042 0.94
309_E 312_G 1.042 0.94
170_N 235_S 1.04 0.94
97_E 100_G 1.037 0.94
121_L 126_L 1.032 0.94
308_V 317_L 1.021 0.93
90_F 153_L 1.02 0.93
246_T 253_D 1.005 0.93
63_I 70_V 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2it1A20.98851000.169Contact Map0.861
1v43A10.99711000.171Contact Map0.843
1oxxK10.97411000.175Contact Map0.737
2yyzA10.98561000.19Contact Map0.774
1g29120.98851000.19Contact Map0.872
3rlfA20.98851000.191Contact Map0.818
3fvqA20.98561000.194Contact Map0.748
3d31A20.96261000.201Contact Map0.743
1z47A20.98281000.219Contact Map0.835
3gd7A40.96261000.288Contact Map0.705

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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