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CDAR - Carbohydrate diacid regulator
UniProt: P37047 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12335
Length: 385 (381)
Sequences: 1396
Seq/Len: 3.66

CDAR
Paralog alert: 0.30 [within 20: 0.02] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
251_G 263_S 7.792 1.00
333_H 343_A 4.038 1.00
359_S 365_D 4.013 1.00
318_D 321_G 3.335 1.00
346_I 351_L 3.077 1.00
346_I 350_T 2.862 1.00
249_S 270_T 2.834 1.00
328_A 383_E 2.81 1.00
333_H 340_T 2.724 1.00
15_V 28_V 2.582 1.00
249_S 267_A 2.58 1.00
263_S 267_A 2.455 1.00
364_L 371_D 2.324 1.00
329_A 340_T 2.285 1.00
339_A 342_K 2.26 1.00
331_F 372_R 2.228 1.00
329_A 333_H 2.214 1.00
326_T 354_R 2.164 1.00
166_V 263_S 2.162 1.00
359_S 366_L 2.157 1.00
168_I 267_A 2.137 1.00
12_Q 16_A 2.057 1.00
340_T 351_L 2.04 1.00
138_N 152_W 2.033 1.00
326_T 340_T 2.011 1.00
19_M 39_G 1.968 1.00
317_M 321_G 1.953 1.00
335_V 372_R 1.939 1.00
322_L 325_R 1.914 1.00
29_M 93_G 1.907 1.00
347_H 350_T 1.895 1.00
335_V 340_T 1.855 1.00
256_G 259_S 1.847 1.00
28_V 92_I 1.782 0.99
334_N 369_F 1.769 0.99
332_R 343_A 1.765 0.99
325_R 329_A 1.738 0.99
366_L 372_R 1.699 0.99
267_A 270_T 1.683 0.99
314_L 358_I 1.67 0.99
326_T 358_I 1.661 0.99
290_M 293_V 1.632 0.99
208_E 268_K 1.607 0.98
170_E 275_K 1.605 0.98
274_G 284_Y 1.602 0.98
327_L 358_I 1.576 0.98
249_S 271_M 1.576 0.98
262_R 266_T 1.574 0.98
25_N 95_T 1.557 0.98
368_N 371_D 1.555 0.98
28_V 82_L 1.546 0.98
30_D 34_R 1.545 0.98
336_Q 352_E 1.536 0.98
362_T 371_D 1.514 0.97
314_L 324_R 1.509 0.97
334_N 368_N 1.504 0.97
169_V 248_V 1.474 0.97
344_L 351_L 1.472 0.97
126_A 130_R 1.448 0.96
308_A 378_A 1.448 0.96
92_I 112_A 1.433 0.96
328_A 332_R 1.43 0.96
29_M 77_G 1.423 0.96
261_A 265_R 1.414 0.95
138_N 143_E 1.408 0.95
84_L 89_V 1.405 0.95
323_L 326_T 1.392 0.95
330_W 335_V 1.384 0.95
347_H 353_Y 1.354 0.94
312_A 378_A 1.353 0.94
142_A 261_A 1.339 0.93
33_G 91_V 1.328 0.93
349_N 352_E 1.328 0.93
367_G 372_R 1.325 0.93
25_N 39_G 1.324 0.93
285_F 288_D 1.309 0.92
166_V 267_A 1.304 0.92
111_T 349_N 1.304 0.92
251_G 267_A 1.302 0.92
339_A 343_A 1.301 0.92
338_L 342_K 1.3 0.92
254_F 259_S 1.281 0.91
331_F 335_V 1.269 0.91
249_S 266_T 1.26 0.90
315_K 382_D 1.255 0.90
357_R 360_E 1.247 0.90
136_V 212_L 1.244 0.90
348_R 352_E 1.243 0.90
15_V 26_I 1.243 0.90
326_T 351_L 1.236 0.89
356_N 359_S 1.233 0.89
336_Q 351_L 1.229 0.89
82_L 90_G 1.222 0.88
333_H 339_A 1.221 0.88
335_V 352_E 1.218 0.88
96_G 105_G 1.217 0.88
27_N 77_G 1.213 0.88
33_G 77_G 1.195 0.87
137_M 205_S 1.191 0.87
328_A 382_D 1.189 0.87
373_L 376_Y 1.186 0.86
43_R 47_L 1.18 0.86
33_G 38_S 1.177 0.86
375_L 380_Q 1.176 0.86
232_E 236_T 1.162 0.85
27_N 38_S 1.16 0.85
306_E 312_A 1.159 0.85
22_I 94_L 1.157 0.85
364_L 374_L 1.147 0.84
306_E 378_A 1.145 0.84
348_R 356_N 1.142 0.83
334_N 372_R 1.122 0.82
308_A 316_T 1.119 0.82
156_L 294_L 1.119 0.82
127_Q 130_R 1.117 0.82
79_N 93_G 1.117 0.82
251_G 365_D 1.116 0.82
40_D 43_R 1.115 0.81
331_F 376_Y 1.111 0.81
330_W 355_L 1.11 0.81
251_G 261_A 1.11 0.81
322_L 332_R 1.109 0.81
337_P 352_E 1.108 0.81
160_L 257_P 1.106 0.81
142_A 164_R 1.105 0.81
336_Q 348_R 1.105 0.81
366_L 371_D 1.105 0.81
338_L 348_R 1.1 0.80
11_A 35_I 1.1 0.80
264_Y 268_K 1.099 0.80
292_P 370_D 1.096 0.80
313_R 361_L 1.094 0.80
372_R 376_Y 1.091 0.79
131_L 348_R 1.09 0.79
112_A 330_W 1.09 0.79
255_T 259_S 1.089 0.79
259_S 262_R 1.088 0.79
266_T 270_T 1.083 0.79
250_L 288_D 1.082 0.79
17_R 20_R 1.082 0.79
307_L 312_A 1.081 0.79
337_P 351_L 1.08 0.78
252_N 266_T 1.078 0.78
99_E 102_R 1.075 0.78
111_T 347_H 1.073 0.78
104_Y 108_V 1.073 0.78
337_P 349_N 1.064 0.77
170_E 247_R 1.06 0.77
235_I 248_V 1.046 0.75
15_V 37_G 1.045 0.75
11_A 27_N 1.045 0.75
353_Y 360_E 1.038 0.75
250_L 285_F 1.036 0.74
314_L 361_L 1.028 0.74
231_V 248_V 1.023 0.73
254_F 266_T 1.023 0.73
293_V 309_R 1.021 0.73
370_D 380_Q 1.021 0.73
312_A 316_T 1.021 0.73
369_F 376_Y 1.019 0.73
15_V 90_G 1.015 0.72
116_L 120_R 1.013 0.72
270_T 274_G 1.01 0.72
238_M 330_W 1.006 0.71
4_W 9_K 1.006 0.71
62_D 102_R 1.003 0.71
135_L 152_W 1.003 0.71
210_V 264_Y 1.002 0.71
19_M 28_V 1.001 0.71
47_L 55_L 1 0.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3onqA40.67271000.444Contact Map0.679
2gx5A40.324797.40.892Contact Map0.588
2w1rA10.2961950.915Contact Map0.708
1etoA20.210494.20.918Contact Map0.722
3mz1A40.163694.10.918Contact Map
3szpA20.171494.10.919Contact Map0.621
3qyyA20.410493.60.92Contact Map0.663
3hvaA20.415693.60.92Contact Map0.643
3ispA20.184493.20.921Contact Map0.645
1al3A10.174930.922Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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