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ARCC - Carbamate kinase
UniProt: P37306 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12384
Length: 297 (295)
Sequences: 619
Seq/Len: 2.10

ARCC
Paralog alert: 0.46 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: ARCC ARCL ARCM
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
130_P 134_E 5.089 1.00
248_A 269_R 3.981 1.00
230_N 235_Q 3.602 1.00
242_A 247_L 3.551 1.00
228_Y 238_A 2.814 1.00
36_L 45_L 2.813 1.00
3_T 44_R 2.807 1.00
129_Q 132_E 2.735 1.00
226_A 240_R 2.568 1.00
74_D 197_E 2.507 1.00
48_V 206_A 2.324 1.00
58_L 80_S 2.279 1.00
239_I 242_A 2.225 1.00
130_P 151_L 2.181 1.00
268_V 275_A 2.046 0.99
182_S 209_L 1.991 0.99
237_R 246_E 1.986 0.99
282_R 285_E 1.939 0.99
135_A 139_A 1.906 0.99
142_W 153_R 1.884 0.98
6_V 36_L 1.871 0.98
119_Q 145_K 1.857 0.98
230_N 251_A 1.853 0.98
226_A 238_A 1.832 0.98
278_G 286_T 1.831 0.98
34_P 95_Q 1.814 0.98
241_H 296_S 1.802 0.98
285_E 290_E 1.757 0.97
214_N 273_K 1.753 0.97
37_A 92_L 1.748 0.97
229_E 251_A 1.745 0.97
274_P 294_C 1.725 0.97
243_T 246_E 1.716 0.97
109_E 162_K 1.701 0.97
159_Q 266_G 1.693 0.96
89_A 103_T 1.691 0.96
221_L 283_I 1.673 0.96
229_E 237_R 1.614 0.95
247_L 295_I 1.603 0.95
207_A 211_E 1.601 0.95
261_V 275_A 1.577 0.94
230_N 233_T 1.572 0.94
225_D 228_Y 1.57 0.94
246_E 249_P 1.565 0.94
219_V 283_I 1.564 0.94
208_L 212_Q 1.562 0.94
73_L 77_V 1.545 0.93
226_A 291_A 1.493 0.92
137_E 144_M 1.487 0.91
170_E 174_K 1.483 0.91
8_L 12_A 1.471 0.91
60_L 128_Y 1.456 0.90
171_L 175_E 1.444 0.90
182_S 205_A 1.441 0.90
134_E 138_A 1.429 0.89
123_F 253_A 1.412 0.88
75_V 87_M 1.404 0.88
253_A 258_G 1.389 0.87
128_Y 136_L 1.367 0.86
128_Y 144_M 1.364 0.86
162_K 166_S 1.363 0.86
57_L 61_Q 1.361 0.86
225_D 291_A 1.354 0.85
38_R 284_E 1.353 0.85
168_A 177_H 1.351 0.85
123_F 145_K 1.334 0.84
61_Q 83_M 1.333 0.84
159_Q 262_T 1.308 0.82
127_V 146_R 1.303 0.82
134_E 151_L 1.292 0.81
18_E 28_N 1.292 0.81
89_A 107_R 1.291 0.81
46_A 213_I 1.283 0.81
163_I 209_L 1.279 0.80
124_I 225_D 1.27 0.80
268_V 271_R 1.267 0.80
127_V 149_K 1.265 0.79
22_A 75_V 1.264 0.79
162_K 191_D 1.259 0.79
61_Q 79_E 1.249 0.78
22_A 87_M 1.247 0.78
62_N 79_E 1.232 0.77
169_I 182_S 1.232 0.77
207_A 266_G 1.22 0.76
123_F 127_V 1.218 0.76
109_E 164_L 1.21 0.75
116_A 124_I 1.207 0.75
107_R 164_L 1.204 0.75
264_V 268_V 1.195 0.74
217_G 276_W 1.194 0.74
254_D 258_G 1.192 0.73
276_W 286_T 1.186 0.73
248_A 262_T 1.185 0.73
219_V 276_W 1.174 0.72
57_L 62_N 1.17 0.72
211_E 266_G 1.169 0.71
46_A 173_L 1.164 0.71
278_G 291_A 1.159 0.70
230_N 237_R 1.15 0.70
22_A 61_Q 1.149 0.70
58_L 76_L 1.138 0.68
22_A 74_D 1.133 0.68
20_L 24_N 1.133 0.68
4_L 280_L 1.132 0.68
26_Y 91_S 1.129 0.68
162_K 212_Q 1.127 0.67
79_E 83_M 1.121 0.67
208_L 211_E 1.116 0.66
57_L 83_M 1.109 0.66
264_V 275_A 1.108 0.65
8_L 280_L 1.108 0.65
227_V 277_I 1.105 0.65
12_A 221_L 1.099 0.65
204_L 262_T 1.091 0.64
26_Y 90_Q 1.087 0.63
5_V 215_A 1.072 0.62
96_P 101_V 1.068 0.61
68_V 87_M 1.064 0.61
80_S 83_M 1.059 0.60
111_S 161_R 1.055 0.60
137_E 151_L 1.048 0.59
14_L 61_Q 1.047 0.59
4_L 43_Y 1.042 0.58
33_V 91_S 1.033 0.57
206_A 218_L 1.022 0.56
6_V 266_G 1.016 0.56
98_M 167_E 1.016 0.56
44_R 176_G 1.008 0.55
225_D 282_R 1.004 0.54
62_N 68_V 1.004 0.54
60_L 126_P 1.002 0.54
58_L 61_Q 1 0.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1e19A211000.497Contact Map0.729
2e9yA211000.499Contact Map0.688
4jz8A411000.511Contact Map0.769
4axsA10.97981000.52Contact Map0.607
2we5A30.98991000.527Contact Map0.717
2ap9A60.83841000.723Contact Map0.431
2bufA120.82151000.723Contact Map0.567
2btyA30.81821000.727Contact Map0.518
2rd5A20.84851000.728Contact Map0.465
3l86A10.78111000.73Contact Map0.429

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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