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ARSR - Arsenical resistance operon repressor
UniProt: P37309 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12235
Length: 117 (106)
Sequences: 1405
Seq/Len: 13.25

ARSR
Paralog alert: 0.36 [within 20: 0.09] - ratio of genomes with paralogs
Cluster includes: ARSR YGAV
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
30_E 63_R 3.83 1.00
61_L 74_S 2.387 1.00
62_D 69_V 2.22 1.00
64_K 69_V 2.21 1.00
4_L 16_E 2 1.00
35_D 38_T 1.988 1.00
20_G 99_I 1.854 1.00
33_V 51_L 1.836 1.00
52_A 56_E 1.824 1.00
8_Q 56_E 1.814 1.00
83_K 87_E 1.803 1.00
12_I 57_S 1.696 1.00
46_K 49_R 1.661 1.00
32_C 68_W 1.645 1.00
61_L 72_R 1.63 1.00
25_L 60_L 1.55 1.00
24_L 36_L 1.549 1.00
37_C 47_I 1.549 1.00
51_L 71_Y 1.517 1.00
3_F 20_G 1.498 1.00
42_Q 46_K 1.404 0.99
33_V 71_Y 1.39 0.99
43_S 46_K 1.352 0.99
101_R 104_A 1.34 0.99
7_I 14_A 1.309 0.99
63_R 72_R 1.3 0.99
24_L 31_L 1.294 0.99
79_A 83_K 1.28 0.99
52_A 55_R 1.251 0.99
43_S 50_H 1.244 0.98
48_S 71_Y 1.243 0.98
63_R 70_H 1.24 0.98
12_I 54_L 1.211 0.98
21_I 47_I 1.202 0.98
54_L 60_L 1.187 0.98
17_T 50_H 1.181 0.98
97_Q 100_V 1.157 0.97
7_I 19_L 1.153 0.97
10_F 15_D 1.153 0.97
65_Q 70_H 1.14 0.97
55_R 62_D 1.132 0.97
21_I 36_L 1.13 0.97
42_Q 47_I 1.127 0.97
13_L 22_V 1.104 0.96
31_L 39_A 1.081 0.95
2_S 5_L 1.066 0.95
22_V 73_L 1.065 0.95
35_D 70_H 1.033 0.94
62_D 71_Y 1.023 0.93
34_C 68_W 1.014 0.93
32_C 70_H 1.008 0.93
97_Q 104_A 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1u2wA40.820599.60.514Contact Map0.819
3f6vA10.931699.60.519Contact Map0.739
1r1tA20.786399.60.524Contact Map0.844
2kkoA20.837699.60.529Contact Map0.723
2zkzA40.752199.60.535Contact Map0.796
4g6qA20.991599.60.536Contact Map0.716
3pqkA60.81299.50.543Contact Map0.824
1q1hA10.863299.50.546Contact Map0.462
3jthA20.777899.50.551Contact Map0.843
3cuoA40.777899.50.551Contact Map0.805

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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