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CSIR - HTH-type transcriptional repressor CsiR
UniProt: P37338 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12386
Length: 220 (208)
Sequences: 9960
Seq/Len: 47.88

CSIR
Paralog alert: 0.80 [within 20: 0.20] - ratio of genomes with paralogs
Cluster includes: CSIR DGOR EXUR FADR GLCC LLDR MCBR NANR PDHR UXUR YDFH YIEP
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
105_L 191_L 4.189 1.00
90_S 199_S 3.323 1.00
22_Q 25_E 3.149 1.00
194_D 197_R 3.147 1.00
112_S 184_Q 2.929 1.00
15_D 35_R 2.627 1.00
15_D 20_N 2.612 1.00
76_D 145_H 2.534 1.00
83_N 87_M 2.33 1.00
9_Y 49_Q 2.302 1.00
29_M 40_V 2.227 1.00
13_K 53_E 2.126 1.00
8_G 38_L 2.085 1.00
97_G 100_W 2.067 1.00
8_G 36_Y 2.046 1.00
82_A 207_L 2.037 1.00
189_A 197_R 1.988 1.00
94_A 195_T 1.903 1.00
100_W 143_G 1.866 1.00
197_R 201_L 1.864 1.00
103_D 137_A 1.815 1.00
123_M 126_E 1.799 1.00
79_D 91_L 1.797 1.00
101_E 191_L 1.779 1.00
58_V 64_Y 1.768 1.00
57_T 67_A 1.7 1.00
137_A 140_A 1.619 1.00
11_W 15_D 1.605 1.00
135_H 183_H 1.597 1.00
14_N 18_R 1.594 1.00
140_A 148_L 1.58 1.00
188_A 192_A 1.573 1.00
90_S 196_A 1.557 1.00
199_S 203_R 1.544 1.00
80_A 150_M 1.516 1.00
136_T 152_E 1.513 1.00
32_L 43_L 1.507 1.00
86_A 199_S 1.506 1.00
108_A 187_T 1.486 1.00
9_Y 53_E 1.466 1.00
200_E 204_Q 1.435 1.00
192_A 197_R 1.416 1.00
107_K 130_R 1.409 1.00
59_V 62_K 1.401 0.99
86_A 203_R 1.383 0.99
184_Q 188_A 1.38 0.99
182_Q 205_H 1.373 0.99
89_V 202_M 1.37 0.99
87_M 90_S 1.352 0.99
90_S 195_T 1.35 0.99
89_V 93_I 1.349 0.99
138_I 190_V 1.328 0.99
76_D 146_Y 1.317 0.99
31_L 35_R 1.315 0.99
100_W 141_G 1.31 0.99
11_W 14_N 1.298 0.99
197_R 200_E 1.295 0.99
195_T 199_S 1.292 0.99
110_L 133_A 1.29 0.99
149_Q 153_R 1.274 0.99
81_R 85_E 1.273 0.99
96_G 101_E 1.27 0.99
28_R 31_L 1.265 0.99
96_G 193_R 1.263 0.99
139_V 151_R 1.26 0.99
82_A 203_R 1.251 0.99
82_A 86_A 1.24 0.98
142_C 148_L 1.237 0.98
185_T 201_L 1.235 0.98
89_V 198_A 1.228 0.98
182_Q 208_T 1.226 0.98
131_H 135_H 1.224 0.98
106_A 110_L 1.215 0.98
76_D 144_S 1.188 0.98
30_S 34_S 1.182 0.98
133_A 137_A 1.177 0.98
105_L 109_H 1.176 0.98
103_D 140_A 1.174 0.98
96_G 190_V 1.171 0.98
96_G 141_G 1.164 0.97
15_D 36_Y 1.163 0.97
88_L 139_V 1.161 0.97
79_D 95_R 1.158 0.97
51_V 56_V 1.149 0.97
86_A 90_S 1.14 0.97
187_T 191_L 1.139 0.97
59_V 65_R 1.134 0.97
186_L 201_L 1.131 0.97
11_W 36_Y 1.128 0.97
47_L 56_V 1.124 0.97
7_D 11_W 1.118 0.96
186_L 202_M 1.114 0.96
16_I 66_V 1.111 0.96
189_A 194_D 1.109 0.96
79_D 144_S 1.106 0.96
137_A 141_G 1.104 0.96
96_G 100_W 1.099 0.96
51_V 58_V 1.099 0.96
110_L 130_R 1.095 0.96
109_H 113_K 1.093 0.96
105_L 187_T 1.079 0.95
101_E 187_T 1.079 0.95
82_A 210_I 1.079 0.95
185_T 197_R 1.079 0.95
146_Y 157_L 1.066 0.95
98_D 193_R 1.05 0.94
101_E 193_R 1.049 0.94
136_T 140_A 1.039 0.94
45_E 48_S 1.033 0.94
185_T 204_Q 1.029 0.94
56_V 64_Y 1.028 0.94
93_I 195_T 1.027 0.94
129_L 133_A 1.027 0.94
109_H 112_S 1.022 0.93
134_F 187_T 1.019 0.93
183_H 205_H 1.017 0.93
107_K 137_A 1.016 0.93
62_K 65_R 1.014 0.93
196_A 200_E 1.007 0.93
203_R 207_L 1.003 0.93
26_K 65_R 1.003 0.93
13_K 55_L 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3c7jA20.951000.128Contact Map0.792
2hs5A10.95451000.129Contact Map0.592
3sxyA20.93181000.135Contact Map0.769
3ihuA20.94551000.137Contact Map0.645
2di3A20.96361000.163Contact Map0.654
1hw1A20.93641000.2Contact Map0.648
4hamA10.540999.90.528Contact Map0.702
3ic7A20.518299.80.547Contact Map0.647
3by6A50.527399.80.55Contact Map0.837
3neuA10.509199.80.567Contact Map0.662

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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