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ATZN - Lead, cadmium, zinc and mercury-transporting ATPase
UniProt: P37617 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12215
Length: 732 (683)
Sequences: 6295
Seq/Len: 9.22

ATZN
Paralog alert: 0.83 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: ATKB ATMA ATZN COPA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
587_P 591_A 5.245 1.00
469_V 508_A 4.276 1.00
274_K 316_E 4.127 1.00
160_T 195_L 4.06 1.00
280_A 313_V 3.98 1.00
513_E 548_N 3.944 1.00
499_R 507_E 3.701 1.00
547_R 552_L 3.544 1.00
613_A 616_E 3.468 1.00
609_D 612_K 3.462 1.00
583_T 590_A 3.448 1.00
587_P 604_G 3.386 1.00
564_D 664_H 3.316 1.00
431_T 621_A 3.22 1.00
578_K 600_E 3.21 1.00
450_A 540_Q 3.089 1.00
430_V 624_A 3.078 1.00
277_S 314_T 3.015 1.00
280_A 308_S 2.999 1.00
260_V 314_T 2.952 1.00
468_A 493_P 2.949 1.00
462_L 553_G 2.949 1.00
497_S 509_Q 2.941 1.00
260_V 276_L 2.86 1.00
269_L 282_F 2.801 1.00
459_E 488_A 2.784 1.00
594_A 601_F 2.782 1.00
238_T 249_E 2.776 1.00
240_T 249_E 2.75 1.00
241_R 248_E 2.742 1.00
448_V 555_I 2.724 1.00
260_V 316_E 2.713 1.00
624_A 643_I 2.707 1.00
243_R 248_E 2.652 1.00
302_V 315_L 2.596 1.00
271_A 317_V 2.585 1.00
615_T 638_A 2.556 1.00
566_A 570_S 2.533 1.00
275_L 313_V 2.531 1.00
591_A 595_G 2.506 1.00
484_E 488_A 2.439 1.00
602_K 613_A 2.438 1.00
507_E 514_R 2.382 1.00
242_L 314_T 2.364 1.00
441_L 597_L 2.344 1.00
618_N 638_A 2.342 1.00
448_V 484_E 2.309 1.00
443_V 560_T 2.308 1.00
501_L 522_K 2.287 1.00
443_V 563_A 2.28 1.00
515_V 547_R 2.227 1.00
531_L 534_E 2.184 1.00
578_K 621_A 2.182 1.00
458_S 461_E 2.177 1.00
411_A 674_L 2.172 1.00
465_L 515_V 2.169 1.00
240_T 267_G 2.131 1.00
276_L 316_E 2.109 1.00
681_N 727_R 2.105 1.00
523_H 546_V 2.103 1.00
255_L 271_A 2.097 1.00
542_V 554_V 2.083 1.00
513_E 547_R 2.072 1.00
169_R 173_R 2.036 1.00
570_S 574_A 2.013 1.00
434_A 617_L 2.001 1.00
567_T 666_R 1.989 1.00
431_T 622_P 1.983 1.00
434_A 614_V 1.976 1.00
59_C 62_C 1.969 1.00
612_K 615_T 1.965 1.00
241_R 250_V 1.963 1.00
575_L 673_E 1.962 1.00
275_L 282_F 1.953 1.00
517_I 545_V 1.95 1.00
532_I 544_L 1.941 1.00
571_E 673_E 1.937 1.00
616_E 619_Q 1.937 1.00
591_A 601_F 1.933 1.00
582_L 613_A 1.919 1.00
192_I 196_F 1.873 1.00
484_E 487_V 1.866 1.00
273_G 315_L 1.86 1.00
581_I 590_A 1.857 1.00
434_A 582_L 1.853 1.00
297_A 300_D 1.847 1.00
349_R 353_I 1.84 1.00
284_E 296_R 1.828 1.00
467_A 485_A 1.81 1.00
647_S 663_N 1.805 1.00
545_V 553_G 1.801 1.00
573_N 579_G 1.788 1.00
241_R 259_D 1.784 1.00
360_A 364_L 1.773 1.00
255_L 261_I 1.757 1.00
687_T 691_G 1.753 1.00
243_R 246_E 1.742 1.00
283_D 309_V 1.732 1.00
568_A 669_V 1.723 1.00
561_L 597_L 1.72 1.00
432_Q 580_V 1.714 1.00
516_L 546_V 1.709 1.00
449_T 540_Q 1.708 1.00
331_K 335_E 1.707 1.00
543_V 557_L 1.705 1.00
403_A 725_A 1.702 1.00
507_E 516_L 1.697 1.00
139_A 208_L 1.696 1.00
435_F 441_L 1.695 1.00
365_V 383_K 1.694 1.00
55_S 110_S 1.691 1.00
643_I 668_L 1.681 1.00
509_Q 514_R 1.674 1.00
168_A 192_I 1.673 1.00
433_V 624_A 1.657 1.00
317_V 320_E 1.655 1.00
282_F 313_V 1.641 1.00
414_R 670_Q 1.639 1.00
519_A 522_K 1.635 1.00
432_Q 621_A 1.631 1.00
464_T 511_N 1.627 1.00
258_G 316_E 1.618 1.00
63_A 83_F 1.615 1.00
684_Q 724_N 1.604 1.00
566_A 596_E 1.599 1.00
583_T 603_A 1.598 1.00
262_E 314_T 1.593 1.00
534_E 538_A 1.592 1.00
580_V 600_E 1.586 1.00
466_A 545_V 1.586 1.00
569_I 579_G 1.581 1.00
461_E 464_T 1.58 1.00
564_D 666_R 1.572 1.00
481_I 555_I 1.565 1.00
274_K 318_L 1.563 1.00
441_L 561_L 1.563 1.00
243_R 259_D 1.554 1.00
275_L 278_P 1.549 1.00
457_I 552_L 1.536 1.00
263_V 315_L 1.532 1.00
515_V 552_L 1.531 1.00
474_T 500_A 1.53 1.00
261_I 315_L 1.527 1.00
681_N 725_A 1.526 1.00
407_G 678_T 1.523 1.00
410_A 414_R 1.522 1.00
612_K 616_E 1.518 1.00
446_P 477_L 1.518 1.00
70_V 88_L 1.517 1.00
443_V 447_R 1.495 1.00
516_L 522_K 1.49 1.00
168_A 188_S 1.486 1.00
468_A 492_I 1.485 1.00
479_Q 483_R 1.482 1.00
498_Q 506_I 1.48 1.00
724_N 727_R 1.478 1.00
470_E 478_A 1.476 1.00
447_R 483_R 1.474 1.00
611_V 638_A 1.471 1.00
501_L 507_E 1.47 1.00
429_R 622_P 1.463 1.00
561_L 593_I 1.453 1.00
418_I 658_A 1.45 1.00
188_S 192_I 1.447 1.00
403_A 681_N 1.447 1.00
78_Q 91_D 1.441 1.00
321_P 324_S 1.44 1.00
247_R 262_E 1.435 0.99
590_A 601_F 1.429 0.99
274_K 299_G 1.422 0.99
544_L 551_V 1.42 0.99
102_S 106_K 1.413 0.99
279_F 297_A 1.41 0.99
567_T 571_E 1.403 0.99
279_F 295_E 1.402 0.99
281_S 295_E 1.381 0.99
328_R 608_E 1.379 0.99
496_E 509_Q 1.379 0.99
460_S 488_A 1.377 0.99
457_I 462_L 1.377 0.99
444_G 559_D 1.368 0.99
189_V 359_M 1.368 0.99
535_L 556_A 1.367 0.99
575_L 676_R 1.362 0.99
163_G 168_A 1.361 0.99
469_V 515_V 1.359 0.99
662_H 667_G 1.356 0.99
103_A 107_A 1.346 0.99
239_A 270_P 1.341 0.99
301_K 319_S 1.341 0.99
136_V 208_L 1.327 0.99
312_L 472_G 1.319 0.99
602_K 616_E 1.316 0.99
274_K 301_K 1.313 0.99
469_V 506_I 1.31 0.99
466_A 517_I 1.31 0.99
435_F 579_G 1.306 0.99
464_T 493_P 1.303 0.99
469_V 517_I 1.301 0.99
301_K 318_L 1.299 0.99
681_N 684_Q 1.299 0.99
449_T 558_Q 1.29 0.99
242_L 247_R 1.289 0.99
435_F 668_L 1.284 0.99
493_P 511_N 1.283 0.99
265_A 280_A 1.276 0.99
637_K 655_T 1.275 0.99
679_H 683_R 1.271 0.98
510_V 515_V 1.263 0.98
569_I 573_N 1.257 0.98
366_T 384_G 1.256 0.98
448_V 557_L 1.248 0.98
261_I 317_V 1.248 0.98
172_L 176_K 1.247 0.98
287_L 303_P 1.246 0.98
219_W 223_R 1.241 0.98
452_H 535_L 1.239 0.98
582_L 605_L 1.236 0.98
427_L 671_M 1.235 0.98
644_A 656_A 1.233 0.98
71_R 79_V 1.232 0.98
447_R 560_T 1.23 0.98
594_A 599_L 1.226 0.98
501_L 504_S 1.219 0.98
250_V 254_S 1.215 0.98
240_T 247_R 1.215 0.98
361_V 701_L 1.214 0.98
81_V 88_L 1.213 0.98
471_Q 486_Q 1.21 0.98
516_L 523_H 1.203 0.98
242_L 262_E 1.196 0.97
73_L 103_A 1.195 0.97
286_A 306_A 1.194 0.97
450_A 459_E 1.191 0.97
251_A 254_S 1.184 0.97
265_A 500_A 1.184 0.97
540_Q 556_A 1.179 0.97
451_I 555_I 1.178 0.97
618_N 640_A 1.177 0.97
570_S 573_N 1.176 0.97
67_E 71_R 1.175 0.97
431_T 620_H 1.175 0.97
366_T 369_P 1.173 0.97
565_A 569_I 1.173 0.97
464_T 468_A 1.172 0.97
608_E 612_K 1.171 0.97
277_S 298_T 1.166 0.97
435_F 572_L 1.163 0.97
70_V 79_V 1.158 0.97
468_A 495_A 1.158 0.97
466_A 555_I 1.156 0.97
520_A 544_L 1.156 0.97
571_E 574_A 1.153 0.97
137_M 141_S 1.151 0.97
420_G 657_D 1.151 0.97
587_P 601_F 1.15 0.97
131_L 166_P 1.149 0.97
453_P 462_L 1.142 0.96
66_V 107_A 1.139 0.96
483_R 486_Q 1.132 0.96
410_A 413_R 1.131 0.96
474_T 498_Q 1.13 0.96
581_I 599_L 1.127 0.96
76_V 100_V 1.127 0.96
453_P 553_G 1.125 0.96
255_L 317_V 1.122 0.96
587_P 603_A 1.122 0.96
353_I 357_A 1.121 0.96
504_S 606_L 1.118 0.96
495_A 508_A 1.118 0.96
672_I 676_R 1.117 0.96
261_I 270_P 1.117 0.96
575_L 672_I 1.111 0.96
484_E 490_L 1.11 0.96
257_P 320_E 1.11 0.96
535_L 540_Q 1.106 0.96
262_E 312_L 1.104 0.95
275_L 280_A 1.1 0.95
138_M 141_S 1.099 0.95
529_T 533_N 1.098 0.95
564_D 567_T 1.098 0.95
367_L 371_L 1.097 0.95
564_D 568_A 1.094 0.95
191_A 207_L 1.09 0.95
240_T 264_A 1.085 0.95
590_A 603_A 1.083 0.95
496_E 512_G 1.08 0.95
583_T 601_F 1.08 0.95
304_A 324_S 1.078 0.95
390_I 696_F 1.077 0.95
275_L 300_D 1.077 0.95
54_V 57_M 1.076 0.95
645_M 648_G 1.076 0.95
450_A 535_L 1.076 0.95
515_V 545_V 1.076 0.95
265_A 308_S 1.075 0.95
469_V 545_V 1.071 0.94
426_Q 640_A 1.071 0.94
302_V 313_V 1.068 0.94
428_G 679_H 1.065 0.94
291_S 589_A 1.064 0.94
582_L 602_K 1.063 0.94
242_L 260_V 1.061 0.94
303_P 306_A 1.059 0.94
495_A 510_V 1.059 0.94
462_L 545_V 1.057 0.94
518_C 522_K 1.056 0.94
426_Q 429_R 1.051 0.94
571_E 575_L 1.051 0.94
427_L 641_I 1.05 0.94
449_T 535_L 1.047 0.93
206_V 711_V 1.044 0.93
70_V 100_V 1.036 0.93
615_T 618_N 1.036 0.93
447_R 487_V 1.031 0.93
57_M 62_C 1.03 0.93
71_R 78_Q 1.029 0.93
680_A 684_Q 1.027 0.93
51_S 87_K 1.027 0.93
263_V 269_L 1.026 0.93
602_K 605_L 1.024 0.92
265_A 474_T 1.021 0.92
101_E 105_Q 1.019 0.92
364_L 368_V 1.018 0.92
132_I 136_V 1.017 0.92
428_G 675_A 1.016 0.92
714_D 717_A 1.015 0.92
102_S 105_Q 1.015 0.92
156_F 199_A 1.014 0.92
224_A 409_A 1.014 0.92
418_I 671_M 1.013 0.92
711_V 715_T 1.013 0.92
241_R 261_I 1.01 0.92
163_G 192_I 1.009 0.92
345_R 349_R 1.008 0.92
230_A 413_R 1.007 0.92
461_E 513_E 1.002 0.91
483_R 487_V 1.001 0.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3j09A20.9291000.264Contact Map0.716
3rfuA40.92621000.269Contact Map0.648
3j08A20.82511000.333Contact Map0.674
3b8cA20.83881000.505Contact Map0.525
1mhsA20.90571000.51Contact Map0.511
3ar4A10.81971000.541Contact Map0.696
2zxeA10.88251000.543Contact Map0.664
3ixzA10.90981000.545Contact Map0.078
3skxA10.37841000.782Contact Map0.768
3a1cA20.38251000.799Contact Map0.804

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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