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ACPT - 4'-phosphopantetheinyl transferase AcpT
UniProt: P37623 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12221
Length: 195 (173)
Sequences: 284
Seq/Len: 1.64

ACPT
Paralog alert: 0.10 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: ACPT YIEE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
135_R 163_V 2.628 1.00
93_E 134_T 2.226 0.99
74_S 93_E 1.79 0.96
139_I 163_V 1.779 0.96
17_L 22_R 1.692 0.94
139_I 143_R 1.683 0.94
30_R 146_S 1.626 0.93
82_L 105_A 1.609 0.92
18_P 24_Q 1.607 0.92
57_G 175_I 1.556 0.90
58_K 68_W 1.55 0.90
79_A 173_L 1.548 0.90
81_L 90_C 1.529 0.89
27_Q 30_R 1.515 0.89
19_P 23_E 1.479 0.87
79_A 90_C 1.476 0.87
92_I 171_L 1.424 0.84
115_A 119_A 1.392 0.82
30_R 33_R 1.389 0.82
14_A 92_I 1.369 0.81
81_L 88_V 1.365 0.80
47_P 88_V 1.325 0.78
36_A 51_I 1.307 0.76
88_V 96_R 1.291 0.75
34_W 70_N 1.29 0.75
83_S 176_C 1.275 0.74
83_S 179_T 1.273 0.73
88_V 168_L 1.268 0.73
29_P 33_R 1.262 0.73
105_A 108_V 1.258 0.72
69_F 129_F 1.245 0.71
41_L 69_F 1.227 0.69
30_R 78_I 1.221 0.69
62_A 71_L 1.221 0.69
113_E 136_K 1.217 0.69
181_F 185_A 1.209 0.68
17_L 21_L 1.193 0.66
106_N 117_M 1.182 0.65
33_R 75_G 1.178 0.65
134_T 165_H 1.175 0.65
21_L 26_P 1.171 0.64
142_Q 161_L 1.162 0.63
182_T 186_D 1.159 0.63
161_L 176_C 1.157 0.63
78_I 107_A 1.156 0.63
16_P 22_R 1.149 0.62
37_G 69_F 1.147 0.62
117_M 120_V 1.14 0.61
109_F 129_F 1.125 0.60
14_A 23_E 1.116 0.59
52_I 70_N 1.113 0.58
88_V 94_V 1.111 0.58
39_A 82_L 1.104 0.57
131_R 163_V 1.101 0.57
58_K 70_N 1.097 0.57
61_F 174_A 1.095 0.57
109_F 140_V 1.09 0.56
106_N 175_I 1.09 0.56
182_T 185_A 1.085 0.56
58_K 111_L 1.085 0.56
109_F 176_C 1.084 0.55
65_M 90_C 1.083 0.55
132_I 175_I 1.081 0.55
55_E 90_C 1.075 0.54
15_A 22_R 1.075 0.54
183_L 186_D 1.074 0.54
67_L 82_L 1.073 0.54
34_W 38_R 1.07 0.54
42_S 51_I 1.067 0.54
49_P 180_P 1.066 0.54
51_I 82_L 1.064 0.53
34_W 139_I 1.054 0.52
140_V 145_G 1.052 0.52
134_T 174_A 1.052 0.52
110_S 142_Q 1.05 0.52
102_R 138_A 1.05 0.52
124_Q 162_S 1.047 0.52
35_L 79_A 1.042 0.51
63_P 111_L 1.037 0.50
125_Q 174_A 1.037 0.50
16_P 20_G 1.027 0.49
15_A 19_P 1.026 0.49
49_P 84_D 1.023 0.49
181_F 184_T 1.017 0.48
46_S 49_P 1.016 0.48
78_I 132_I 1.016 0.48
40_L 109_F 1.007 0.47
72_S 150_I 1.004 0.47
93_E 108_V 1.004 0.47
25_A 35_L 1.001 0.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2c43A10.99491000.392Contact Map0.359
1qr0A10.98461000.409Contact Map0.388
3f09A30.630899.90.637Contact Map0.396
1fthA30.523199.50.734Contact Map0.4
3hykA30.523199.50.735Contact Map0.455
2wasA30.487299.50.737Contact Map0.421
1f7lA10.512899.50.742Contact Map0.392
2wdsA10.584699.50.749Contact Map0.455
3h88A240.507799.40.751Contact Map0.339
3nfdA60.517999.40.752Contact Map0.399

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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