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BCSQ - Putative cellulose biosynthesis protein BcsQ
UniProt: P37655 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12261
Length: 250 (239)
Sequences: 8981
Seq/Len: 37.58

BCSQ
Paralog alert: 0.85 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: BCSQ MIND
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
19_T 122_L 4.375 1.00
80_D 118_Y 4.197 1.00
200_H 227_E 3.898 1.00
29_L 233_N 3.416 1.00
18_I 228_I 3.249 1.00
5_G 140_C 3.081 1.00
26_L 120_W 3.008 1.00
31_E 120_W 2.851 1.00
214_P 217_E 2.71 1.00
34_L 118_Y 2.675 1.00
28_M 229_L 2.665 1.00
148_N 172_D 2.501 1.00
19_T 35_V 2.454 1.00
35_V 44_L 2.446 1.00
2_A 142_H 2.43 1.00
172_D 201_R 2.226 1.00
6_L 22_L 2.213 1.00
20_A 44_L 2.204 1.00
18_I 169_L 2.133 1.00
185_Q 189_Q 2.116 1.00
197_M 234_W 2.07 1.00
32_N 119_Q 2.066 1.00
169_L 231_L 2.011 1.00
74_R 80_D 1.979 1.00
23_A 35_V 1.944 1.00
26_L 122_L 1.909 1.00
23_A 122_L 1.888 1.00
25_S 232_A 1.872 1.00
29_L 229_L 1.835 1.00
197_M 231_L 1.814 1.00
204_A 207_E 1.798 1.00
22_L 232_A 1.715 1.00
25_S 216_G 1.694 1.00
47_S 152_N 1.677 1.00
22_L 235_C 1.644 1.00
174_R 201_R 1.638 1.00
20_A 47_S 1.638 1.00
222_A 225_A 1.637 1.00
31_E 119_Q 1.575 1.00
69_R 117_R 1.562 1.00
46_L 155_I 1.558 1.00
6_L 144_L 1.555 1.00
18_I 171_N 1.529 1.00
6_L 19_T 1.524 1.00
23_A 44_L 1.517 1.00
196_P 234_W 1.507 1.00
170_I 184_Y 1.49 1.00
5_G 125_L 1.477 1.00
226_E 229_L 1.473 1.00
27_Q 78_Q 1.45 1.00
48_F 79_L 1.446 1.00
57_G 60_R 1.393 0.99
27_Q 79_L 1.389 0.99
31_E 236_L 1.377 0.99
207_E 211_A 1.36 0.99
14_G 171_N 1.358 0.99
219_R 222_A 1.355 0.99
29_L 236_L 1.351 0.99
186_L 189_Q 1.329 0.99
3_V 123_I 1.326 0.99
230_T 233_N 1.323 0.99
67_D 70_D 1.313 0.99
142_H 166_A 1.309 0.99
142_H 167_H 1.301 0.99
80_D 116_G 1.282 0.99
34_L 121_I 1.282 0.99
68_W 82_L 1.265 0.99
38_A 123_I 1.257 0.99
213_Q 217_E 1.251 0.99
43_L 156_R 1.247 0.99
43_L 152_N 1.24 0.98
144_L 169_L 1.234 0.98
205_M 224_A 1.234 0.98
58_W 61_A 1.233 0.98
2_A 141_D 1.232 0.98
173_F 198_L 1.226 0.98
233_N 237_L 1.221 0.98
152_N 209_L 1.214 0.98
38_A 136_L 1.199 0.98
81_L 86_Q 1.198 0.98
184_Y 198_L 1.197 0.98
50_V 81_L 1.193 0.98
202_D 224_A 1.177 0.98
20_A 48_F 1.167 0.97
56_Q 60_R 1.166 0.97
106_C 110_Q 1.165 0.97
149_V 170_I 1.165 0.97
7_Q 125_L 1.164 0.97
223_L 226_E 1.155 0.97
26_L 33_V 1.155 0.97
179_V 183_I 1.141 0.97
231_L 235_C 1.14 0.97
220_S 225_A 1.12 0.96
177_S 180_Q 1.109 0.96
3_V 121_I 1.107 0.96
150_D 153_C 1.105 0.96
110_Q 113_K 1.101 0.96
171_N 228_I 1.099 0.96
202_D 222_A 1.093 0.96
203_E 207_E 1.09 0.96
186_L 190_S 1.085 0.96
227_E 230_T 1.081 0.95
36_V 121_I 1.078 0.95
26_L 232_A 1.074 0.95
18_I 22_L 1.067 0.95
114_A 117_R 1.059 0.95
6_L 18_I 1.056 0.95
107_S 111_Q 1.055 0.95
32_N 117_R 1.054 0.95
38_A 58_W 1.053 0.95
33_V 119_Q 1.048 0.94
10_R 15_T 1.044 0.94
72_G 80_D 1.032 0.94
195_L 198_L 1.03 0.94
230_T 234_W 1.027 0.94
158_H 190_S 1.021 0.93
184_Y 188_L 1.014 0.93
204_A 219_R 1.014 0.93
6_L 122_L 1.009 0.93
199_I 227_E 1.003 0.93
23_A 79_L 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3pg5A411000.252Contact Map0.736
1wcv110.9521000.26Contact Map0.796
1g3qA10.9041000.275Contact Map0.808
1hyqA10.9481000.279Contact Map0.77
3ez9A20.9721000.287Contact Map0.613
3ez2A20.9641000.289Contact Map0.681
3ea0A20.8921000.293Contact Map0.817
3kjhA10.9121000.293Contact Map0.565
2ozeA10.9641000.296Contact Map0.603
3endA20.9361000.299Contact Map0.712

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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