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YIAV - Inner membrane protein YiaV
UniProt: P37683 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12290
Length: 378 (332)
Sequences: 3754
Seq/Len: 11.31

YIAV
Paralog alert: 0.75 [within 20: 0.08] - ratio of genomes with paralogs
Cluster includes: AAEA ACRA ACRE EMRA EMRK MACA MDTA MDTE MDTN YBHG YDHJ YHII YIAV YIBH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
86_K 227_D 5.031 1.00
76_E 93_R 4.324 1.00
103_V 210_L 4.076 1.00
292_G 328_I 3.909 1.00
90_V 221_I 3.776 1.00
149_A 168_R 3.44 1.00
107_M 214_K 3.192 1.00
86_K 89_E 2.968 1.00
110_I 203_I 2.904 1.00
277_D 291_S 2.787 1.00
114_E 207_K 2.73 1.00
295_A 329_E 2.718 1.00
96_P 100_Q 2.708 1.00
131_T 178_V 2.586 1.00
293_K 331_D 2.541 1.00
149_A 155_K 2.522 1.00
272_L 349_V 2.518 1.00
135_K 182_A 2.512 1.00
272_L 294_L 2.401 1.00
93_R 221_I 2.312 1.00
293_K 329_E 2.306 1.00
142_A 175_E 2.265 1.00
78_T 93_R 2.226 1.00
83_T 89_E 2.188 1.00
142_A 146_Q 2.164 1.00
87_K 227_D 2.14 1.00
264_F 272_L 2.079 1.00
277_D 293_K 2.077 1.00
90_V 223_R 2.043 1.00
154_A 164_I 2.015 1.00
291_S 331_D 1.997 1.00
145_Y 149_A 1.975 1.00
78_T 90_V 1.966 1.00
103_V 214_K 1.953 1.00
204_A 207_K 1.953 1.00
214_K 218_E 1.945 1.00
145_Y 171_Y 1.943 1.00
104_D 107_M 1.904 1.00
125_D 128_A 1.901 1.00
121_G 200_H 1.89 1.00
132_Q 135_K 1.857 1.00
100_Q 217_L 1.841 1.00
211_A 214_K 1.837 1.00
148_Y 159_F 1.825 1.00
131_T 185_Q 1.813 1.00
279_E 291_S 1.792 1.00
163_D 166_V 1.77 1.00
148_Y 167_A 1.753 1.00
224_A 252_F 1.751 1.00
228_G 252_F 1.748 1.00
138_R 171_Y 1.746 1.00
110_I 210_L 1.71 1.00
168_R 172_L 1.71 1.00
138_R 142_A 1.687 1.00
100_Q 104_D 1.682 1.00
171_Y 175_E 1.651 1.00
111_V 114_E 1.644 1.00
92_F 222_V 1.637 1.00
128_A 189_Q 1.628 1.00
142_A 171_Y 1.61 1.00
179_K 182_A 1.607 1.00
135_K 139_D 1.604 1.00
260_I 345_A 1.602 1.00
66_V 250_M 1.585 1.00
146_Q 149_A 1.582 1.00
282_F 345_A 1.573 1.00
324_V 343_I 1.57 1.00
164_I 168_R 1.559 1.00
84_L 229_Y 1.553 1.00
278_A 328_I 1.538 1.00
262_A 328_I 1.523 1.00
121_G 196_V 1.518 1.00
69_Q 219_Q 1.512 1.00
91_L 250_M 1.508 1.00
84_L 255_D 1.493 1.00
102_R 212_E 1.481 1.00
103_V 107_M 1.478 1.00
99_Y 220_T 1.476 1.00
75_I 93_R 1.476 1.00
74_V 92_F 1.472 1.00
280_V 345_A 1.47 1.00
212_E 216_N 1.457 1.00
279_E 289_V 1.453 1.00
72_G 94_L 1.444 1.00
280_V 330_L 1.442 1.00
105_R 209_Q 1.432 1.00
242_A 247_R 1.43 1.00
140_K 144_E 1.424 1.00
145_Y 164_I 1.41 1.00
145_Y 168_R 1.41 1.00
264_F 349_V 1.389 0.99
80_K 83_T 1.388 0.99
110_I 114_E 1.38 0.99
175_E 179_K 1.374 0.99
278_A 347_V 1.364 0.99
280_V 347_V 1.32 0.99
75_I 95_D 1.308 0.99
215_Y 219_Q 1.298 0.99
76_E 237_P 1.298 0.99
281_V 348_A 1.286 0.99
103_V 217_L 1.278 0.99
261_V 327_T 1.276 0.99
107_M 210_L 1.275 0.99
128_A 185_Q 1.254 0.99
139_D 143_K 1.245 0.98
131_T 135_K 1.237 0.98
186_K 189_Q 1.237 0.98
139_D 142_A 1.237 0.98
294_L 326_A 1.224 0.98
60_A 261_V 1.216 0.98
117_Q 203_I 1.213 0.98
117_Q 200_H 1.197 0.98
138_R 175_E 1.187 0.98
106_L 206_L 1.164 0.97
154_A 161_E 1.15 0.97
77_V 237_P 1.146 0.97
114_E 203_I 1.145 0.97
109_D 202_Q 1.131 0.97
74_V 77_V 1.131 0.97
197_L 200_H 1.129 0.97
115_H 201_S 1.125 0.97
118_R 121_G 1.114 0.96
92_F 249_V 1.11 0.96
265_R 268_S 1.108 0.96
144_E 166_V 1.108 0.96
108_A 208_A 1.1 0.96
207_K 211_A 1.098 0.96
161_E 165_D 1.095 0.96
278_A 292_G 1.092 0.96
61_V 259_Q 1.092 0.96
119_A 195_L 1.091 0.96
82_N 296_A 1.09 0.96
69_Q 73_V 1.076 0.95
131_T 182_A 1.073 0.95
110_I 207_K 1.068 0.95
185_Q 189_Q 1.062 0.95
117_Q 121_G 1.058 0.95
90_V 93_R 1.058 0.95
78_T 89_E 1.054 0.95
109_D 205_S 1.053 0.95
57_A 61_V 1.053 0.95
147_R 165_D 1.052 0.95
178_V 182_A 1.051 0.94
241_A 249_V 1.046 0.94
85_I 91_L 1.04 0.94
102_R 216_N 1.035 0.94
62_I 259_Q 1.027 0.94
270_L 286_P 1.026 0.94
172_L 175_E 1.02 0.93
109_D 113_A 1.018 0.93
141_F 174_Q 1.016 0.93
113_A 117_Q 1.01 0.93
104_D 211_A 1.009 0.93
102_R 105_R 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4dk0A10.81221000.504Contact Map0.63
3fppA20.77511000.507Contact Map0.736
3lnnA20.78841000.53Contact Map0.713
2f1mA40.69051000.546Contact Map0.682
4l8jA10.70631000.559Contact Map0.727
1vf7A130.72491000.561Contact Map0.752
3ne5B20.75661000.596Contact Map0.766
4kkuA40.59521000.64Contact Map0.773
2k32A10.304299.90.737Contact Map0.673
2dneA10.267299.50.804Contact Map0.664

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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