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ALDB - Aldehyde dehydrogenase B
UniProt: P37685 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12292
Length: 512 (471)
Sequences: 15867
Seq/Len: 33.69

ALDB
Paralog alert: 0.74 [within 20: 0.21] - ratio of genomes with paralogs
Cluster includes: ABDH ALDA ALDB ASTD BETB EUTE FEAB GABD PROA PUUC SAD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
317_E 420_K 5.332 1.00
256_Q 260_Q 3.76 1.00
317_E 418_T 3.177 1.00
290_D 326_R 3.144 1.00
352_H 356_E 2.867 1.00
285_E 316_Q 2.852 1.00
399_Q 402_M 2.83 1.00
72_H 238_R 2.826 1.00
43_Q 55_E 2.811 1.00
363_D 367_K 2.751 1.00
320_Y 418_T 2.714 1.00
324_M 416_V 2.674 1.00
377_R 392_E 2.672 1.00
364_I 403_R 2.661 1.00
294_E 330_R 2.506 1.00
98_E 132_R 2.48 1.00
362_I 391_L 2.445 1.00
349_Q 358_I 2.429 1.00
30_G 73_K 2.413 1.00
285_E 318_S 2.412 1.00
205_L 208_E 2.373 1.00
72_H 240_A 2.323 1.00
100_N 103_L 2.262 1.00
43_Q 52_L 2.215 1.00
60_G 63_D 2.198 1.00
211_G 216_P 2.167 1.00
328_I 332_E 2.154 1.00
442_S 448_A 2.131 1.00
371_D 398_G 2.121 1.00
422_M 450_K 2.071 1.00
359_L 363_D 2.048 1.00
396_L 404_V 2.032 1.00
422_M 447_L 2.011 1.00
93_I 210_V 1.987 1.00
27_N 59_S 1.978 1.00
102_E 120_S 1.959 1.00
366_K 372_V 1.952 1.00
364_I 368_E 1.951 1.00
89_I 214_L 1.933 1.00
28_F 211_G 1.921 1.00
198_L 351_S 1.921 1.00
314_L 425_A 1.919 1.00
322_R 326_R 1.901 1.00
101_L 125_P 1.892 1.00
373_L 397_F 1.886 1.00
359_L 378_R 1.878 1.00
69_D 238_R 1.873 1.00
450_K 454_G 1.87 1.00
433_Q 479_Q 1.866 1.00
325_E 329_R 1.855 1.00
231_E 235_T 1.834 1.00
359_L 391_L 1.833 1.00
159_E 498_K 1.828 1.00
96_R 212_D 1.827 1.00
313_A 414_L 1.822 1.00
371_D 397_F 1.82 1.00
235_T 257_Y 1.801 1.00
65_D 232_Y 1.795 1.00
403_R 407_E 1.791 1.00
96_R 213_L 1.785 1.00
275_N 296_F 1.779 1.00
331_V 395_I 1.777 1.00
95_D 99_Q 1.758 1.00
65_D 69_D 1.758 1.00
252_Q 479_Q 1.751 1.00
96_R 99_Q 1.75 1.00
158_H 495_Q 1.719 1.00
328_I 373_L 1.702 1.00
75_K 79_A 1.696 1.00
314_L 428_L 1.696 1.00
103_L 205_L 1.688 1.00
372_V 396_L 1.677 1.00
96_R 209_I 1.676 1.00
158_H 492_E 1.671 1.00
456_Q 478_K 1.667 1.00
320_Y 324_M 1.658 1.00
321_E 418_T 1.653 1.00
32_E 216_P 1.634 1.00
400_N 428_L 1.628 1.00
253_Q 256_Q 1.617 1.00
424_E 427_E 1.616 1.00
207_M 221_V 1.609 1.00
296_F 323_F 1.598 1.00
316_Q 419_F 1.592 1.00
190_C 218_V 1.592 1.00
107_A 205_L 1.591 1.00
423_E 454_G 1.585 1.00
286_D 447_L 1.582 1.00
131_F 182_A 1.569 1.00
405_F 417_T 1.565 1.00
95_D 132_R 1.558 1.00
370_A 396_L 1.547 1.00
322_R 325_E 1.544 1.00
100_N 212_D 1.538 1.00
26_D 35_A 1.534 1.00
426_L 451_M 1.528 1.00
285_E 447_L 1.528 1.00
420_K 424_E 1.522 1.00
102_E 106_T 1.517 1.00
438_A 457_A 1.508 1.00
360_N 403_R 1.502 1.00
330_R 333_S 1.494 1.00
98_E 128_I 1.487 1.00
335_R 343_V 1.487 1.00
91_F 132_R 1.48 1.00
363_D 366_K 1.471 1.00
289_F 326_R 1.47 1.00
65_D 236_S 1.456 1.00
92_K 95_D 1.454 1.00
52_L 55_E 1.432 1.00
45_L 52_L 1.419 1.00
352_H 389_Y 1.415 1.00
315_V 323_F 1.415 1.00
356_E 360_N 1.412 1.00
320_Y 397_F 1.405 0.99
34_V 66_L 1.403 0.99
295_G 441_W 1.401 0.99
85_D 88_A 1.395 0.99
421_T 424_E 1.39 0.99
301_F 331_V 1.39 0.99
106_T 340_L 1.385 0.99
68_L 236_S 1.383 0.99
75_K 190_C 1.383 0.99
293_L 326_R 1.369 0.99
368_E 403_R 1.364 0.99
106_T 110_W 1.353 0.99
296_F 313_A 1.351 0.99
361_Y 409_I 1.35 0.99
326_R 329_R 1.347 0.99
210_V 219_V 1.345 0.99
278_F 419_F 1.344 0.99
137_C 140_A 1.344 0.99
109_T 119_T 1.336 0.99
208_E 212_D 1.335 0.99
104_L 205_L 1.331 0.99
365_G 396_L 1.325 0.99
46_T 49_T 1.324 0.99
355_L 359_L 1.322 0.99
329_R 333_S 1.32 0.99
329_R 332_E 1.315 0.99
80_H 454_G 1.313 0.99
338_N 341_D 1.31 0.99
332_E 374_T 1.307 0.99
82_S 85_D 1.306 0.99
51_Q 387_D 1.305 0.99
64_I 229_I 1.301 0.99
255_M 482_I 1.299 0.99
278_F 447_L 1.297 0.99
166_Q 191_V 1.296 0.99
355_L 391_L 1.292 0.99
81_T 85_D 1.286 0.99
334_I 346_M 1.285 0.99
131_F 178_S 1.283 0.99
116_I 120_S 1.272 0.99
157_F 453_R 1.265 0.99
424_E 428_L 1.259 0.99
63_D 66_L 1.256 0.99
93_I 209_I 1.255 0.99
278_F 451_M 1.25 0.99
177_A 193_L 1.244 0.98
94_A 132_R 1.24 0.98
69_D 73_K 1.239 0.98
241_K 266_T 1.232 0.98
419_F 428_L 1.232 0.98
314_L 419_F 1.227 0.98
207_M 219_V 1.226 0.98
352_H 355_L 1.218 0.98
358_I 411_G 1.207 0.98
100_N 205_L 1.205 0.98
101_L 120_S 1.198 0.98
54_C 201_L 1.193 0.98
41_Y 55_E 1.189 0.98
406_Q 433_Q 1.183 0.98
157_F 500_L 1.181 0.98
91_F 139_R 1.18 0.98
489_M 492_E 1.178 0.98
28_F 33_W 1.172 0.98
104_L 209_I 1.171 0.98
406_Q 431_D 1.17 0.97
158_H 497_T 1.169 0.97
366_K 396_L 1.169 0.97
166_Q 243_A 1.159 0.97
181_M 219_V 1.159 0.97
276_I 425_A 1.155 0.97
92_K 96_R 1.153 0.97
426_L 454_G 1.152 0.97
321_E 325_E 1.15 0.97
144_G 489_M 1.149 0.97
46_T 338_N 1.147 0.97
438_A 460_V 1.147 0.97
316_Q 421_T 1.147 0.97
94_A 98_E 1.146 0.97
231_E 253_Q 1.144 0.97
100_N 209_I 1.135 0.97
327_A 414_L 1.128 0.97
231_E 257_Y 1.125 0.97
323_F 327_A 1.12 0.96
93_I 214_L 1.119 0.96
324_M 328_I 1.116 0.96
93_I 131_F 1.116 0.96
109_T 339_P 1.116 0.96
276_I 451_M 1.112 0.96
50_G 387_D 1.107 0.96
144_G 488_K 1.104 0.96
155_Y 449_Y 1.103 0.96
68_L 238_R 1.103 0.96
81_T 89_I 1.102 0.96
250_V 253_Q 1.099 0.96
400_N 431_D 1.097 0.96
355_L 378_R 1.097 0.96
50_G 389_Y 1.094 0.96
232_Y 236_S 1.093 0.96
316_Q 319_I 1.086 0.96
328_I 374_T 1.085 0.96
253_Q 257_Y 1.085 0.96
197_R 225_A 1.077 0.95
332_E 392_E 1.077 0.95
401_N 406_Q 1.077 0.95
422_M 451_M 1.074 0.95
106_T 116_I 1.073 0.95
324_M 373_L 1.069 0.95
488_K 492_E 1.064 0.95
172_F 306_V 1.062 0.95
255_M 265_V 1.062 0.95
252_Q 262_I 1.06 0.95
319_I 322_R 1.058 0.95
337_G 344_T 1.056 0.95
40_E 58_S 1.051 0.94
452_G 500_L 1.05 0.94
324_M 397_F 1.049 0.94
448_A 462_T 1.047 0.94
335_R 345_Q 1.047 0.94
37_A 66_L 1.045 0.94
163_V 239_I 1.045 0.94
425_A 428_L 1.039 0.94
235_T 260_Q 1.037 0.94
165_G 233_L 1.036 0.94
28_F 207_M 1.034 0.94
423_E 450_K 1.03 0.94
358_I 413_V 1.028 0.94
360_N 364_I 1.028 0.94
370_A 402_M 1.024 0.93
247_S 250_V 1.021 0.93
249_E 253_Q 1.014 0.93
181_M 191_V 1.014 0.93
225_A 228_V 1.009 0.93
30_G 70_A 1.008 0.93
214_L 219_V 1.008 0.93
46_T 110_W 1.008 0.93
274_P 438_A 1.007 0.93
365_G 409_I 1.007 0.93
321_E 324_M 1.007 0.93
275_N 310_P 1.007 0.93
278_F 422_M 1.006 0.93
484_R 496_Q 1.004 0.93
368_E 402_M 1.003 0.93
276_I 429_A 1.002 0.92
278_F 286_D 1.001 0.92
99_Q 212_D 1 0.92
489_M 497_T 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1a4sA40.96881000.123Contact Map0.793
4i8pA20.96291000.126Contact Map0.787
4f3xA40.96091000.13Contact Map0.73
1bxsA40.96481000.131Contact Map0.833
1o04A80.9571000.132Contact Map0.832
3u4jA40.96681000.134Contact Map0.816
3ek1A80.96091000.135Contact Map0.812
4i9bA20.9571000.136Contact Map0.765
3k2wA80.9571000.136Contact Map0.867
3ed6A20.98441000.136Contact Map0.788

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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