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ADH2 - Probable alcohol dehydrogenase
UniProt: P37686 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12293
Length: 383 (380)
Sequences: 4746
Seq/Len: 12.49

ADH2
Paralog alert: 0.76 [within 20: 0.07] - ratio of genomes with paralogs
Cluster includes: ADH2 AROB EUTG FUCO GLDA YBDH YQHD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
351_A 376_V 3.864 1.00
355_T 372_H 3.639 1.00
228_P 333_K 3.628 1.00
290_V 328_R 3.604 1.00
82_K 86_E 3.492 1.00
229_L 236_N 3.385 1.00
347_E 380_R 3.194 1.00
233_D 236_N 3.152 1.00
75_E 155_E 2.829 1.00
265_M 379_Y 2.709 1.00
218_K 221_T 2.627 1.00
49_G 53_K 2.602 1.00
80_G 107_I 2.452 1.00
226_N 242_A 2.438 1.00
350_F 376_V 2.366 1.00
346_K 349_D 2.345 1.00
195_A 223_I 2.34 1.00
376_V 380_R 2.255 1.00
199_A 219_A 2.245 1.00
196_L 220_V 2.245 1.00
49_G 52_Q 2.197 1.00
175_N 244_A 2.184 1.00
17_D 178_S 2.176 1.00
16_A 178_S 2.173 1.00
67_G 79_A 2.171 1.00
339_G 342_D 2.153 1.00
371_T 374_E 2.135 1.00
181_I 237_A 2.115 1.00
101_H 135_A 2.068 1.00
329_E 333_K 2.068 1.00
34_T 91_S 2.055 1.00
353_L 379_Y 2.045 1.00
354_A 376_V 2.042 1.00
21_D 24_N 2.041 1.00
213_D 299_R 2.006 1.00
69_Q 76_N 1.948 1.00
292_N 366_N 1.948 1.00
190_A 279_V 1.927 1.00
377_A 381_A 1.892 1.00
33_R 61_F 1.891 1.00
290_V 381_A 1.89 1.00
188_T 240_R 1.884 1.00
283_V 343_L 1.844 1.00
266_A 280_C 1.83 1.00
92_V 104_A 1.798 1.00
31_F 91_S 1.768 1.00
84_L 131_L 1.767 1.00
79_A 82_K 1.73 1.00
372_H 376_V 1.729 1.00
41_M 45_L 1.677 1.00
287_H 382_A 1.66 1.00
220_V 303_C 1.645 1.00
52_Q 56_E 1.608 1.00
18_S 21_D 1.598 1.00
290_V 321_E 1.583 1.00
229_L 233_D 1.582 1.00
50_D 178_S 1.58 1.00
192_G 227_L 1.574 1.00
354_A 372_H 1.569 1.00
326_A 329_E 1.56 1.00
332_K 338_A 1.559 1.00
185_K 189_A 1.542 1.00
315_N 318_E 1.533 1.00
38_T 41_M 1.505 1.00
23_M 54_A 1.504 1.00
56_E 62_S 1.498 1.00
115_G 119_D 1.474 1.00
224_A 307_M 1.472 1.00
377_A 380_R 1.471 1.00
236_N 239_A 1.471 1.00
304_A 323_C 1.467 1.00
76_N 79_A 1.461 1.00
325_N 329_E 1.454 1.00
53_K 57_E 1.453 1.00
34_T 93_I 1.449 1.00
78_A 116_D 1.444 1.00
238_K 242_A 1.441 1.00
223_I 243_M 1.438 1.00
228_P 232_E 1.437 1.00
229_L 238_K 1.437 1.00
188_T 230_A 1.435 1.00
37_V 107_I 1.432 1.00
180_M 240_R 1.429 1.00
321_E 325_N 1.421 1.00
63_V 87_N 1.42 1.00
180_M 244_A 1.41 1.00
264_A 363_G 1.409 1.00
32_T 90_D 1.396 0.99
77_V 152_I 1.377 0.99
298_A 316_D 1.375 0.99
351_A 372_H 1.372 0.99
16_A 237_A 1.37 0.99
188_T 234_G 1.359 0.99
77_V 103_C 1.355 0.99
154_D 157_R 1.354 0.99
192_G 243_M 1.354 0.99
265_M 284_L 1.347 0.99
26_M 91_S 1.345 0.99
91_S 134_I 1.338 0.99
40_N 44_K 1.333 0.99
341_R 383_M 1.33 0.99
115_G 120_Y 1.327 0.99
84_L 89_C 1.324 0.99
275_L 280_C 1.318 0.99
94_S 133_M 1.316 0.99
265_M 375_I 1.3 0.99
352_V 355_T 1.295 0.99
232_E 333_K 1.292 0.99
63_V 83_L 1.288 0.99
63_V 89_C 1.287 0.99
94_S 104_A 1.283 0.99
374_E 377_A 1.276 0.99
25_M 28_D 1.273 0.99
355_T 359_K 1.273 0.99
43_T 66_D 1.269 0.99
226_N 229_L 1.267 0.99
11_V 25_M 1.261 0.99
37_V 68_T 1.255 0.99
83_L 87_N 1.251 0.99
20_T 50_D 1.249 0.99
217_L 302_D 1.235 0.98
193_M 331_A 1.233 0.98
73_T 76_N 1.222 0.98
69_Q 73_T 1.216 0.98
231_V 335_D 1.208 0.98
33_R 88_N 1.205 0.98
78_A 82_K 1.2 0.98
352_V 356_N 1.199 0.98
183_M 187_L 1.197 0.98
94_S 101_H 1.196 0.98
213_D 216_A 1.189 0.98
17_D 176_D 1.174 0.98
219_A 250_A 1.172 0.98
305_A 319_G 1.166 0.97
108_A 130_Q 1.165 0.97
202_A 253_A 1.163 0.97
186_S 279_V 1.16 0.97
134_I 172_L 1.156 0.97
51_V 95_L 1.155 0.97
287_H 381_A 1.155 0.97
83_L 86_E 1.143 0.97
293_S 320_A 1.135 0.97
289_Q 327_I 1.134 0.97
74_T 78_A 1.133 0.97
185_K 231_V 1.133 0.97
297_A 317_A 1.132 0.97
52_Q 62_S 1.132 0.97
104_A 133_M 1.13 0.97
16_A 181_I 1.125 0.97
12_N 248_F 1.121 0.97
217_L 306_A 1.12 0.96
13_V 25_M 1.106 0.96
294_K 368_I 1.104 0.96
84_L 111_A 1.103 0.96
178_S 181_I 1.102 0.96
140_A 188_T 1.101 0.96
82_K 85_K 1.098 0.96
272_F 352_V 1.094 0.96
16_A 241_E 1.093 0.96
40_N 66_D 1.091 0.96
200_I 220_V 1.091 0.96
81_L 110_V 1.087 0.96
291_F 374_E 1.087 0.96
193_M 336_I 1.083 0.96
177_S 241_E 1.083 0.96
178_S 237_A 1.08 0.95
350_F 380_R 1.078 0.95
303_C 323_C 1.066 0.95
214_A 218_K 1.066 0.95
202_A 216_A 1.062 0.95
254_F 259_L 1.062 0.95
199_A 250_A 1.056 0.95
225_E 242_A 1.056 0.95
217_L 221_T 1.051 0.94
185_K 232_E 1.051 0.94
94_S 135_A 1.047 0.94
262_V 281_N 1.046 0.94
71_N 274_N 1.045 0.94
69_Q 79_A 1.042 0.94
202_A 213_D 1.041 0.94
287_H 290_V 1.038 0.94
226_N 238_K 1.037 0.94
226_N 239_A 1.035 0.94
349_D 352_V 1.028 0.94
351_A 355_T 1.027 0.94
22_A 136_I 1.025 0.93
204_V 289_Q 1.024 0.93
73_T 274_N 1.02 0.93
189_A 231_V 1.019 0.93
230_A 234_G 1.018 0.93
231_V 334_V 1.017 0.93
197_T 285_L 1.016 0.93
92_V 108_A 1.014 0.93
373_E 376_V 1.01 0.93
266_A 270_G 1.01 0.93
53_K 56_E 1.005 0.93
35_L 89_C 1.002 0.92
27_A 58_R 1.001 0.92
234_G 240_R 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3bfjA2011000.091Contact Map0.824
3ox4A411000.093Contact Map0.839
4fr2A111000.107Contact Map0.588
1rrmA20.99481000.108Contact Map0.782
1vljA20.99221000.121Contact Map0.74
1oj7A40.98431000.14Contact Map0.7
3zdrA10.98691000.15Contact Map0.791
1o2dA20.93211000.19Contact Map0.692
3hl0A20.89821000.211Contact Map0.736
3jzdA40.9061000.213Contact Map0.728

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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