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GPMI - 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
UniProt: P37689 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12296
Length: 514 (507)
Sequences: 1114
Seq/Len: 2.20

GPMI
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
201_E 205_D 5.693 1.00
381_E 427_E 4.088 1.00
315_N 504_E 4.032 1.00
356_D 392_Y 3.7 1.00
224_Q 228_A 3.657 1.00
388_K 434_S 3.572 1.00
29_S 411_M 3.521 1.00
380_T 399_Y 3.295 1.00
411_M 415_V 3.16 1.00
200_V 269_E 3.094 1.00
32_T 36_D 3 1.00
34_V 426_E 2.828 1.00
226_A 231_E 2.714 1.00
318_G 330_R 2.604 1.00
136_E 172_K 2.562 1.00
218_T 221_A 2.507 1.00
18_Y 46_L 2.504 1.00
167_K 171_E 2.499 1.00
37_A 41_N 2.457 1.00
52_L 89_K 2.422 1.00
495_S 509_P 2.421 1.00
131_I 260_M 2.41 1.00
202_K 237_K 2.37 1.00
71_L 489_I 2.338 1.00
53_E 485_K 2.32 1.00
321_M 394_T 2.267 1.00
170_E 174_A 2.265 1.00
152_L 236_V 2.259 1.00
104_D 108_N 2.255 1.00
121_A 165_S 2.229 1.00
399_Y 428_V 2.211 1.00
319_E 323_K 2.207 1.00
495_S 501_I 2.194 1.00
390_G 435_V 2.176 1.00
188_Y 366_A 2.175 1.00
39_W 44_H 2.165 1.00
160_R 232_N 2.138 1.00
148_L 173_F 2.131 1.00
132_M 172_K 2.083 0.99
382_K 385_A 2.059 0.99
112_A 145_K 2.053 0.99
48_D 53_E 2.044 0.99
373_E 416_K 2.026 0.99
87_E 308_Y 1.939 0.99
320_W 324_N 1.936 0.99
132_M 168_K 1.926 0.99
105_K 256_A 1.921 0.99
112_A 147_Y 1.919 0.99
103_V 137_L 1.915 0.99
207_L 251_M 1.911 0.99
136_E 140_E 1.905 0.99
163_E 224_Q 1.901 0.99
380_T 427_E 1.9 0.99
29_S 415_V 1.884 0.99
216_A 239_T 1.878 0.99
170_E 219_A 1.867 0.98
170_E 218_T 1.851 0.98
100_T 141_R 1.847 0.98
488_D 507_G 1.82 0.98
116_M 151_F 1.819 0.98
251_M 257_L 1.813 0.98
112_A 252_E 1.803 0.98
152_L 162_A 1.797 0.98
231_E 237_K 1.79 0.98
145_K 180_R 1.733 0.97
251_M 274_F 1.729 0.97
327_T 391_K 1.713 0.97
185_I 206_L 1.711 0.97
134_M 260_M 1.706 0.97
221_A 225_A 1.706 0.97
104_D 141_R 1.7 0.97
172_K 175_A 1.694 0.97
163_E 167_K 1.691 0.97
206_L 240_V 1.689 0.97
432_V 437_G 1.687 0.97
70_N 77_V 1.684 0.97
387_I 431_A 1.676 0.96
102_A 256_A 1.669 0.96
111_K 254_G 1.666 0.96
170_E 220_V 1.657 0.96
253_D 289_N 1.624 0.96
501_I 509_P 1.62 0.95
35_M 425_V 1.615 0.95
135_V 173_F 1.608 0.95
470_L 489_I 1.606 0.95
102_A 106_A 1.565 0.94
88_I 133_A 1.55 0.94
432_V 439_L 1.543 0.94
190_A 203_A 1.541 0.94
86_V 90_D 1.538 0.94
121_A 128_E 1.536 0.93
24_D 452_R 1.533 0.93
440_L 496_L 1.516 0.93
96_N 307_A 1.51 0.93
394_T 493_M 1.505 0.93
31_K 419_E 1.499 0.92
7_P 437_G 1.499 0.92
9_V 432_V 1.495 0.92
429_A 439_L 1.495 0.92
431_A 435_V 1.485 0.92
279_F 282_F 1.484 0.92
34_V 38_L 1.483 0.92
377_A 423_H 1.472 0.91
272_R 276_N 1.47 0.91
501_I 508_K 1.47 0.91
16_Y 27_I 1.452 0.91
78_Y 86_V 1.452 0.91
384_V 388_K 1.452 0.91
19_R 28_F 1.445 0.90
388_K 431_A 1.439 0.90
11_V 439_L 1.434 0.90
94_F 140_E 1.423 0.90
143_A 146_I 1.418 0.89
420_A 424_C 1.417 0.89
317_F 394_T 1.406 0.89
226_A 229_R 1.403 0.89
97_P 101_G 1.401 0.89
441_I 473_V 1.396 0.88
356_D 391_K 1.389 0.88
217_D 221_A 1.375 0.87
377_A 424_C 1.373 0.87
332_S 400_P 1.373 0.87
331_I 397_C 1.372 0.87
88_I 93_F 1.362 0.87
297_E 310_P 1.354 0.86
360_I 382_K 1.353 0.86
13_L 35_M 1.353 0.86
326_K 393_D 1.348 0.86
358_I 382_K 1.343 0.86
382_K 386_A 1.342 0.86
315_N 323_K 1.34 0.85
402_G 418_V 1.339 0.85
412_E 415_V 1.331 0.85
22_Q 28_F 1.328 0.85
147_Y 182_A 1.319 0.84
495_S 511_F 1.314 0.84
33_P 36_D 1.31 0.84
128_E 132_M 1.308 0.83
166_L 223_L 1.304 0.83
348_V 352_F 1.304 0.83
331_I 383_L 1.299 0.83
201_E 211_Q 1.297 0.83
431_A 434_S 1.296 0.83
183_S 240_V 1.293 0.82
115_I 131_I 1.293 0.82
442_T 489_I 1.292 0.82
185_I 238_A 1.291 0.82
71_L 344_F 1.286 0.82
209_L 285_K 1.284 0.82
321_M 326_K 1.282 0.82
115_I 260_M 1.282 0.82
207_L 270_I 1.281 0.82
34_V 37_A 1.279 0.82
383_L 397_C 1.279 0.82
414_A 451_M 1.278 0.81
387_I 395_I 1.273 0.81
293_V 307_A 1.272 0.81
163_E 220_V 1.272 0.81
384_V 431_A 1.268 0.81
317_F 493_M 1.263 0.80
166_L 181_V 1.259 0.80
222_G 239_T 1.259 0.80
85_D 129_D 1.258 0.80
195_N 272_R 1.257 0.80
160_R 230_D 1.255 0.80
366_A 370_L 1.253 0.80
313_L 316_T 1.25 0.79
371_Q 377_A 1.238 0.79
33_P 419_E 1.237 0.78
106_A 113_V 1.231 0.78
386_A 392_Y 1.231 0.78
414_A 448_A 1.222 0.77
410_V 413_A 1.22 0.77
106_A 256_A 1.217 0.77
170_E 181_V 1.213 0.77
11_V 425_V 1.206 0.76
384_V 427_E 1.203 0.76
135_V 146_I 1.201 0.76
83_R 296_T 1.194 0.75
384_V 387_I 1.192 0.75
164_S 167_K 1.188 0.74
8_M 394_T 1.187 0.74
35_M 39_W 1.185 0.74
70_N 73_A 1.183 0.74
380_T 384_V 1.174 0.73
87_E 93_F 1.173 0.73
205_D 211_Q 1.171 0.73
377_A 420_A 1.167 0.73
320_W 499_M 1.167 0.73
331_I 379_L 1.166 0.72
100_T 104_D 1.166 0.72
453_D 458_Q 1.163 0.72
113_V 138_A 1.162 0.72
329_L 358_I 1.162 0.72
259_F 267_A 1.16 0.72
106_A 111_K 1.151 0.71
387_I 435_V 1.149 0.71
452_R 457_G 1.147 0.71
202_K 238_A 1.139 0.70
205_D 209_L 1.139 0.70
80_D 83_R 1.138 0.70
181_V 219_A 1.136 0.70
19_R 22_Q 1.129 0.69
420_A 423_H 1.126 0.69
360_I 386_A 1.121 0.68
426_E 430_K 1.12 0.68
69_V 448_A 1.119 0.68
86_V 92_A 1.114 0.67
148_L 169_F 1.113 0.67
158_P 161_S 1.113 0.67
226_A 237_K 1.11 0.67
16_Y 418_V 1.101 0.66
13_L 425_V 1.099 0.66
275_V 302_I 1.091 0.65
103_V 138_A 1.088 0.65
16_Y 32_T 1.087 0.65
418_V 448_A 1.087 0.65
345_N 348_V 1.085 0.64
272_R 302_I 1.085 0.64
101_G 305_A 1.079 0.64
353_K 500_E 1.074 0.63
35_M 471_I 1.073 0.63
189_Y 237_K 1.072 0.63
32_T 419_E 1.07 0.63
95_A 100_T 1.07 0.63
273_A 282_F 1.068 0.63
184_I 223_L 1.068 0.63
216_A 222_G 1.066 0.62
73_A 77_V 1.064 0.62
45_T 483_G 1.06 0.62
275_V 304_T 1.045 0.60
70_N 485_K 1.045 0.60
259_F 270_I 1.045 0.60
115_I 134_M 1.044 0.60
83_R 311_A 1.043 0.60
183_S 206_L 1.043 0.60
146_I 178_K 1.041 0.60
377_A 381_E 1.04 0.60
136_E 175_A 1.037 0.59
453_D 456_T 1.035 0.59
317_F 344_F 1.035 0.59
351_S 356_D 1.032 0.59
27_I 448_A 1.031 0.59
386_A 389_S 1.03 0.59
229_R 237_K 1.023 0.58
485_K 508_K 1.023 0.58
98_V 101_G 1.022 0.58
415_V 419_E 1.019 0.57
377_A 427_E 1.019 0.57
163_E 223_L 1.016 0.57
27_I 35_M 1.015 0.57
107_K 141_R 1.013 0.57
171_E 175_A 1.01 0.56
102_A 293_V 1.009 0.56
322_A 353_K 1.001 0.55
259_F 292_F 1.001 0.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1o98A10.98831000.193Contact Map0.767
4my4A10.98641000.215Contact Map0.764
3igzB10.99031000.217Contact Map0.639
2zktA20.70231000.828Contact Map0.461
3kd8A20.70231000.83Contact Map0.366
1zedA10.733599.90.887Contact Map0.399
2i09A20.719899.90.897Contact Map0.486
3tg0A40.663499.90.902Contact Map0.504
3ot9A30.708299.90.904Contact Map0.487
3nkqA10.599.80.916Contact Map0.498

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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