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YECC - Uncharacterized amino-acid ABC transporter ATP-binding protein YecC
UniProt: P37774 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12347
Length: 250 (241)
Sequences: 71269
Seq/Len: 295.72

YECC
Paralog alert: 0.94 [within 20: 0.86] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
33_A 211_A 3.328 1.00
30_E 213_R 3.138 1.00
5_E 25_E 3.126 1.00
137_K 140_S 3.039 1.00
7_K 59_T 2.961 1.00
8_N 21_G 2.93 1.00
59_T 66_T 2.924 1.00
86_H 164_E 2.761 1.00
32_V 215_I 2.701 1.00
17_T 20_H 2.698 1.00
130_A 135_A 2.646 1.00
5_E 61_T 2.607 1.00
20_H 221_R 2.535 1.00
27_K 30_E 2.501 1.00
213_R 225_Q 2.41 1.00
10_V 21_G 2.326 1.00
6_V 9_L 2.307 1.00
124_R 162_R 2.238 1.00
226_G 230_A 2.192 1.00
11_K 48_S 2.188 1.00
12_K 17_T 2.152 1.00
63_G 164_E 2.122 1.00
10_V 17_T 2.083 1.00
129_L 138_E 2.021 1.00
227_A 230_A 2.008 1.00
126_R 138_E 2.001 1.00
102_V 145_L 1.996 1.00
10_V 57_A 1.984 1.00
215_I 222_I 1.935 1.00
103_L 139_T 1.932 1.00
7_K 61_T 1.89 1.00
28_P 164_E 1.837 1.00
103_L 138_E 1.82 1.00
8_N 23_D 1.769 1.00
103_L 126_R 1.766 1.00
30_E 212_D 1.763 1.00
162_R 195_R 1.746 1.00
13_F 18_V 1.74 1.00
215_I 225_Q 1.714 1.00
131_K 189_Q 1.708 1.00
189_Q 193_E 1.666 1.00
11_K 56_E 1.659 1.00
103_L 125_A 1.636 1.00
131_K 193_E 1.634 1.00
127_E 131_K 1.599 1.00
122_T 126_R 1.559 1.00
117_P 120_E 1.554 1.00
124_R 127_E 1.541 1.00
92_Q 147_G 1.51 1.00
103_L 122_T 1.487 1.00
191_A 212_D 1.472 1.00
140_S 144_R 1.472 1.00
103_L 107_I 1.451 1.00
46_L 200_V 1.449 1.00
226_G 231_L 1.438 1.00
12_K 56_E 1.437 1.00
201_T 207_A 1.437 1.00
11_K 53_E 1.429 1.00
19_L 48_S 1.427 1.00
61_T 66_T 1.409 1.00
107_I 125_A 1.4 0.99
24_L 215_I 1.382 0.99
7_K 25_E 1.382 0.99
6_V 49_I 1.381 0.99
107_I 121_A 1.376 0.99
26_V 32_V 1.376 0.99
48_S 55_P 1.35 0.99
123_A 127_E 1.348 0.99
135_A 138_E 1.335 0.99
106_I 160_A 1.306 0.99
10_V 20_H 1.304 0.99
105_N 157_R 1.295 0.99
46_L 167_L 1.293 0.99
63_G 86_H 1.286 0.99
6_V 24_L 1.275 0.99
3_A 63_G 1.26 0.99
168_F 187_I 1.24 0.98
32_V 225_Q 1.237 0.98
126_R 130_A 1.235 0.98
7_K 23_D 1.197 0.98
101_T 104_E 1.197 0.98
66_T 69_T 1.196 0.98
9_L 55_P 1.195 0.98
128_L 160_A 1.195 0.98
31_V 191_A 1.188 0.98
124_R 128_L 1.184 0.98
126_R 135_A 1.182 0.98
49_I 198_V 1.165 0.97
45_L 217_M 1.162 0.97
13_F 44_T 1.162 0.97
137_K 149_Q 1.153 0.97
102_V 153_V 1.141 0.97
107_I 122_T 1.14 0.97
237_Q 240_T 1.132 0.97
191_A 197_M 1.125 0.97
27_K 213_R 1.119 0.96
6_V 45_L 1.119 0.96
188_R 191_A 1.114 0.96
11_K 44_T 1.108 0.96
180_V 206_F 1.105 0.96
31_V 197_M 1.103 0.96
186_T 189_Q 1.09 0.96
145_L 153_V 1.09 0.96
106_I 129_L 1.088 0.96
90_V 155_I 1.083 0.96
132_V 156_A 1.079 0.95
47_R 53_E 1.079 0.95
48_S 60_I 1.077 0.95
223_V 237_Q 1.075 0.95
50_N 89_F 1.074 0.95
22_I 45_L 1.071 0.95
88_G 163_P 1.066 0.95
12_K 18_V 1.063 0.95
168_F 197_M 1.062 0.95
164_E 195_R 1.059 0.95
184_L 206_F 1.056 0.95
100_R 104_E 1.054 0.95
32_V 213_R 1.052 0.95
28_P 63_G 1.05 0.94
127_E 130_A 1.03 0.94
190_L 195_R 1.021 0.93
129_L 134_L 1.017 0.93
120_E 123_A 1.017 0.93
104_E 107_I 1.014 0.93
8_N 57_A 1 0.92
166_I 197_M 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2it1A20.956100-0.048Contact Map0.871
3tuiC40.976100-0.047Contact Map0.886
1v43A10.956100-0.046Contact Map0.82
2yyzA10.956100-0.045Contact Map0.816
1g29120.976100-0.043Contact Map0.898
1oxxK10.976100-0.042Contact Map0.808
3rlfA20.956100-0.04Contact Map0.848
1z47A20.956100-0.035Contact Map0.843
3fvqA20.972100-0.032Contact Map0.787
2oljA20.968100-0.019Contact Map0.893

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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