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CHAC - Cation transport protein ChaC
UniProt: P39163 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12403
Length: 231 (219)
Sequences: 280
Seq/Len: 1.28

CHAC
Paralog alert: 0.07 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
78_F 189_L 2.846 1.00
189_L 213_V 2.71 1.00
65_E 110_R 2.591 1.00
124_W 135_P 2.115 0.98
94_R 192_L 2.043 0.98
104_T 192_L 2.003 0.97
175_I 189_L 1.984 0.97
124_W 128_M 1.945 0.97
82_L 95_M 1.933 0.96
85_G 182_L 1.786 0.94
80_L 132_C 1.736 0.92
78_F 175_I 1.725 0.92
197_I 207_N 1.701 0.91
32_A 36_A 1.669 0.90
175_I 185_N 1.66 0.90
65_E 146_R 1.614 0.88
8_M 18_A 1.486 0.82
99_K 157_P 1.451 0.80
80_L 155_M 1.438 0.79
166_T 192_L 1.435 0.79
94_R 166_T 1.418 0.78
99_K 162_Y 1.414 0.77
128_M 135_P 1.412 0.77
142_L 146_R 1.372 0.74
94_R 104_T 1.348 0.73
107_V 206_L 1.317 0.70
186_A 190_F 1.314 0.70
46_P 113_E 1.305 0.69
75_H 102_G 1.303 0.69
51_G 84_A 1.272 0.66
163_E 166_T 1.263 0.65
175_I 209_L 1.255 0.65
46_P 89_A 1.24 0.63
67_C 146_R 1.24 0.63
104_T 166_T 1.229 0.62
75_H 101_G 1.225 0.62
48_W 108_A 1.225 0.62
13_K 17_G 1.225 0.62
27_A 125_K 1.222 0.62
7_L 11_D 1.219 0.61
16_F 19_I 1.217 0.61
70_T 105_T 1.216 0.61
80_L 97_A 1.216 0.61
173_P 177_A 1.216 0.61
48_W 110_R 1.212 0.61
12_C 16_F 1.199 0.59
191_S 195_E 1.197 0.59
175_I 214_K 1.189 0.58
7_L 12_C 1.179 0.57
64_T 112_P 1.168 0.56
137_W 153_F 1.165 0.56
70_T 187_Q 1.163 0.56
174_L 178_A 1.16 0.56
101_G 137_W 1.159 0.55
124_W 153_F 1.155 0.55
31_A 36_A 1.151 0.55
6_F 9_N 1.151 0.55
109_Y 117_E 1.14 0.54
172_A 176_A 1.138 0.53
58_N 77_A 1.135 0.53
12_C 19_I 1.133 0.53
111_L 201_M 1.133 0.53
96_L 159_H 1.129 0.53
172_A 175_I 1.12 0.52
66_S 105_T 1.119 0.52
10_A 20_E 1.116 0.51
208_D 211_V 1.115 0.51
9_N 15_A 1.111 0.51
48_W 65_E 1.111 0.51
124_W 133_Y 1.108 0.50
8_M 19_I 1.106 0.50
7_L 19_I 1.104 0.50
126_R 133_Y 1.104 0.50
35_A 39_A 1.102 0.50
30_R 77_A 1.098 0.49
101_G 110_R 1.096 0.49
70_T 107_V 1.095 0.49
91_Q 177_A 1.095 0.49
26_S 30_R 1.09 0.49
6_F 19_I 1.085 0.48
98_L 120_L 1.084 0.48
10_A 13_K 1.081 0.48
31_A 121_T 1.08 0.48
142_L 145_G 1.079 0.48
208_D 212_S 1.078 0.47
68_T 107_V 1.076 0.47
26_S 29_Q 1.071 0.47
4_R 7_L 1.064 0.46
79_C 156_D 1.057 0.45
202_Q 212_S 1.056 0.45
6_F 12_C 1.055 0.45
100_E 109_Y 1.055 0.45
94_R 163_E 1.053 0.45
68_T 105_T 1.051 0.45
9_N 12_C 1.045 0.44
193_E 206_L 1.044 0.44
56_M 197_I 1.044 0.44
65_E 148_V 1.041 0.44
10_A 16_F 1.038 0.44
15_A 24_L 1.037 0.43
84_A 130_T 1.035 0.43
79_C 99_K 1.032 0.43
128_M 153_F 1.03 0.43
58_N 96_L 1.029 0.43
78_F 213_V 1.026 0.42
6_F 17_G 1.026 0.42
134_L 154_I 1.022 0.42
96_L 140_L 1.018 0.42
176_A 186_A 1.016 0.41
11_D 20_E 1.014 0.41
47_V 110_R 1.013 0.41
108_A 142_L 1.011 0.41
105_T 194_Q 1.01 0.41
63_F 66_S 1.008 0.41
6_F 18_A 1.007 0.41
97_A 105_T 1.006 0.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3cryA20.77921000.611Contact Map0.241
2qikA10.80091000.622Contact Map0.254
3judA10.597499.80.754Contact Map0.188
2jqvA10.666799.80.77Contact Map0.249
2g0qA10.701399.60.807Contact Map0.288
1xhsA10.502297.80.899Contact Map0.414
1v30A10.506597.50.905Contact Map0.373
1vkbA10.610496.80.916Contact Map0.292
4issA20.7749640.953Contact Map0.195
4gysA20.722962.30.953Contact Map0.25

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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