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CAIE - Carnitine operon protein CaiE
UniProt: P39206 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12608
Length: 196 (173)
Sequences: 1764
Seq/Len: 10.20

CAIE
Paralog alert: 0.39 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: CAIE MAA PAAY THGA WBBJ WCAF YRDA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
55_G 77_N 3.362 1.00
64_M 72_T 3.244 1.00
14_H 33_A 2.684 1.00
127_G 133_L 2.635 1.00
92_G 111_E 2.537 1.00
33_A 54_A 2.465 1.00
94_D 112_E 2.414 1.00
54_A 76_E 2.369 1.00
75_G 93_R 2.318 1.00
34_G 55_G 2.301 1.00
116_A 134_M 2.258 1.00
108_V 126_R 2.258 1.00
70_T 106_G 2.15 1.00
9_L 28_D 2.145 1.00
112_E 130_R 2.126 1.00
39_P 166_C 2.113 1.00
77_N 94_D 2.09 1.00
86_L 89_C 2.024 1.00
30_I 51_I 1.958 1.00
63_I 83_G 1.884 1.00
93_R 111_E 1.87 1.00
35_V 76_E 1.835 1.00
25_L 29_V 1.824 1.00
32_G 54_A 1.802 1.00
76_E 93_R 1.796 1.00
20_H 39_P 1.772 1.00
12_V 30_I 1.762 1.00
55_G 160_Q 1.755 1.00
103_I 107_A 1.741 1.00
113_S 131_Q 1.696 1.00
111_E 129_K 1.693 1.00
41_A 62_C 1.692 1.00
110_G 126_R 1.676 1.00
142_R 148_E 1.659 1.00
5_A 8_G 1.621 1.00
22_S 40_L 1.616 1.00
16_T 34_G 1.6 1.00
122_K 125_F 1.573 1.00
25_L 31_V 1.568 1.00
130_R 149_L 1.553 1.00
133_L 140_A 1.543 1.00
92_G 108_V 1.538 1.00
110_G 129_K 1.487 1.00
62_C 84_A 1.463 1.00
13_V 17_A 1.458 1.00
145_S 148_E 1.446 1.00
7_E 165_R 1.444 1.00
5_A 10_I 1.417 1.00
28_D 49_R 1.336 0.99
61_G 83_G 1.314 0.99
105_D 123_A 1.297 0.99
115_V 127_G 1.292 0.99
113_S 129_K 1.289 0.99
121_V 138_A 1.287 0.99
31_V 37_I 1.267 0.99
37_I 43_L 1.243 0.98
16_T 33_A 1.242 0.98
58_I 80_I 1.222 0.98
131_Q 140_A 1.211 0.98
90_L 108_V 1.208 0.98
102_V 118_M 1.207 0.98
110_G 128_E 1.193 0.98
40_L 61_G 1.156 0.97
79_H 155_N 1.141 0.97
122_K 138_A 1.127 0.97
128_E 133_L 1.122 0.97
131_Q 143_N 1.121 0.97
95_A 113_S 1.121 0.97
115_V 133_L 1.115 0.96
85_I 100_N 1.111 0.96
115_V 138_A 1.102 0.96
140_A 143_N 1.096 0.96
15_P 33_A 1.075 0.95
83_G 100_N 1.072 0.95
133_L 138_A 1.067 0.95
112_E 149_L 1.064 0.95
119_S 138_A 1.062 0.95
30_I 49_R 1.057 0.95
32_G 76_E 1.04 0.94
84_A 101_S 1.034 0.94
29_V 45_G 1.034 0.94
31_V 35_V 1.027 0.94
85_I 99_M 1.023 0.93
128_E 131_Q 1.023 0.93
77_N 160_Q 1.012 0.93
134_M 141_V 1.009 0.93
14_H 17_A 1.007 0.93
22_S 39_P 1.007 0.93
128_E 140_A 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1v3wA10.88271000.471Contact Map0.803
1xhdA10.87241000.479Contact Map0.807
3r3rA10.89291000.48Contact Map0.848
3ixcA10.8521000.491Contact Map0.819
3r1wA30.88271000.495Contact Map0.871
4mfgA40.84691000.503Contact Map0.846
3c8vA40.9491000.507Contact Map0.599
3hsqA30.97451000.535Contact Map0.694
3tv0A20.88271000.543Contact Map0.753
1j2zA10.97451000.545Contact Map0.645

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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