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BDCA - Cyclic-di-GMP-binding biofilm dispersal mediator protein
UniProt: P39333 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12528
Length: 237 (234)
Sequences: 55017
Seq/Len: 235.12

BDCA
Paralog alert: 0.89 [within 20: 0.50] - ratio of genomes with paralogs
Cluster includes: BDCA ENTA FABG FABI FOLM HCAB HDHA IDNO KDUD SRLD UCPA YBBO YCIK YDFG YGCW YGFF YGHA YOHF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
100_D 108_H 3.33 1.00
100_D 104_K 3.029 1.00
151_S 155_G 2.896 1.00
129_I 157_A 2.718 1.00
62_D 65_A 2.403 1.00
9_V 78_I 2.401 1.00
20_A 24_R 2.389 1.00
126_R 170_T 2.358 1.00
114_S 160_L 2.267 1.00
131_G 154_Q 2.255 1.00
41_K 45_K 2.252 1.00
180_D 205_Q 2.218 1.00
175_Q 228_M 2.208 1.00
25_R 211_G 2.131 1.00
104_K 108_H 2.115 1.00
81_V 129_I 2.102 1.00
118_A 164_F 2.033 1.00
78_I 217_A 2.017 1.00
32_N 54_T 2.002 1.00
8_T 32_N 1.979 1.00
36_T 58_T 1.929 1.00
25_R 214_A 1.91 1.00
25_R 29_D 1.905 1.00
18_I 179_I 1.854 1.00
211_G 220_E 1.851 1.00
227_A 230_T 1.85 1.00
63_R 96_A 1.81 1.00
110_P 153_L 1.799 1.00
24_R 50_E 1.781 1.00
106_N 149_S 1.778 1.00
20_A 47_L 1.76 1.00
22_I 213_V 1.728 1.00
157_A 173_V 1.718 1.00
20_A 50_E 1.706 1.00
212_M 229_H 1.7 1.00
67_I 116_E 1.691 1.00
14_G 35_F 1.689 1.00
107_I 152_A 1.667 1.00
34_R 73_S 1.649 1.00
44_A 55_A 1.644 1.00
103_F 107_I 1.605 1.00
26_F 217_A 1.594 1.00
25_R 28_T 1.589 1.00
8_T 75_A 1.575 1.00
29_D 214_A 1.569 1.00
80_V 130_I 1.564 1.00
126_R 172_N 1.554 1.00
40_S 43_A 1.552 1.00
31_A 78_I 1.512 1.00
96_A 112_H 1.492 1.00
16_R 182_D 1.491 1.00
15_S 37_Y 1.487 1.00
95_N 98_D 1.478 1.00
204_G 223_F 1.449 1.00
79_L 113_A 1.447 1.00
9_V 26_F 1.433 1.00
45_K 49_Q 1.422 1.00
48_A 55_A 1.417 1.00
6_G 31_A 1.415 1.00
67_I 71_R 1.4 0.99
81_V 114_S 1.385 0.99
41_K 57_F 1.365 0.99
21_A 24_R 1.357 0.99
131_G 173_V 1.34 0.99
9_V 31_A 1.335 0.99
157_A 171_I 1.315 0.99
114_S 127_I 1.304 0.99
108_H 112_H 1.303 0.99
8_T 34_R 1.297 0.99
21_A 207_E 1.288 0.99
26_F 31_A 1.283 0.99
63_R 112_H 1.278 0.99
179_I 204_G 1.277 0.99
122_P 167_R 1.273 0.99
23_V 35_F 1.269 0.99
212_M 231_I 1.258 0.99
4_F 31_A 1.254 0.99
174_V 213_V 1.242 0.98
76_L 117_A 1.24 0.98
58_T 65_A 1.22 0.98
87_V 101_R 1.2 0.98
160_L 171_I 1.193 0.98
24_R 28_T 1.191 0.98
103_F 108_H 1.186 0.98
79_L 117_A 1.182 0.98
16_R 43_A 1.179 0.98
25_R 210_A 1.179 0.98
32_N 53_A 1.148 0.97
96_A 108_H 1.147 0.97
65_A 68_D 1.146 0.97
45_K 48_A 1.141 0.97
85_I 105_I 1.14 0.97
111_Y 156_M 1.134 0.97
82_N 130_I 1.113 0.96
97_D 101_R 1.11 0.96
61_A 101_R 1.108 0.96
146_Y 150_K 1.099 0.96
89_G 98_D 1.093 0.96
8_T 73_S 1.089 0.96
130_I 213_V 1.089 0.96
90_E 93_E 1.089 0.96
114_S 156_M 1.087 0.96
173_V 228_M 1.076 0.95
110_P 129_I 1.073 0.95
34_R 56_V 1.064 0.95
154_Q 228_M 1.059 0.95
46_R 50_E 1.056 0.95
21_A 206_P 1.051 0.94
7_K 77_D 1.047 0.94
70_V 117_A 1.044 0.94
26_F 214_A 1.041 0.94
27_V 51_T 1.04 0.94
99_I 108_H 1.031 0.94
22_I 210_A 1.027 0.94
25_R 207_E 1.027 0.94
85_I 101_R 1.026 0.94
215_W 224_V 1.024 0.93
66_V 113_A 1.022 0.93
60_S 109_A 1.011 0.93
22_I 80_V 1.01 0.93
18_I 22_I 1.009 0.93
46_R 49_Q 1.006 0.93
16_R 20_A 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4fgsA40.99161000.045Contact Map0.866
3op4A20.99161000.045Contact Map0.798
4i5fA80.99161000.047Contact Map0.899
4esoA40.98731000.049Contact Map0.814
1vl8A20.99161000.05Contact Map0.814
3grpA40.99161000.05Contact Map0.869
2c07A10.99161000.052Contact Map0.771
2a4kA20.98731000.052Contact Map0.685
4j2hA10.99161000.053Contact Map0.754
3v2gA111000.054Contact Map0.741

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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