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YJJN - Putative L-galactonate oxidoreductase
UniProt: P39400 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12590
Length: 340 (336)
Sequences: 22707
Seq/Len: 67.58

YJJN
Paralog alert: 0.83 [within 20: 0.37] - ratio of genomes with paralogs
Cluster includes: ACUI ADHP CURA FRMA GATD IDND QOR1 RSPB TDH YAHK YBDR YCJQ YDJJ YDJL YGGP YJGB YJJN YPHC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
318_T 321_E 3.472 1.00
35_K 139_P 3.262 1.00
33_K 69_V 3.153 1.00
35_K 67_E 2.95 1.00
30_A 131_I 2.931 1.00
31_L 69_V 2.875 1.00
10_Q 18_K 2.854 1.00
183_K 209_P 2.834 1.00
138_D 141_A 2.752 1.00
82_Q 133_P 2.695 1.00
314_Y 325_R 2.584 1.00
165_Q 188_Q 2.573 1.00
79_K 82_Q 2.509 1.00
221_Q 224_A 2.489 1.00
199_R 204_T 2.458 1.00
28_N 74_N 2.445 1.00
33_K 67_E 2.433 1.00
27_D 73_K 2.42 1.00
200_E 205_R 2.405 1.00
140_Q 313_R 2.402 1.00
33_K 123_Y 2.35 1.00
8_I 18_K 2.301 1.00
297_R 301_E 2.293 1.00
315_P 318_T 2.264 1.00
166_V 182_A 2.253 1.00
10_Q 16_V 2.237 1.00
77_D 128_V 2.226 1.00
27_D 74_N 2.187 1.00
200_E 204_T 2.186 1.00
22_I 123_Y 2.176 1.00
136_G 300_A 2.164 1.00
83_Q 139_P 2.135 1.00
312_H 325_R 2.131 1.00
161_A 164_E 2.122 1.00
167_L 231_A 2.109 1.00
196_P 200_E 2.104 1.00
64_I 119_G 2.093 1.00
179_A 208_L 2.076 1.00
24_I 70_G 2.072 1.00
164_E 256_T 2.049 1.00
65_C 139_P 1.994 1.00
251_I 257_V 1.982 1.00
321_E 324_E 1.972 1.00
26_G 29_E 1.969 1.00
324_E 328_I 1.947 1.00
31_L 125_S 1.944 1.00
167_L 192_A 1.937 1.00
196_P 212_D 1.918 1.00
314_Y 322_T 1.916 1.00
5_N 19_Q 1.876 1.00
83_Q 135_D 1.871 1.00
69_V 123_Y 1.858 1.00
193_D 199_R 1.854 1.00
232_Q 252_R 1.752 1.00
256_T 280_T 1.744 1.00
72_G 75_I 1.738 1.00
70_G 80_N 1.731 1.00
202_V 205_R 1.724 1.00
48_G 327_V 1.703 1.00
251_I 255_G 1.701 1.00
158_A 233_K 1.69 1.00
64_I 86_V 1.682 1.00
71_L 80_N 1.675 1.00
7_L 319_L 1.668 1.00
321_E 325_R 1.662 1.00
216_E 221_Q 1.661 1.00
25_P 125_S 1.639 1.00
29_E 127_P 1.636 1.00
169_V 247_T 1.63 1.00
78_L 133_P 1.622 1.00
251_I 279_T 1.615 1.00
212_D 215_A 1.612 1.00
184_A 303_K 1.611 1.00
5_N 122_E 1.609 1.00
217_D 220_A 1.606 1.00
190_V 231_A 1.606 1.00
95_C 98_C 1.589 1.00
67_E 83_Q 1.577 1.00
148_F 177_G 1.57 1.00
234_V 247_T 1.549 1.00
313_R 339_T 1.547 1.00
179_A 191_V 1.541 1.00
68_I 78_L 1.539 1.00
256_T 282_M 1.531 1.00
5_N 317_A 1.523 1.00
120_F 323_Y 1.523 1.00
28_N 127_P 1.513 1.00
171_A 191_V 1.5 1.00
34_I 64_I 1.494 1.00
29_E 125_S 1.489 1.00
325_R 330_N 1.483 1.00
78_L 82_Q 1.476 1.00
196_P 215_A 1.475 1.00
31_L 123_Y 1.458 1.00
31_L 70_G 1.445 1.00
92_C 95_C 1.441 1.00
6_V 20_R 1.429 1.00
30_A 78_L 1.428 1.00
36_S 140_Q 1.427 1.00
188_Q 210_L 1.42 1.00
7_L 17_W 1.407 0.99
25_P 29_E 1.391 0.99
297_R 300_A 1.383 0.99
67_E 139_P 1.375 0.99
165_Q 190_V 1.374 0.99
11_Q 14_E 1.368 0.99
25_P 31_L 1.365 0.99
156_R 294_K 1.354 0.99
320_A 324_E 1.354 0.99
194_T 213_P 1.352 0.99
234_V 251_I 1.35 0.99
188_Q 209_P 1.349 0.99
220_A 224_A 1.343 0.99
35_K 83_Q 1.321 0.99
47_W 323_Y 1.296 0.99
178_A 235_I 1.294 0.99
36_S 339_T 1.292 0.99
78_L 131_I 1.282 0.99
32_I 66_G 1.272 0.99
311_T 325_R 1.261 0.99
169_V 192_A 1.258 0.99
36_S 139_P 1.228 0.98
39_I 322_T 1.223 0.98
160_I 187_A 1.223 0.98
95_C 106_C 1.221 0.98
205_R 308_M 1.217 0.98
141_A 307_D 1.216 0.98
298_L 303_K 1.216 0.98
98_C 106_C 1.215 0.98
126_V 131_I 1.214 0.98
191_V 208_L 1.196 0.98
165_Q 232_Q 1.194 0.98
28_N 128_V 1.179 0.98
40_C 62_H 1.173 0.98
22_I 31_L 1.162 0.97
92_C 98_C 1.161 0.97
221_Q 225_Q 1.159 0.97
168_V 178_A 1.158 0.97
305_T 308_M 1.151 0.97
196_P 199_R 1.147 0.97
184_A 298_L 1.128 0.97
7_L 316_F 1.126 0.97
141_A 305_T 1.125 0.97
34_I 124_L 1.117 0.96
40_C 63_E 1.112 0.96
17_W 317_A 1.102 0.96
158_A 258_V 1.101 0.96
38_G 63_E 1.098 0.96
140_Q 339_T 1.094 0.96
156_R 291_D 1.082 0.96
294_K 297_R 1.071 0.95
194_T 214_S 1.07 0.95
236_D 239_G 1.068 0.95
71_L 75_I 1.068 0.95
324_E 327_V 1.039 0.94
164_E 232_Q 1.035 0.94
35_K 65_C 1.033 0.94
199_R 212_D 1.032 0.94
137_I 142_A 1.03 0.94
151_S 181_I 1.025 0.93
180_A 305_T 1.019 0.93
293_A 297_R 1.015 0.93
168_V 182_A 1.01 0.93
32_I 84_V 1.007 0.93
33_K 122_E 1.004 0.93
28_N 73_K 1 0.92
69_V 80_N 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4ej6A10.98241000.064Contact Map0.799
4ilkA20.98821000.066Contact Map0.807
4a2cA20.97941000.071Contact Map0.743
1h2bA20.97941000.077Contact Map0.812
3ukoA20.98531000.087Contact Map0.746
2dq4A20.97351000.089Contact Map0.809
1f8fA10.97941000.091Contact Map0.818
3m6iA20.98821000.091Contact Map0.836
1kolA20.98531000.092Contact Map0.766
1e3iA20.98241000.092Contact Map0.829

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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