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BGLJ - Transcriptional activator protein BglJ
UniProt: P39404 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12594
Length: 225 (202)
Sequences: 28784
Seq/Len: 142.50

BGLJ
Paralog alert: 0.94 [within 20: 0.56] - ratio of genomes with paralogs
Cluster includes: ARCA BAER BASR BGLJ CPXR CREB CSGD CUSR DCUR DPIA EVGA FIMZ KDPE NARL NARP OMPR PHOB PHOP QSEB RCSB RSTA TORR UHPA UVRY YEDW YGEK YHJB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
21_S 40_T 3.598 1.00
21_S 42_T 2.912 1.00
25_E 40_T 2.693 1.00
45_E 67_R 2.593 1.00
156_T 159_E 2.464 1.00
43_S 67_R 2.415 1.00
14_I 47_F 2.403 1.00
71_R 79_E 2.368 1.00
25_E 29_R 2.304 1.00
98_E 119_T 2.287 1.00
182_K 185_R 2.211 1.00
44_Q 71_R 2.208 1.00
157_E 194_K 2.198 1.00
170_M 185_R 2.188 1.00
43_S 46_S 2.107 1.00
102_I 122_I 2.095 1.00
52_S 83_K 2.063 1.00
48_Q 79_E 2.041 1.00
27_L 120_L 2.039 1.00
10_N 35_P 1.945 1.00
72_E 75_S 1.878 1.00
42_T 46_S 1.86 1.00
41_Y 50_A 1.843 1.00
162_R 166_R 1.831 1.00
37_K 56_F 1.786 1.00
187_H 190_N 1.765 1.00
58_A 127_L 1.742 1.00
90_L 130_S 1.709 1.00
77_L 89_R 1.708 1.00
28_F 127_L 1.698 1.00
91_V 105_L 1.671 1.00
61_F 76_C 1.652 1.00
163_F 176_Q 1.624 1.00
107_P 128_F 1.615 1.00
64_S 95_D 1.597 1.00
163_F 173_I 1.588 1.00
63_F 91_V 1.562 1.00
111_D 133_G 1.561 1.00
61_F 77_L 1.561 1.00
169_S 172_Q 1.559 1.00
79_E 82_I 1.55 1.00
12_A 41_Y 1.546 1.00
31_F 124_H 1.521 1.00
77_L 91_V 1.515 1.00
168_Y 176_Q 1.49 1.00
91_V 110_L 1.485 1.00
10_N 37_K 1.485 1.00
205_E 213_M 1.483 1.00
59_V 87_T 1.45 1.00
71_R 75_S 1.447 1.00
81_A 111_D 1.435 1.00
44_Q 76_C 1.434 1.00
14_I 65_A 1.422 1.00
67_R 71_R 1.404 0.99
95_D 101_L 1.391 0.99
15_E 21_S 1.385 0.99
48_Q 76_C 1.374 0.99
39_H 56_F 1.368 0.99
74_L 108_S 1.347 0.99
75_S 78_T 1.322 0.99
79_E 83_K 1.313 0.99
50_A 54_I 1.307 0.99
45_E 71_R 1.303 0.99
49_D 53_R 1.29 0.99
50_A 53_R 1.257 0.99
63_F 74_L 1.253 0.99
112_G 126_E 1.252 0.99
163_F 168_Y 1.245 0.98
154_S 194_K 1.21 0.98
34_N 128_F 1.197 0.98
18_V 42_T 1.196 0.98
45_E 49_D 1.193 0.98
33_G 128_F 1.191 0.98
48_Q 71_R 1.185 0.98
51_M 80_L 1.183 0.98
188_K 192_M 1.174 0.98
97_I 101_L 1.16 0.97
31_F 128_F 1.143 0.97
186_A 189_F 1.136 0.97
78_T 104_S 1.133 0.97
171_T 181_I 1.133 0.97
58_A 131_L 1.13 0.97
171_T 175_E 1.125 0.97
16_K 62_S 1.115 0.96
130_S 133_G 1.11 0.96
46_S 49_D 1.105 0.96
11_V 34_N 1.105 0.96
41_Y 47_F 1.105 0.96
183_T 187_H 1.102 0.96
100_R 104_S 1.094 0.96
39_H 54_I 1.081 0.95
24_I 92_I 1.079 0.95
74_L 104_S 1.074 0.95
168_Y 172_Q 1.073 0.95
37_K 50_A 1.061 0.95
46_S 50_A 1.047 0.94
14_I 59_V 1.042 0.94
47_F 51_M 1.041 0.94
197_V 206_A 1.038 0.94
12_A 56_F 1.035 0.94
129_L 134_V 1.032 0.94
98_E 103_G 1.029 0.94
12_A 47_F 1.023 0.93
24_I 123_F 1.012 0.93
103_G 121_E 1.012 0.93
65_A 76_C 1.009 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3c3wA20.94671000.181Contact Map0.628
4gvpA40.89781000.193Contact Map0.805
4hyeA20.921000.2Contact Map0.798
1a04A20.91111000.201Contact Map0.684
3kloA40.94221000.211Contact Map0.463
1ys7A20.92891000.218Contact Map0.779
1yioA10.921000.239Contact Map0.688
4b09A120.95111000.247Contact Map0.673
1p2fA10.90221000.252Contact Map0.756
1kgsA10.90671000.257Contact Map0.716

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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