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RSMC - Ribosomal RNA small subunit methyltransferase C
UniProt: P39406 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12596
Length: 343 (333)
Sequences: 559
Seq/Len: 1.68

RSMC
Paralog alert: 0.69 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: RLMG RSMC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
214_F 266_I 3.156 1.00
201_L 262_F 3.043 1.00
321_E 333_R 2.686 1.00
200_V 214_F 2.442 1.00
211_S 225_L 2.366 1.00
298_E 333_R 2.31 1.00
283_Q 312_V 2.3 1.00
85_P 91_A 2.273 1.00
225_L 236_S 2.161 0.99
224_T 262_F 2.096 0.99
234_E 237_R 2.06 0.99
267_S 301_I 1.958 0.98
205_C 227_D 1.91 0.98
322_V 325_Q 1.887 0.98
199_K 294_N 1.873 0.97
22_R 78_D 1.737 0.95
183_V 328_R 1.642 0.93
300_R 323_I 1.632 0.93
47_Q 229_S 1.623 0.93
200_V 264_M 1.6 0.92
214_F 221_I 1.59 0.92
114_N 117_G 1.586 0.92
224_T 250_F 1.582 0.91
212_V 245_V 1.576 0.91
271_F 307_L 1.57 0.91
271_F 304_N 1.559 0.91
310_P 330_K 1.546 0.90
200_V 221_I 1.533 0.90
43_R 266_I 1.529 0.90
263_D 294_N 1.514 0.89
250_F 258_V 1.488 0.88
304_N 307_L 1.483 0.88
199_K 222_R 1.477 0.87
185_S 210_L 1.459 0.86
212_V 239_T 1.449 0.86
98_L 106_T 1.441 0.85
49_F 53_Q 1.436 0.85
300_R 333_R 1.415 0.84
187_L 326_T 1.413 0.84
286_I 308_P 1.41 0.84
199_K 224_T 1.408 0.84
171_T 178_R 1.397 0.83
317_F 330_K 1.358 0.80
177_S 180_G 1.357 0.80
237_R 248_E 1.355 0.80
190_S 326_T 1.355 0.80
167_L 212_V 1.352 0.80
305_A 308_P 1.348 0.80
58_Q 62_N 1.343 0.79
187_L 191_T 1.341 0.79
120_S 187_L 1.33 0.79
233_V 237_R 1.322 0.78
22_R 77_C 1.321 0.78
139_R 203_V 1.318 0.78
175_V 324_A 1.31 0.77
240_L 249_V 1.306 0.77
191_T 324_A 1.306 0.77
280_D 284_T 1.305 0.77
114_N 119_R 1.3 0.76
204_G 226_C 1.3 0.76
102_L 106_T 1.297 0.76
192_L 214_F 1.293 0.76
303_A 307_L 1.286 0.75
211_S 223_L 1.284 0.75
241_A 246_E 1.277 0.74
286_I 313_L 1.27 0.74
233_V 322_V 1.264 0.73
164_V 181_L 1.258 0.73
118_V 121_A 1.251 0.72
188_L 266_I 1.249 0.72
47_Q 50_H 1.235 0.71
23_I 79_T 1.228 0.70
210_L 302_V 1.227 0.70
65_F 327_G 1.221 0.70
56_S 233_V 1.218 0.69
96_M 158_F 1.215 0.69
174_G 267_S 1.209 0.69
303_A 309_Y 1.189 0.67
49_F 257_E 1.179 0.66
134_V 142_L 1.178 0.66
114_N 122_E 1.169 0.65
115_R 185_S 1.166 0.64
304_N 309_Y 1.166 0.64
187_L 212_V 1.165 0.64
211_S 280_D 1.162 0.64
113_E 140_C 1.162 0.64
55_L 185_S 1.161 0.64
39_T 42_S 1.158 0.64
39_T 331_V 1.155 0.63
282_A 286_I 1.152 0.63
289_A 299_L 1.144 0.62
57_R 105_G 1.139 0.62
232_A 265_I 1.135 0.61
303_A 308_P 1.135 0.61
161_E 220_K 1.125 0.60
84_W 90_E 1.124 0.60
87_N 174_G 1.115 0.59
294_N 323_I 1.115 0.59
77_C 276_Q 1.114 0.59
169_V 210_L 1.114 0.59
129_A 281_A 1.112 0.59
256_S 331_V 1.111 0.59
185_S 254_V 1.111 0.59
171_T 235_A 1.107 0.59
189_L 209_V 1.103 0.58
271_F 303_A 1.097 0.57
213_A 217_H 1.086 0.56
105_G 296_G 1.085 0.56
144_F 331_V 1.081 0.56
308_P 311_D 1.081 0.56
91_A 115_R 1.078 0.56
83_Y 111_V 1.07 0.55
113_E 117_G 1.07 0.55
92_Q 317_F 1.064 0.54
12_L 33_L 1.062 0.54
83_Y 90_E 1.058 0.53
78_D 103_P 1.049 0.52
210_L 225_L 1.045 0.52
90_E 173_P 1.045 0.52
141_G 203_V 1.044 0.52
276_Q 282_A 1.044 0.52
110_V 121_A 1.041 0.52
165_D 233_V 1.033 0.51
125_L 291_R 1.032 0.51
187_L 190_S 1.032 0.51
313_L 334_A 1.031 0.51
279_L 303_A 1.03 0.50
143_Y 176_F 1.029 0.50
108_I 294_N 1.028 0.50
25_F 37_L 1.027 0.50
171_T 177_S 1.027 0.50
276_Q 285_L 1.026 0.50
217_H 237_R 1.024 0.50
230_A 329_F 1.021 0.49
11_L 42_S 1.018 0.49
314_D 320_H 1.017 0.49
51_H 171_T 1.016 0.49
170_K 238_A 1.014 0.49
154_D 157_K 1.012 0.48
173_P 178_R 1.012 0.48
203_V 254_V 1.011 0.48
163_S 168_T 1.008 0.48
195_H 222_R 1.007 0.48
239_T 243_N 1.004 0.48
11_L 63_A 1.004 0.48
237_R 241_A 1.003 0.48
139_R 207_A 1.002 0.47
308_P 314_D 1.001 0.47
12_L 16_D 1.001 0.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2pjdA10.99711000.374Contact Map0.489
4dcmA10.98831000.398Contact Map0.546
3dmgA10.9651000.474Contact Map0.516
1dusA10.545299.90.757Contact Map0.653
4dzrA10.495699.80.798Contact Map0.515
2ozvA20.524899.80.802Contact Map0.657
3evzA10.583199.80.803Contact Map0.592
3lpmA20.556999.80.803Contact Map0.599
2b3tA10.714399.80.805Contact Map0.59
4mtlA20.626899.80.811Contact Map0.598

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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