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ARFB - Peptidyl-tRNA hydrolase YaeJ
UniProt: P40711 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12354
Length: 140 (136)
Sequences: 845
Seq/Len: 6.21

ARFB
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
111_T 114_S 4.836 1.00
29_H 33_T 3.953 1.00
76_E 86_A 3.622 1.00
113_A 117_R 3.003 1.00
125_K 128_V 2.809 1.00
116_E 120_A 2.764 1.00
19_A 37_I 2.609 1.00
17_I 88_L 2.459 1.00
92_V 96_K 2.233 1.00
112_R 116_E 2.203 1.00
120_A 124_Q 2.194 1.00
40_R 71_V 2.124 1.00
119_L 123_A 2.101 1.00
74_A 87_A 1.95 1.00
97_E 100_T 1.825 1.00
42_D 45_A 1.802 1.00
77_Y 86_A 1.771 1.00
20_I 34_S 1.748 1.00
29_H 79_S 1.747 1.00
49_P 52_Y 1.683 1.00
123_A 126_S 1.643 1.00
14_E 46_S 1.63 1.00
41_F 46_S 1.604 1.00
35_T 80_Q 1.531 0.99
110_P 114_S 1.493 0.99
35_T 79_S 1.475 0.99
43_I 64_I 1.433 0.99
89_A 96_K 1.399 0.98
128_V 131_M 1.367 0.98
116_E 119_L 1.333 0.98
42_D 69_V 1.319 0.97
43_I 56_L 1.315 0.97
22_A 34_S 1.27 0.96
22_A 35_T 1.258 0.96
29_H 32_K 1.245 0.96
38_H 73_K 1.236 0.96
5_S 8_V 1.227 0.95
129_K 132_R 1.21 0.95
74_A 86_A 1.206 0.95
8_V 52_Y 1.204 0.95
50_E 54_E 1.19 0.94
109_R 112_R 1.183 0.94
20_I 36_A 1.18 0.94
57_L 61_H 1.173 0.94
20_I 38_H 1.135 0.92
19_A 34_S 1.135 0.92
23_Q 75_Q 1.134 0.92
79_S 86_A 1.117 0.92
105_R 108_T 1.097 0.91
17_I 84_R 1.095 0.90
17_I 37_I 1.088 0.90
41_F 53_K 1.083 0.90
44_R 57_L 1.071 0.89
72_I 87_A 1.066 0.89
37_I 80_Q 1.058 0.88
65_S 71_V 1.056 0.88
43_I 57_L 1.042 0.87
3_V 6_R 1.031 0.87
18_T 38_H 1.023 0.86
74_A 77_Y 1.007 0.85
82_L 85_E 1.005 0.85
70_I 94_M 1.004 0.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4dh9Y111000.117Contact Map0.382
2jvaA10.77141000.304Contact Map0.531
1j26A10.74291000.336Contact Map0.377
1gqeA10.814399.90.516Contact Map0.374
2rsmA10.585799.90.536Contact Map0.551
2b3tB10.821499.80.565Contact Map0.467
1rq0A30.821499.80.57Contact Map0.524
2ihr110.814399.80.575Contact Map0.487
3d5aX10.821499.80.577Contact Map0.628
1zbtA10.821499.80.577Contact Map0.746

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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