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AZOR - FMN-dependent NADH-azoreductase
UniProt: P41407 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12695
Length: 201 (199)
Sequences: 3270
Seq/Len: 16.43

AZOR
Paralog alert: 0.64 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: AZOR KEFF KEFG MDAB NQOR YCAK
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
39_T 83_E 3.961 1.00
3_K 37_E 3.772 1.00
39_T 86_A 2.9 1.00
42_D 45_A 2.719 1.00
41_R 83_E 2.69 1.00
82_A 86_A 2.545 1.00
50_V 103_T 2.417 1.00
135_A 161_L 2.304 1.00
24_Y 27_E 2.245 1.00
24_Y 192_K 2.228 1.00
106_K 110_D 2.179 1.00
120_R 127_E 2.108 1.00
25_F 138_I 2.096 1.00
26_V 30_R 2.02 1.00
23_D 27_E 2.006 1.00
6_V 26_V 1.963 1.00
3_K 86_A 1.931 1.00
85_K 117_V 1.904 1.00
50_V 107_N 1.886 1.00
39_T 87_H 1.849 1.00
4_V 36_D 1.823 1.00
54_E 57_G 1.763 1.00
78_D 82_A 1.73 1.00
135_A 166_I 1.671 1.00
82_A 85_K 1.635 1.00
101_I 156_Y 1.627 1.00
46_N 79_E 1.625 1.00
18_S 140_S 1.621 1.00
77_S 81_I 1.614 1.00
53_G 56_V 1.602 1.00
28_Q 31_E 1.597 1.00
27_E 31_E 1.584 1.00
23_D 40_V 1.56 1.00
134_K 167_T 1.556 1.00
103_T 107_N 1.55 1.00
89_V 136_I 1.53 1.00
90_I 135_A 1.507 1.00
181_P 185_A 1.502 1.00
87_H 90_I 1.479 1.00
27_E 30_R 1.452 1.00
94_A 102_S 1.415 1.00
84_L 90_I 1.409 1.00
28_Q 32_K 1.405 0.99
8_K 22_S 1.401 0.99
107_N 111_L 1.388 0.99
193_A 197_S 1.387 0.99
22_S 93_A 1.383 0.99
193_A 196_D 1.378 0.99
189_S 193_A 1.372 0.99
8_K 40_V 1.361 0.99
90_I 166_I 1.355 0.99
6_V 22_S 1.354 0.99
189_S 192_K 1.339 0.99
81_I 117_V 1.334 0.99
28_Q 196_D 1.32 0.99
109_F 160_F 1.312 0.99
4_V 89_V 1.308 0.99
137_V 171_F 1.29 0.99
99_F 163_F 1.278 0.99
18_S 93_A 1.261 0.99
92_I 105_L 1.26 0.99
28_Q 195_I 1.259 0.99
89_V 134_K 1.256 0.99
25_F 29_W 1.254 0.99
185_A 189_S 1.243 0.98
187_A 190_D 1.243 0.98
3_K 39_T 1.238 0.98
27_E 192_K 1.221 0.98
180_G 183_M 1.22 0.98
51_L 54_E 1.206 0.98
8_K 19_N 1.2 0.98
9_S 104_Q 1.192 0.98
68_P 71_Q 1.181 0.98
80_L 108_Y 1.163 0.97
53_G 57_G 1.162 0.97
79_E 83_E 1.158 0.97
81_I 118_T 1.149 0.97
88_D 133_K 1.145 0.97
186_K 190_D 1.131 0.97
76_L 79_E 1.13 0.97
192_K 196_D 1.124 0.97
30_R 37_E 1.1 0.96
138_I 172_V 1.094 0.96
141_R 175_E 1.085 0.96
113_A 164_I 1.079 0.95
19_N 42_D 1.073 0.95
29_W 36_D 1.071 0.95
78_D 114_R 1.057 0.95
67_T 70_Q 1.052 0.95
41_R 108_Y 1.048 0.94
11_I 97_Y 1.042 0.94
82_A 117_V 1.04 0.94
151_D 155_P 1.039 0.94
9_S 105_L 1.036 0.94
96_M 153_V 1.033 0.94
24_Y 188_Q 1.024 0.93
25_F 91_V 1.024 0.93
54_E 69_R 1.021 0.93
6_V 40_V 1.016 0.93
41_R 46_N 1.013 0.93
28_Q 192_K 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1t5bA20.9951000.239Contact Map0.756
2hpvA40.98511000.262Contact Map0.742
4c0xA10.98511000.265Contact Map0.68
3r6wA20.9951000.268Contact Map0.673
3p0rA10.991000.272Contact Map0.69
1d4aA40.97011000.283Contact Map0.744
3u7iA40.98011000.285Contact Map0.749
3lcmA40.93531000.3Contact Map0.841
4gi5A20.97011000.301Contact Map0.755
4fglA40.95021000.321Contact Map0.75

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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