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PAT - Putrescine aminotransferase
UniProt: P42588 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12718
Length: 459 (408)
Sequences: 9541
Seq/Len: 23.38

PAT
Paralog alert: 0.89 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: ARGD ASTC BIOA GABT GSA PAT PUUE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
108_Q 112_A 4.785 1.00
411_Q 447_K 4.439 1.00
258_R 262_D 4.365 1.00
75_T 83_E 3.934 1.00
365_M 439_E 3.797 1.00
354_N 357_A 3.495 1.00
132_T 348_N 3.411 1.00
69_Q 77_V 3.357 1.00
215_I 256_A 3.299 1.00
105_S 109_N 3.118 1.00
282_K 288_H 3.078 1.00
365_M 435_I 2.982 1.00
102_V 352_E 2.922 1.00
376_E 446_R 2.919 1.00
434_T 437_Q 2.9 1.00
358_Q 362_K 2.795 1.00
102_V 345_A 2.614 1.00
361_Q 435_I 2.609 1.00
345_A 348_N 2.555 1.00
256_A 259_K 2.482 1.00
369_G 442_I 2.448 1.00
259_K 263_E 2.426 1.00
132_T 351_L 2.403 1.00
87_C 441_V 2.362 1.00
407_E 410_R 2.342 1.00
102_V 349_V 2.325 1.00
411_Q 451_A 2.282 1.00
100_N 349_V 2.274 1.00
364_D 368_D 2.258 1.00
75_T 437_Q 2.229 1.00
236_I 269_I 2.223 1.00
413_V 444_A 2.089 1.00
407_E 451_A 2.035 1.00
77_V 83_E 2.017 1.00
219_R 263_E 1.994 1.00
377_Y 446_R 1.989 1.00
124_P 128_M 1.982 1.00
367_L 371_R 1.951 1.00
369_G 439_E 1.947 1.00
440_L 444_A 1.938 1.00
407_E 411_Q 1.925 1.00
131_K 135_A 1.919 1.00
143_Y 316_E 1.91 1.00
132_T 344_L 1.906 1.00
107_V 342_A 1.906 1.00
129_L 343_A 1.905 1.00
104_V 108_Q 1.893 1.00
369_G 443_K 1.893 1.00
237_L 257_V 1.89 1.00
71_G 101_P 1.845 1.00
369_G 372_Q 1.839 1.00
82_Q 412_R 1.834 1.00
211_P 217_A 1.827 1.00
78_D 82_Q 1.825 1.00
147_C 310_G 1.817 1.00
176_T 253_Y 1.808 1.00
349_V 353_Q 1.803 1.00
235_V 261_C 1.789 1.00
107_V 111_L 1.747 1.00
130_A 146_F 1.72 1.00
218_M 257_V 1.685 1.00
75_T 440_L 1.678 1.00
298_L 311_A 1.676 1.00
83_E 440_L 1.676 1.00
316_E 320_S 1.668 1.00
142_K 316_E 1.665 1.00
164_Y 318_V 1.637 1.00
252_G 255_T 1.636 1.00
219_R 223_N 1.635 1.00
154_V 297_C 1.635 1.00
377_Y 450_A 1.633 1.00
282_K 360_E 1.627 1.00
367_L 386_G 1.62 1.00
362_K 438_C 1.608 1.00
358_Q 361_Q 1.576 1.00
128_M 344_L 1.564 1.00
132_T 135_A 1.558 1.00
109_N 113_K 1.534 1.00
357_A 361_Q 1.531 1.00
362_K 365_M 1.531 1.00
105_S 108_Q 1.527 1.00
157_A 297_C 1.513 1.00
303_G 309_I 1.506 1.00
298_L 313_I 1.499 1.00
270_L 286_C 1.493 1.00
216_E 219_R 1.492 1.00
161_A 269_I 1.476 1.00
101_P 105_S 1.469 1.00
407_E 448_A 1.468 1.00
219_R 256_A 1.46 1.00
302_L 309_I 1.454 1.00
69_Q 113_K 1.451 1.00
78_D 84_F 1.442 1.00
282_K 287_E 1.438 1.00
362_K 435_I 1.43 1.00
408_M 415_V 1.423 1.00
106_A 345_A 1.423 1.00
137_T 313_I 1.42 1.00
345_A 349_V 1.418 1.00
213_G 250_P 1.417 1.00
258_R 268_M 1.413 1.00
258_R 261_C 1.409 1.00
74_N 437_Q 1.409 1.00
373_L 442_I 1.404 0.99
156_A 312_T 1.401 0.99
237_L 254_L 1.398 0.99
211_P 214_N 1.392 0.99
382_Q 396_V 1.392 0.99
174_I 232_V 1.391 0.99
177_S 211_P 1.387 0.99
100_N 353_Q 1.386 0.99
433_L 438_C 1.385 0.99
74_N 432_T 1.378 0.99
295_I 314_A 1.373 0.99
446_R 450_A 1.37 0.99
367_L 391_M 1.368 0.99
158_L 173_F 1.367 0.99
136_L 351_L 1.366 0.99
235_V 257_V 1.364 0.99
252_G 289_E 1.364 0.99
270_L 291_V 1.363 0.99
144_S 313_I 1.361 0.99
411_Q 448_A 1.354 0.99
99_R 104_V 1.353 0.99
134_A 144_S 1.351 0.99
128_M 348_N 1.346 0.99
71_G 99_R 1.336 0.99
309_I 340_C 1.334 0.99
107_V 338_L 1.33 0.99
71_G 83_E 1.325 0.99
435_I 439_E 1.324 0.99
255_T 259_K 1.319 0.99
257_V 268_M 1.312 0.99
75_T 85_I 1.308 0.99
154_V 236_I 1.304 0.99
365_M 369_G 1.299 0.99
344_L 348_N 1.296 0.99
143_Y 320_S 1.288 0.99
108_Q 111_L 1.278 0.99
289_E 387_K 1.277 0.99
190_A 207_F 1.272 0.99
135_A 351_L 1.271 0.99
109_N 112_A 1.271 0.99
371_R 374_A 1.27 0.99
369_G 446_R 1.267 0.99
267_L 318_V 1.265 0.99
96_V 349_V 1.264 0.99
348_N 352_E 1.262 0.99
292_Q 315_T 1.259 0.99
286_C 296_L 1.25 0.99
222_L 266_A 1.246 0.98
283_M 287_E 1.242 0.98
190_A 236_I 1.237 0.98
309_I 343_A 1.237 0.98
210_V 221_A 1.234 0.98
169_G 231_D 1.219 0.98
175_A 209_H 1.218 0.98
443_K 447_K 1.208 0.98
164_Y 321_V 1.188 0.98
302_L 311_A 1.186 0.98
259_K 262_D 1.185 0.98
437_Q 440_L 1.18 0.98
368_D 372_Q 1.177 0.98
411_Q 444_A 1.176 0.98
307_M 339_A 1.167 0.97
278_G 356_P 1.167 0.97
167_P 170_K 1.167 0.97
288_H 387_K 1.156 0.97
173_F 234_A 1.147 0.97
104_V 112_A 1.146 0.97
104_V 111_L 1.142 0.97
151_T 187_A 1.14 0.97
350_L 356_P 1.139 0.97
295_I 312_T 1.131 0.97
408_M 413_V 1.123 0.97
439_E 443_K 1.111 0.96
240_I 387_K 1.11 0.96
147_C 312_T 1.105 0.96
255_T 290_N 1.103 0.96
350_L 355_L 1.103 0.96
103_V 342_A 1.101 0.96
170_K 265_G 1.1 0.96
440_L 443_K 1.1 0.96
146_F 340_C 1.099 0.96
172_T 231_D 1.098 0.96
74_N 85_I 1.089 0.96
356_P 359_A 1.087 0.96
373_L 446_R 1.082 0.96
360_E 364_D 1.074 0.95
408_M 448_A 1.067 0.95
281_G 287_E 1.067 0.95
153_S 297_C 1.052 0.95
158_L 190_A 1.048 0.94
413_V 441_V 1.044 0.94
136_L 283_M 1.039 0.94
408_M 444_A 1.036 0.94
189_S 204_L 1.032 0.94
216_E 220_T 1.031 0.94
304_G 346_T 1.029 0.94
96_V 346_T 1.028 0.94
371_R 375_R 1.023 0.93
260_L 264_F 1.023 0.93
403_N 407_E 1.018 0.93
167_P 265_G 1.012 0.93
254_L 289_E 1.01 0.93
129_L 344_L 1.009 0.93
277_M 350_L 1.006 0.93
284_F 298_L 1.006 0.93
219_R 264_F 1.002 0.92
71_G 77_V 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4a0gA40.97391000.395Contact Map0.577
3tfuA20.94341000.449Contact Map0.72
2epjA10.89981000.454Contact Map0.703
3hmuA20.92161000.47Contact Map0.816
4e3qA40.93251000.471Contact Map0.781
4ffcA40.92591000.471Contact Map0.66
4atqA120.9151000.474Contact Map0.722
3oksA40.91291000.475Contact Map0.739
4ao9A20.92591000.475Contact Map0.626
2ykyA30.92161000.476Contact Map0.642

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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