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ALX - Inner membrane protein alx
UniProt: P42601 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12731
Length: 321 (316)
Sequences: 788
Seq/Len: 2.49

ALX
Paralog alert: 0.17 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
53_L 80_L 3.782 1.00
188_D 194_V 3.765 1.00
45_S 87_K 3.587 1.00
56_N 80_L 3.281 1.00
195_R 200_L 3.011 1.00
34_H 40_Q 2.611 1.00
193_F 202_A 2.574 1.00
193_F 206_M 2.557 1.00
268_G 304_T 2.548 1.00
106_V 187_I 2.542 1.00
125_L 217_V 2.374 1.00
43_A 47_V 2.299 1.00
127_T 131_F 2.272 1.00
282_I 285_F 2.266 1.00
271_V 300_I 2.227 1.00
136_L 143_I 2.185 1.00
177_L 181_L 2.135 1.00
181_L 202_A 2.07 1.00
155_G 274_V 2.034 0.99
56_N 76_A 2.032 0.99
82_G 227_I 2.016 0.99
292_V 296_V 1.949 0.99
106_V 208_V 1.946 0.99
184_T 188_D 1.883 0.99
176_W 180_H 1.853 0.99
85_I 230_V 1.784 0.98
113_R 190_E 1.768 0.98
35_A 109_A 1.768 0.98
58_A 62_Y 1.761 0.98
121_G 213_E 1.755 0.98
74_P 78_A 1.74 0.98
264_M 311_V 1.726 0.98
23_I 27_L 1.672 0.97
176_W 182_R 1.659 0.97
82_G 237_V 1.644 0.97
50_T 54_L 1.637 0.97
90_A 251_M 1.592 0.96
76_A 80_L 1.592 0.96
91_V 301_L 1.581 0.96
75_Q 233_D 1.579 0.96
56_N 79_F 1.573 0.96
38_M 257_G 1.573 0.96
121_G 125_L 1.558 0.95
57_A 217_V 1.554 0.95
283_V 287_H 1.528 0.95
39_K 43_A 1.497 0.94
272_I 300_I 1.489 0.94
182_R 199_L 1.488 0.94
41_A 44_W 1.474 0.93
81_T 230_V 1.464 0.93
202_A 206_M 1.462 0.93
33_A 190_E 1.455 0.93
296_V 299_G 1.437 0.92
283_V 286_Y 1.425 0.91
123_I 242_L 1.401 0.91
272_I 302_V 1.387 0.90
114_V 212_V 1.363 0.89
45_S 246_L 1.349 0.88
188_D 196_K 1.341 0.88
141_D 145_Y 1.34 0.88
172_P 175_R 1.339 0.88
57_A 61_W 1.326 0.87
152_L 156_V 1.322 0.87
87_K 246_L 1.312 0.86
142_W 149_A 1.3 0.86
264_M 307_I 1.29 0.85
80_L 84_L 1.279 0.84
49_V 87_K 1.266 0.83
77_L 81_T 1.263 0.83
183_M 201_Y 1.259 0.83
176_W 179_G 1.247 0.82
196_K 201_Y 1.245 0.82
184_T 201_Y 1.24 0.82
46_L 50_T 1.24 0.82
52_S 251_M 1.239 0.82
167_G 170_D 1.238 0.82
59_F 236_I 1.236 0.81
82_G 231_T 1.235 0.81
57_A 60_W 1.234 0.81
94_V 97_W 1.23 0.81
91_V 94_V 1.219 0.80
63_L 233_D 1.219 0.80
114_V 120_L 1.211 0.80
134_S 228_F 1.206 0.79
85_I 137_I 1.201 0.79
272_I 303_M 1.199 0.79
59_F 76_A 1.198 0.79
227_I 230_V 1.195 0.78
144_L 276_I 1.178 0.77
184_T 194_V 1.176 0.77
173_L 210_I 1.175 0.77
228_F 231_T 1.168 0.76
128_I 132_T 1.167 0.76
9_L 58_A 1.165 0.76
44_W 48_W 1.165 0.76
8_L 12_G 1.152 0.75
54_L 58_A 1.152 0.75
48_W 119_V 1.152 0.75
14_A 238_L 1.15 0.74
8_L 11_G 1.144 0.74
230_V 267_Y 1.143 0.74
112_R 116_V 1.142 0.74
52_S 79_F 1.141 0.74
144_L 155_G 1.139 0.73
282_I 287_H 1.137 0.73
296_V 300_I 1.136 0.73
80_L 83_Y 1.134 0.73
205_L 209_L 1.125 0.72
291_A 295_G 1.122 0.72
64_V 72_A 1.119 0.72
282_I 286_Y 1.106 0.70
54_L 57_A 1.098 0.70
142_W 145_Y 1.096 0.69
23_I 48_W 1.092 0.69
272_I 301_L 1.09 0.69
289_P 292_V 1.088 0.69
56_N 85_I 1.086 0.68
275_F 296_V 1.082 0.68
117_Y 121_G 1.079 0.68
38_M 45_S 1.07 0.67
157_K 160_L 1.069 0.67
136_L 140_F 1.067 0.66
192_F 213_E 1.066 0.66
233_D 236_I 1.059 0.65
41_A 208_V 1.053 0.65
14_A 19_I 1.052 0.65
53_L 79_F 1.051 0.65
156_V 160_L 1.048 0.64
213_E 245_I 1.042 0.64
218_I 221_V 1.041 0.64
38_M 88_S 1.038 0.63
208_V 215_S 1.038 0.63
224_I 227_I 1.032 0.63
120_L 206_M 1.031 0.62
12_G 16_V 1.03 0.62
302_V 306_I 1.03 0.62
235_F 284_D 1.028 0.62
171_K 174_V 1.027 0.62
19_I 23_I 1.027 0.62
177_L 207_L 1.025 0.62
182_R 201_Y 1.023 0.62
42_A 46_L 1.023 0.62
278_I 288_I 1.02 0.61
90_A 284_D 1.017 0.61
25_L 116_V 1.015 0.61
169_G 185_D 1.011 0.60
124_V 128_I 1.006 0.60
311_V 315_H 1.006 0.60
87_K 250_A 1.004 0.59
177_L 202_A 1.004 0.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results:
PDB Chains Cov P(%) HHΔ   Acc
2m67A10.2118240.975Contact Map0.217
2kncA10.165130.984Contact Map0.263
2xutA30.51092.80.984Contact Map0.149
3pjzA20.19312.60.984Contact Map0.042
2i32E20.14642.20.985Contact Map0
2l8sA10.12462.10.985Contact Map0.09
4kppA20.18382.10.985Contact Map0.069
2rddB10.099720.985Contact Map0.214
4g0dW40.074820.985Contact Map0.21
1fftB20.193120.985Contact Map0.288

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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